孙艳梅，副教授，博导，三秦学者。课题组聚焦典型功能微生物资源的高值化开发与作用机制研究，重点围绕益生菌、噬菌体及富硒微生物等关键类群，系统开展其在健康促进、农业生产与生态调控等领域中的生物学功能解析。通过整合多组学技术、分子生物学与生物信息学等手段，深入揭示功能微生物的代谢调控网络及其与宿主的互作机制，旨在推动其向精准干预和可持续利用方向的应用转化。

主要研究方包括：（1）乳酸菌资源开发与应用；（2）噬菌体资源开发与应用机制；（3）富硒微生物与植物互作机制。主持国家、省部级等纵向科研项目9项，横向项目5项，获授权专利3项，发表SCI学术论文60余篇。

  课题组每年招收博士研究生1-2名、硕士研究生2-3名

  诚邀具有微生物学、生物信息学、分子生物学以及计算生物学等背景的学生加入。联系邮箱：sunyanmei（at）nwu.edu.cn(at换@）

优秀硕士毕业生可推荐至清华大学、浙江大学、中国农业大学、西北工业大学、中科院北京微生物所等顶尖科研院所继续读博深造。

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代表性纵向项目

1.国家科技部基础资源调查专项子课题，承担感染相关念珠菌病毒资源本底调查任务,主持,60万

2. 国家自然基金面上项目“养殖猪场废水中噬菌体介导的耐药基因传播机制研究”,主持,58万

3.国家自然青年基金“粪肥施用菜田系统中抗生素抗性基因的增殖与迁移机制研究”,主持,25万

4. 陕西省高层次人才引进计划，青年项目“噬菌体资源的开发与应用” ,主持,30万

5.北京自然科学基金面上项目“粪肥-土壤-蔬菜系统中抗生素抗性基因的来源及其水平转移研究” ,主持,25万

6.中国博士后一等基金“生物阴极型微生物燃料电池中微生物与电极材料相互作用机制的研究”, 主

持,5万

7.北京市农林科学院青年基金“粪肥-土壤-蔬菜系统中抗生素抗性基因的分布特征研究” ,主持,20万

8. “超富硒植物堇叶碎米荠内生菌及其硒代谢机理研究”, 北京市重点实验室开放课题,主持,3万

9. 微生物资源的开发与应用，西北大学科研启动项目，主持,20万

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代表性横向项目

1. 具有****的乳酸菌及其在**中的应用研究，2022年12月，主持，99万

2. 中国人群头皮和皮肤护理益生菌开发，2022年11月，主持，45万

3. 伊利**自有******菌基础性能研究，2022年12月，主持，28万

4. 基于*****的产孢机制优化**杆菌的产孢研究，主持，25万

5. ****球菌 Yilife－SST 01基础应用研究，主持，16万

(根据甲方要求，隐藏项目部分名称，结题后陆续公开)

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近五年代表性科研论文

[1] Yong Yang#, Guangming Zhang#, Jie Pan, Zhen Zhang, Ning Mao, Shiwei Wang*, Yanmei Sun*. Characterization of fluoranthene degradation by the novel isolated Pseudomonas xizangensis S4 and its application potential immobilized in potassium humate-modified biochar. Bioresource Technology. 2025, 419, 132066. 通讯作者

[2] Guangming Zhang, Baolei Li, Yong Yang, Zhen Zhang, Furong Wang, Ziyi Wei, Ning Mao, Shiwei Wang*, Xiaobo Liu*, Yanmei Sun*. Biodegradation of humic acids by Streptomyces rochei to promote the growth and yield of corn. Microbiological Research 2024, 286: 127826.  通讯作者

[3] Yanmei Sun, Dongmei Xu, Guangming Zhang,Wenjing Wu, Weina Kong, Zisheng Guo, Bentao Xiong, Shiwei Wang*, Xuejin Zhao*. Wild type Escherichia coli Nissle 1917 improves hyperuricemia by anaerobically degrading uric acid and maintaining gut microbiota profile of mice. Journal of Functional Foods. 2024,112:105935. 第一作者

[4] Jie Pan, Zhuhong You, Wencai You, Tian Zhao, Chenlu Feng, Xuexia Zhang, Fengzhi Ren, Sanxing Ma, Fan Wu, Yanmei Sun*, Shiwei Wang*. A microbial knowledge graph－based deep learning model for predicting candidate microbes for target hosts. Briefings in Bioinformatics 2024,25(3): 119.  通讯作者

[5] Jie Pan, Guangming Zhang, Yong Yang, Wenli Yang, Ning Mao, Zhuhong You, Jie Feng, Shiwei Wang*, Yanmei Sun*. MHIPM: Accurate Prediction of Microbe-Host interactions Using Multi-View Features from Heterogeneous Microbial Network. Journal of Chemical Information and Modeling. 2024,14;64(19):7793-7805.  通讯作者

[6] Jie Pan, Zhuhong You, Wencai You, Tian Zhao, Chenlu Feng, Xuexia Zhang, Fengzhi Ren, Sanxing Ma, Fan Wu, Shiwei Wang*, Yanmei Sun*. PTBGRP: predicting phage bacteria interactions with graph representation learning on microbial heterogeneous information network. Briefings in Bioinformatics 2023,24(6):328.  通讯作者

[7] Guangming Zhang, Yong Yang, Miao Dou, Jie Pan, Jialu Du, Zhen Zhang, Ning Mao, Lingtao    Luo, Shiwei Wang*, Yanmei Sun*. Integrative insights into benzo[a]pyrene degradation mechanisms by Aspergillus fumigatus Z5: spectroscopic, transcriptomic,and computational biological analyses. Journal of Environmental Sciences. 2025. 2025. 157, 866–878  通讯作者

[8] Jie Pan, Rui Wang, Wenjing Liu, Li Wang, Zhuhong You, Yuechao Li, Zhemeng Duan, Qinghua Huang, Jie Feng, Yanmei Sun*, Shiwei Wang*. Predicting phage－host interaction via hyperbolic Poincare graph embedding and large-scale protein language technique. iScience. 2025.28,111647.  通讯作者

[9] Shuo Liu#, Yun Xie#, Chenyu Li#, Guangming Zhang, Xin Wang, Huarui Zhao, Hui Chang, Baochao Hou, Weilian Hung, Jian He, Baolei Li, Zisheng Guo*, Yanmei Sun*, Shiwei Wang*. Antiosteoporosis activity and mechanism analyses of Limosilactobacillus fermentum YSC5001 from Chinese traditional dairy products. Journal of Functional Foods 2025,130:106905.  通讯作者

[10] Guang Guo, Fang Tian, Liping Zhang, Keqiang Ding, Feng Yang, Zhixin Hu, Chong Liu, Yanmei Sun*, Shiwei Wang. Effect of salinity on removal performance in hydrolysis acidification reactors treating textile wastewater. Bioresource Technology. 2020, 313:123652.  通讯作者

[11] Yanmei Sun#, Yajie Guo#, Mingming Shi, Tianlei Qiu, Min Gao, Shulei Tian, Xuming Wang*. Effect of antibiotic type and vegetable species on antibiotic accumulation in soil－vegetable system, soil microbiota, and resistance genes. Chemosphere 2020, 128099:263－271. 第一作者

[12] Yanmei Sun, Jia Gua, Fu Wei, Xiaohui Chen, Meng Li, Chao Li, Size Xia, Guangming Zhang, Wencai You, Xin Cong, Tian Yu*, Shiwei Wang*. Microbial functional communities and the antibiotic resistome profile in a high-selenium ecosystem. Chemosphere 2023, 311(1):136858.第一作者

[13] Nana Lu#, Yanmei Sun#, Qingqin Wang, Yi Qiu, Zhi Chen, Ying Wen, Shiwei Wang, Yuan Song. Cloning and characterization of endolysin and holin from Streptomyces avermitilis bacteriophage phiSASD1 as potential novel antibiotic candidates. International Journal of Biological Macromolecules. 2020, 147:980－989. 并列第一作者 

[14] Jie Pan, Wencai You, Xiaoliang Lu, Shiwei Wang, Zhuhong You, and Yanmei Sun*. GSPHI: A novel deep learning model for predicting phage-host interactions via multiple biological information. Computational and Structural Biotechnology Journal. 2023; 21: 3404–3413. 通讯作者

[15] Chao Li, Xiuping Lin, Shiwei Wang, Da Guan, Xiaofang Wang, Bin Yang, Xuefeng Zhou, Jianfang Li, Bentao Xiong, Yonghong Liu, Yanmei Sun* A New Brominated Isocoumarin from the Marine Starfish-Associated Fungus Aspergillus sp. WXF1904. Chemistry & Biodiversity. 2024, 21(2):e202301706. 通讯作者

[16] Pan, Jie, Shiwei Wang, Changqing Yu, Liping Li, Zhuhong You, and Yanmei Sun* A Novel Ensemble Learning Based Computational Method to Predict Protein Protein Interactions from Protein Primary Sequences. Biology. 2022,11(5):775. 通讯作者

[17] Zisheng Guo#, Bin Zhu#, Jia Guo#, Gongting Wang, Meng Li, Qiaoli Yang, Liping Wang, Yue   Fei, Shiwei Wang, Tian Yu*, Yanmei Sun*. Impact of selenium on rhizosphere microbiome of a hyperaccumulation plant Cardamine violifolia. Environmental Science and Pollution Research. 2022, 29(26):40241－40251. 通讯作者

[18] Yanmei Sun#, Wei Chen#, Shiwei Wang*, Xiaoli Cao*. Co occurrence of fosA5, blaSHV 145 And blaOXA 48 among a Klebsiella pneumoniae high risk ST16 from a tertiary hospital in China: focusing on the phylogeny of OXA 48 genes from global Klebsiella pneumoniae isolates. Brazilian Journal of Microbiology 2021,52(4):2559－2563. 第一作者

[19] Yanmei Sun, Guang Guo, Fang Tian, Huihai Chen, Weijie Liu, Meng Li, Shiwei Wang*. Antibiotic resistance genes and bacterial community on the surfaces of five cultivars of fresh tomatoes. Ecotoxicology, 2020, 13: 1-7. 第一作者

[20] TianYu, JiaGuo, SongZhu, MengLi, ZhenzhouZhu, ShuiyuanCheng, Yanmei Sun*, Xin Cong*.  Protective effects of selenium-enriched peptides from cardamine violifolia against high fat diet induced obesity and its associated metabolic disorders in mice. RSC Advances 2020,10, 31411.  通讯作者

[21] Weiyi Liu#, Fang Wang#, Yanmei Sun#, Lei Yang, Huihai Chen, Weijie Liu, Bin Zhu, Chaomao Hui, Shiwei Wang. Influence of dragon bamboo with different planting patterns on microbial community and physicochemical property of soil at sunny and shady slopes. Journal of Microbiology 2020, 12275:82-88. 并列第一作者

[22] Chong Wang, Li Wang, Chongbin Bai, Mingpeng Wang, Tao Ma, Honglin Ma, Guangming Zhang, Weiwei Wang, Zisheng Guo, Yanmei Sun*, Shiwei Wang*. Identification of the key factors influencing biodeterioration of open-air cultural heritage in the temperate climate zone of China. International Biodeterioration & Biodegradation. 2025,196,105954.  通讯作者

 

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代表性专利

1. 肠杆菌和菌剂以及其应用，孙艳梅，王利平，魏福，夏思哲，郭子晟，王世伟. ZL2022 1 0516679.4，2022年5月
2. 噬菌体和杀菌组合物及应用，孙艳梅，王卫富，田利明，闫军军，翁婧，陈富林，王世伟.ZL 2023 1 0243578.9，2025年2月
3.娄彻氏链霉菌及其在增加农作物产量中的应用，孙艳梅,张光明,杨勇,赵瑜,孔伟娜,王世伟. CN202311089083.1,2025年2月
4.邻吡酮C，其制备方法及其应用，孙艳梅，李超，林秀萍，王世伟. CN117964594A,2024年5月
5.一株广谱抑菌副干酪乳酪杆菌A-2及其应用，孙艳梅，魏福，张光明，郭子晟，王世伟. 2025107460752

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成果转化

1.富硒菌剂的专利菌及其技术，1件，转让恩施本心农业科技有限公司，转化20万元，2024年6月。

邮编 : 991446b01997572aed4488b9bcf769f68a019001bf1adcfe29ffe26048b4004e2a2963c656555f81cf7e776fcce84ced0f0abe16cb3dae41a0fa210eb616f6c1e175ff0872677ef3dc07b8281f98c3f0414c032a3ccbc66b155eb451e7be42fa86577ffdf4a6667c5b7d597a9ccb648aa783f1c4dccb610d11036d4657a42e19

通讯/办公地址 : b896c52967288f0cb16f58fe705971d101a1cad36aab1e264e2f7b70694ce3179338ffe742e5fa184e325895c0d58f02d2ed394ed7876f5fd0a4f1aab35de58f0bd186fd62136379871b667fea2b4248896bc7d023335e43ac8a8df2755fc287ae9df64f93a28098907527a7eb09319ada9e19bf16d5736eb23f9134dc2e117f

[1] 中国农业大学       微生物学       博士研究生毕业       博士学位

[2] 清华大学       研究生(博士后)

[1] 2013.9 -- 2014.8
北京铁汉生态环境科学研究院      研究人员

[2] 2015.1 -- 2016.3
美国东卡罗莱纳大学      生命科学学院      博士后

[3] 2017.6 -- 2019.12
北京市农林科学院      生物技术研究中心      助理研究员

[4] 2020.1 -- 至今
生命科学学院      助理研究员三级      副教授      现任

捕食性微生物（噬菌体）

环境微生物