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疾病糖蛋白质组学，主要研究方向：
1) 建立基于生物质谱分析的糖蛋白质组样品制备和质谱分析新方法；
2) 开发高精度糖蛋白质组学分析的软件系统，为破译糖质的生命密码提供关键技术支撑；
3) 将组学新技术应用于重大疾病特别是恶性肿瘤生物标志物和治疗靶点的发现研究，并开展重要糖蛋白的功能及发病机制研究。
- 83. Zhida Zhang, Yongqi Wu, Ke Hou, Yiwen Zhang, Lin Chen, Muyao Yang, Zhehui Jin, Yongchao Xu, Yingjie Zhang, Yinli Cai, Jiayu Zhao, Shisheng Sun*. A Glycoproteome Data Mining Strategy for Characterizing Structural Features of Altered Glycans with Thymic Involution. Advanced Science, 2025, Accepted. 2025,
- 82. Miaomiao Xin, Yintai Xu, Shanshan You, Cheng Li, Jiechen Shen, Bojing Zhu, Qiaohong Zhao, Juanzi Shi*, Shisheng Sun*. Structural and site-specific characterization of distinctive N-glycans with heavy fucosylation in human semen. Carbohydrate Polymer Technologies and Applications. 2025, Accepted
- 81. Yongqi Wu, Zhida Zhang, Yongchao Xu, Yingjie Zhang, Lin Chen, Yiwen Zhang, Ke Hou, Muyao Yang, Zhehui Jin, Yinli Cai, Jiayu Zhao, Shisheng Sun*. A High-resolution N-Glycoproteome Landscape of Aging Mouse Ovary. Redox Biology. 2025, 81: 103584.
- 80. Jun Li, Didi Liu, Yingjie Zhang, Zhehui Jin, Yue Xue, Shisheng Sun*. High-abundance serum glycoproteins as valuable resources for glycopeptide standards. Carbohydrate Polymers. 2025, 347: 122746.
- 79. Pengyu Ren, Longhui Fu, Xiaojuan Gong, Li Jia, Boqiang Lyu, Mengke Wang, Siyuan Zhang, Shisheng Sun, Na Zhao, Zongben Xu, Jie Zhu*. Heterogeneities of Site-Specific N-Glycosylation in the Hippocampus of Depression-like Behavior Models in Mice Induced by Acute Stress and Chronic Stress. Journal of Proteome Research, 2025, 24(3):1039–1052.
- 78. Mingjun Hu, Kaiyue Xu, Ge Yang, Bo Yan, Qianqian Yang, Liang Wang, Shisheng Sun*, Huijuan Wang*. Integrated proteomics and N-glycoproteomic characterization of glioblastoma multiform revealed N-glycosylation heterogeneities as well as alterations in sialyation and fucosylation. Clinical Proteomics, 2025, 22(1): 6.
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