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高精度糖蛋白质组学，包括：建立基于生物质谱分析的高精度糖蛋白质组学新方法、开发高通量自动化糖链结构解析的新软件、并用于重大疾病特别是恶性肿瘤生物标志物和治疗靶点发现研究。
- 77. Didi Liu, Yue Xue, Dan Ding, Bojing Zhu, Jiechen Shen, Zhehui Jin, Shisheng Sun*. Distinct O-Acetylation Patterns of Serum Glycoproteins Among Humans, Mice and Rats. Journal of Proteome Research. 2024, 23, 5511−5519. 2024,
- 76. Didi Liu#, Jun Li#, Yue Xue, Ting Zhao, Zhehui Jin, Wei Dan, Zexuan Chen, Liangshuo Hu, Shisheng Sun*. Site-Specific N-glycan Alterations on Haptoglobin as Potential Biomarkers for Distinguishing Intrahepatic Cholangiocarcinoma from Hepatocellular Carcinoma. International Journal of Biological Macromolecules. 2024, 280: 135563.
- 75. Jun Li, Didi Liu, Yingjie Zhang, Zhehui Jin, Yue Xue, Shisheng Sun*. High-abundance serum glycoproteins as valuable resources for glycopeptide standards. Carbohydrate Polymers. 2025, 347: 122746.
- 74. Jun Li#, Didi Liu#, Yingjie Zhang, Jiechen Shen, Wei Dan, Zexuan Chen, Shisheng Sun*. Site-specific analysis of core and antenna fucosylation on serum glycoproteins. Analytical Chemistry. 2024,96(15): 5741-45.
- 73. Miaomiao Xin#, Cheng Li#, Shanshan You, Bojing Zhu, Jiechen Shen, Wenbo Dong, Xia Xue, Wenhao Shi, Yao Xiong, Juanzi Shi, Shisheng Sun*. Site-specific N-glycoproteomic analysis reveals up-regulated fucosylation in seminal plasma of asthenozoospermia. Glycobiology. 2024, 34(9): cwae054.
- 72. Yongqi Wu#, Zhida Zhang#, Lin Chen, Shisheng Sun*. Immunoglobulin G glycosylation and its alterations in aging-related diseases. Acta Biochimica et Biophysica Sinica. 2024, 56(8): 1221–1233.
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