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疾病糖蛋白质组学，主要研究方向：
1) 建立基于生物质谱分析的糖蛋白质组样品制备和质谱分析新方法；
2) 开发高精度糖蛋白质组学分析的软件系统，为破译糖质的生命密码提供关键技术支撑；
3) 将组学新技术应用于重大疾病特别是恶性肿瘤生物标志物和治疗靶点的发现研究，并开展重要糖蛋白的功能及发病机制研究。
- 86. Zhida Zhang, Ke Hou, Mengyu Liu, Tong Li, Muyao Yang, Han Hao, Zhuangzhuang Feng, Yongqi Wu, Ye Zhao*, Shisheng Sun*. Structural and site-specific N-glycan alterations define the glycoproteomic landscape of thymic aging in rats. Carbohydrate Polymers, 2025, 370: 124447.
- 85. Qiudi Ye, Jiechen Shen, Bojing Zhu, Zexuan Chen, Xiguo Yuan*, Shisheng Sun*. Precise Monoisotopic Peak Assignment of Intact Glycopeptides Using Partial Average Mass Matching. Analytical Chemistry. 2025, 97(36): 19456–19465.
- Xiuxiao Tang#, Ranran Dai#, Li Qing#, Zhida Zhang#, Lizi Lu, Hancheng Lin, Wei Dan, Yuqi He, Xinyi Liu, Wakam Chang, Yang Mao, Shisheng Sun*, Junjun Ding*. Nuclear polysaccharides maintain H3K9me3-heterochromatin and genomic stability. BioRxiv, August 12, 2025. doi.org/10.1101/2025.08.12.669888 [预印本]
- 84. Zhida Zhang, Yongqi Wu, Ke Hou, Yiwen Zhang, Lin Chen, Muyao Yang, Zhehui Jin, Yongchao Xu, Yingjie Zhang, Yinli Cai, Jiayu Zhao, Shisheng Sun*. A Glycoproteome Data Mining Strategy for Characterizing Structural Features of Altered Glycans with Thymic Involution. Advanced Science, 2025, 12(38): e02013. 2025,
- Yongqi Wu#, Muyao Yang#, Yongchao Xu#, Li Jia#, Jun Li, Xiaohan Wang, Jiayu Zhao, Yinli Cai, Yiwen Zhang, Shisheng Sun*. A High-Resolution N-Glycoproteome Atlas Reveals Tissue-Specific Glycan Remodeling but Non-random Structural Microheterogeneities. BioRxiv, June 26, 2025. doi.org/10.1101/2025.06.24.661310 [预印本]
- 83. Yongqi Wu, Zhida Zhang, Yongchao Xu, Yingjie Zhang, Lin Chen, Yiwen Zhang, Ke Hou, Muyao Yang, Zhehui Jin, Yinli Cai, Jiayu Zhao, Shisheng Sun*. A High-resolution N-Glycoproteome Landscape of Aging Mouse Ovary. Redox Biology. 2025, 81: 103584.
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