张博

个人信息:Personal Information



教师拼音名称:zhangbo

电子邮箱:

入职时间:2023-02-24

所在单位:医学院

职务:教授

办公地点:医学楼-北楼316室

学位:博士学位

毕业院校:拉瓦尔大学医学院(加拿大)

学科:生物化学与分子生物学
细胞生物学
生物物理学

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个人简介Personal Profile

教育背景:

11/2009 – 05/2014:博士,生理学与内分泌学专业,拉瓦尔大学医学院 (加拿大);

09/2004 – 07/2007:硕士,生物物理学专业,河北工业大学;

09/1997 – 07/2001:学士,飞行器设计与工程专业,北京航空航天大学;


主要工作经历:

02/2023 –              :   教授,医学院,生命科学与医学部,西北大学;

12/2018 – 01/2023:副研究员,生命科学学院,福建师范大学;

08/2017 – 11/2018:讲师,生命科学学院,福建师范大学;

08/2014 – 01/2017:博士后,中国科学院生物物理研究所;


主要文献发表情况:(共同第一作者加注上标"#", 共同通讯作者加注上标"*"

1.  Bo Zhang#, Jinying Lin#, Vanja Perčulija#, Yu Li, Jing Chen, Qiuhua Lu and Songying Ouyang*. Structural insights into target DNA recognition and cleavage by the CRISPR-Cas12c1 system. Nucleic Acids Research, 2022, 50(20):11820-11833. (SCI 12021年影响因子19.160)

2.  Bo Zhang#, Diyin Luo#, Yu Li#, Vanja Perčulija, Jing Chen, Jinying Lin, Yangmiao Ye and Songying Ouyang*. Mechanistic insights into the R-loop formation and cleavage in CRISPR-Cas12i1. Nature Communications, 2021, 12(3476):1-13. (SCI 1区,2021年影响因子:17.694)

3.  Vanja Perčulija, Jinying Lin, Bo Zhang* and Songying Ouyang*. Functional features and current applications of the RNA-targeting type VI CRISPR-Cas systems. Advanced Science, 2021, 2004685:1-23. (SCI 1区,2021年影响因子:17.521)

4.  Bo Zhang#, Yangmiao Ye#, Weiwei Ye, Vanja Perčulija, Han Jiang, Yiyang Chen, Yu Li, Jing Chen, Jinying Lin, Siqi Wang, Qi Chen and Songying Ouyang*. Two HEPN domains dictate CRISPR RNA maturation and target cleavage in Cas13d. Nature Communications, 2019, 10(2544):1-11. (SCI 1区,2019年影响因子:12.121)

5.  Bo Zhang#, Weiwei Ye#, Yangmiao Ye, Huan Zhou, Abdullah F.U.H. Saeed, Jing Chen, Jinying Lin, Vanja Perčulija, Qi Chen, Chun-Jung Chen, Ming-Xian Chang, Muhammad Iqbal Choudhary and Songying Ouyang*. Structural insights into Cas13b-guided CRISPR RNA maturation and recognition. Cell Research, 2018, 28(12):1198-1201. (SCI 1区,2018年影响因子:17.848)

6.  Bo Zhang, Xiao-Jian Hu, Xiao-Qiang Wang, Jean-Francois Theriault, Dao-Wei Zhu, Peng Shang, Fernand Labrie, Sheng-Xiang Lin*. (2016). Human 3-alplha hydroxysteroid dehydrogenase type 3: structural clues of 5α-DHT reverse binding and enzyme down-regulation decreasing MCF7 cell growth. Biochemical Journal, 2016, 473(8):1037-1046. (SCI 2区,2016年影响因子:3.797)

7.  Bo Zhang, Dao-Wei Zhu, Xiao-Jian Hu, Ming Zhou, Peng Shang, Sheng-Xiang Lin*. (2014). Human 3-alpha hydroxysteroid dehydrogenase type 3 (3α-HSD3): the V54L mutation restricting the steroid alternative binding and enhancing the 20α-HSD activity. Journal of Steroid Biochemistry and Molecular Biology, 2014, 141: 135-143. (SCI 3区,2014年影响因子:3.628)

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