专业方向：化学生物学；生物化工；应用化学

研究兴趣：衰老靶向识别与干预；生物体系分子探针；药物化学生物学；有机化学/化工

个人简介：

郭媛，西北大学教授、博士生导师；兼任西安市科协常务委员、法国奥尔良大学特邀研究员；本、硕、博毕业于西北大学；先后在第四军医大学、法国国家科研中心奥尔良ICOA研究所做博士后研究。主讲本科生《有机化学》、研究生《化学生物学》等课程；荣获西北大学第八届青年教师讲课比赛一等奖、西北大学化学与材料科学学院讲课比赛特等奖、陕西省微课程教学比赛三等奖；主讲的公益课程在《道来》栏目在线发布并获中国学位与研究生教育学会授予的公益荣誉表彰。

长期聚焦生物学衰老精准识别与干预开展化学生物学、生物化工等交叉领域科学研究；先后主持国家自然科学基金项目 6 项；以通讯作者在Nat. Aging、Angew. Chem. Int. Ed.、Adv. Sci.、Chem. Sci.、Anal. Chem.等国际知名学术刊物上发表SCI论文六十余篇；获授权发明专利十余项；获陕西省杰出青年科学基金资助；获西安市三八红旗手、西安青年科技人才称号；作为主要完成人获陕西省科学技术一等奖、三等奖；担任Acta Materia Medica、Chinese Chemical Letters、《精细化工》等学术期刊编委。

Biography:  

Dr. Yuan GUO is a professor and graduate supervisor at Northwest University, where she plays a key role in advancing research and education. She teaches foundational and advanced courses, including Organic Chemistry for undergraduate students and Chemical Biology for graduate students. She is an active member of the Standing Committee of the Xi'an Association for Science and Technology. Professor Guo completed her studies including PhD at Northwest University. She later conducted postdoctoral research at the Fourth Military Medical University in China and at the ICOA Institute of the French National Center for Scientific Research (CNRS). She also served as a special research fellow at the University of Orleans in France. 

Her dedication to education has earned her multiple accolades, including: First Prize in the 8th Young Teachers Lecture Competition at Northwest University; Special Prize in the lecture competition at the School of Chemistry and Materials Science; Third Prize in the Shaanxi Micro-Course Teaching Competition.

Professor Guo's research focuses on the precise identification and intervention of biological aging, integrating insights from chemical biology and biochemical engineering. She has led six projects funded by the National Natural Science Foundation of China and published over 60 papers in high-impact journals, such as Nature Aging, Angewandte Chemie International Edition, Advanced Science, Chemical Science, and Analytical Chemistry. She is also a prolific innovator, holding more than ten invention patents.

Professor Guo taught a public welfare course which was featured in the “Dao Lai” series and was awarded public welfare honors by the China Association for Degree and Graduate Education. She has received the Shaanxi Outstanding Youth Science Fund and was named Xi'an March 8th Red Flag Bearer as well as Xi'an Youth Science and Technology Talent. As a key contributor, she has received both first and third prizes in the Shaanxi Science and Technology Awards. Professor Guo is an editorial board member for several prestigious journals, including Acta Materia Medica, Chinese Chemical Letters, and Fine Chemicals, where she contributes to advancing research in her field.

Recent Publications：

38. Fang Yuan, Aoxin Guo, Lu Wang, Lulu Ning, Yuan Guo* and Jianjian Zhang*. Tunable light-activated platform for controlled hydrogen sulfide release with tracking. Angewandte Chemie International Edition, 2025, 64, e202501685.

https://doi.org/10.1002/anie.202501685.

37. Guangwei Wang, Fang-Fang Guo, Jiaojiao Wu, Liang-Liang Gao, Xinrong Tian, Jianjian Zhang* and Yuan Guo*. A near-infrared fluorescent probe for the detection of vicinal-dithiol-containing proteins and its application in vivo. Sensors and Actuators B: Chemical, 2025, 443, 138235.

https://doi.org/10.1016/j.snb.2025.138235

36. Da Feng, Li Guo, Yihan Zhao, Fang Yuan, Lulu Ning, Yuan Guo* and Jianjian Zhang*. pH-/Viscosity-Activatable NIR Fluorescent Probes via Acceptor Engineering of Hemicyanine Dyes for High-Contrast Bioimaging. Analytical Chemistry, 2025, 97, 4041-4048.

https://doi.org/10.1021/acs.analchem.4c05680

35. Xu Qu, Baohua Ji, Haocheng Cheng, Guangwei Wang, Liang-Liang Gao, Jing Zhang*, Jianjian Zhang*, Yuan Guo*. Dual-emissive near-infrared fluorogenic probe with enhanced cellular uptake capability for sensitive tracking of cellular polarity. Chinese Chemical Letters, 2025, 36, 110766.

https://doi.org/10.1016/j.cclet.2024.110766

34. Xinhang Lv, Yangxin Yu, Zhuowei Chen, Guangwei Wang, Xiaokang Li, Ling Sun, Lingyu Wu, Jiale Wu, Jian Li*, Yuan Guo* and Donglei Shi*. Molecular engineering development of β-galactosidase-activatable fluorogenic probes for precise senescence tracking in cells, tissues and a mouse model of psoriasis. Sensors and Actuators B: Chemical, 2025, 444, 138406.  Online 时间：2025年7月28日

https://doi.org/10.1016/j.snb.2025.138406

33. Shulin Pang, Jiaojiao Wu, Fang-Fang Guo, Liang-Liang Gao, Xinrong Tian, Jianjian Zhang* and Yuan Guo*. Fluorogenic chemical probe strategy for precise tracking of mitochondrial polarity. Analytical Chemistry, 2024, 96, 14800-14808.

https://doi.org/10.1021/acs.analchem.4c02364.

32. Jiqun Wang, Wenwen Liu, Yunyuan Huang, Guangwei Wang, Xiaobo Guo, Donglei Shi, Tianyue Sun, Chaojiang Xiao, Chao Zhang, Bei Jiang*, Yuan Guo* and Jian Li*. A senomorphlytic three-drug combination discovered in Salsola collina for delaying aging phenotypes and extending healthspan. Advanced Science, 2024,  11, 2401862.

https://doi.org/10.1002/advs.202401862.

31. Fang Yuan, Suya Zhang, Yue Wang, Xuan Gao, Yihan Zhao, Lulu Ning, Yuwei Wang, Yuan Guo* and Jianjian Zhang*. Activatable near-infrared fluorescence probe for hypochlorous acid detection in early diagnosis of keloids. Analytical Chemistry, 2024, 96, 16964-16970.

https://doi.org/10.1021/acs.analchem.4c04201.

30. Xu Qu, Pengzhao Wu, Kaixuan Duan, Guangwei Wang, Liang-Liang Gao, Yuan Guo*, Jianjian Zhang* and Donglei Shi*. Self-calibrating probes constructed on a unique dual-emissive fluorescence platform for the precise tracking of cellular senescence. Chinese Chemical Letters, 2024, 35, 109681.

https://doi.org/10.1016/j.cclet.2024.109681.

 

29. Donglei Shi, Wenwen Liu, Ying Gao, Xinming Li, Yunyuan Huang, Xiaokang Li, Tony D. James, Yuan Guo* and Jian Li*. Photoactivatable senolysis with single-cell resolution delays aging. Nature Aging, 2023, 3, 297-312. 

https://doi.org/10.1038/s43587-023-00360-x.

      Yuan Guo* and Jian Li*. A senolytic strategy integrating multiple technologies delays aging. Nature Aging, 2023, 3, 244-245.  (Related Research Briefing)

https://doi.org/10.1038/s43587-023-00369-2.

 

28. Haocheng Gong, Yanhui Zhang, Ying Gao, Xinrong Tian, Pengzhao Wu, Xiaoyu Wei and Yuan Guo*. In vivoprecision imaging of vicinal-dithiol-containing proteins by a FRET molecular probe sensitive to protein environment. Chinese Chemical Letters, 2023, 34, 108329.

https://doi.org/10.1016/j.cclet.2023.108329.

 

27. Yihe Song, Xinming Li, Donglei Shi, Tianyue Sun, Wenwen Liu, Xiaokang Li, Sicong Qiao, Xin Chen, Yuan Guo* and Jian Li*. A senolysis-based theragnostic prodrug strategy towards chronic renal failure. Chemical Science, 2022, 13, 11738-11745. (Back cover)

https://doi.org/10.1039/D2SC03525A.

 

26. Wanzhen Yang, Yanhui Zhang, Hao Teng, Na Liu, Chunquan Sheng* and Yuan Guo*. Role of azole drugs in promoting fungal cell autophagy revealed by an NIR fluorescence-based theranostic probe. Analytical Chemistry, 2022, 94, 7092-7099.

https://doi.org/10.1021/acs.analchem.2c00859.

 

25. Xinrong Tian, Jin Li, Yanhui Zhang, Ying Gao, Muhammad Wasim Afzal, Aoli Wang, Tony D. James, Yinjuan Bai* and Yuan Guo*. A spiropyran with low pK_a for tracking DNA G-quadruplexes and revealing the dissipation of ΔΨm with senescence using an in-situ switching strategy. Sensors and Actuators B: Chemical, 2022, 359, 131618.

https://doi.org/10.1016/j.snb.2022.131618.

 

24. Xinming Li, Donglei Shi, Yihe Song, Yixiang Xu, Ying Gao, Wenjing Qiu, Xin Chen, Xiaokang Li, Yunyuan Huang, Yanjun Feng, Baoli Li*, Yuan Guo* and Jian Li*. Specific tracking of monoamine oxidase A in heart failure models by a far-red fluorescent probe with an ultra large Stokes shift. Chinese Chemical Letters, 2022, 33, 1572-1576.

https://doi.org/10.1016/j.cclet.2021.08.114.

 

23. Muhammad Wasim Afzal, Shixiong Wang, Ying Gao, Bo Qin, Xinrong Tian, Yanhui Zhang, Haoyang Tang and Yuan Guo*. A highly water-soluble rhodol-based fluorescent probe for the organic-solvent independent sensing of biological hypochlorous acid. Dyes and Pigments, 2022, 204, 110435.

https://doi.org/10.1016/j.dyepig.2022.110435.

 

22. Muhammad Wasim Afzal, Kaixuan Duan, Yanhui Zhang, Ying Gao, Bo Qin, Guangwei Wang, Lin Lei, Haoyang Tang* and Yuan Guo*. A rhodol-based fluorescent probe with a pair of hydrophilic and rotatable wings for sensitively monitoring intracellular polarity. Chemistry-An Asian Journal, 2022, 17, e202200063. (VIP paper)

https://doi.org/10.1002/asia.202200063.

 

21. Donglei Shi, Wenwen Liu, Guangwei Wang, Yuan Guo* and Jian Li*. Small-molecule fluorescence-based probes for aging diagnosis. Acta Materia Medica, 2022, 1, 4-23.

https://doi.org/10.15212/AMM-2021-0004.

 

20. Liang-Liang Gao, Shulin Pang, Ying Gao, Donglei Shi* and Yuan Guo*. Recent development of organic small-molecule and nanomaterial fluorescent probes for hydrazine. Advanced Agrochem, 2022, 1, 22-38.

https://doi.org/10.1016/j.aac.2022.08.003.

 

19. Ying Gao, Yulu Hu, Qimeng Liu, Xiaokang Li, Xinming Li, Chu-Young Kim, Tony D. James, Jian Li*, Xi Chen* and Yuan Guo*. Two-dimensional design strategy to construct smart fluorescent probes for the precise tracking of senescence. Angewandte Chemie International Edition, 2021, 60, 10756-10765.

https://doi.org/10.1002/anie.202101278.

 

18. Jingye Tian, Donglei Shi, Yanhui Zhang, Xiaokang Li, Xinming Li, Hao Teng, Tony D. James, Jian Li* and Yuan Guo*. Stress response decay with aging visualized using a dual-channel logic-based fluorescent probe. Chemical Science, 2021, 12, 13483-13491.

https://doi.org/10.1039/D1SC04162B.

 

17. Ying Wu, Yanhui Zhang, Xi Chen, Yulu Hu, Guoqiang Dong, Yuan Guo* and Chunquan Sheng*. A theranostic probe of indoleamine 2,3-dioxygenase 1 (IDO1) for small molecule cancer immunotherapy. European Journal of Medicinal Chemistry, 2021, 213, 113163.

https://doi.org/10.1016/j.ejmech.2021.113163.

 

16. Haoyang Tang, Xinyu Qiang, Ying Gao, Hao Teng*, Xi Chen, Yanhui Zhang, Jingye Tian, Bo Qin and Yuan Guo*. Real-time tracking and dual-mode imaging of hypochlorous acid in vivo by a small-sized fluorescence probe. Dyes and Pigments, 2021, 188, 109219.

https://doi.org/10.1016/j.dyepig.2021.109219.

 

15. Xiaokang Li, Wenjing Qiu, Jinwen Li, Xi Chen, Yulu Hu, Ying Gao, Donglei Shi, Xinming Li, Huiling Lin, Zelan Hu, Guoqiang Dong, Chunquan Sheng, Bei Jiang, Conglong Xia, Chu-Young Kim, Yuan Guo* and Jian Li*. First-generation species-selective chemical probes for fluorescence imaging of human senescence-associated β-galactosidase. Chemical Science, 2020, 11, 7292-7301. (Front cover)

https://doi.org/10.1039/D0SC01234C.

 

14. Donglei Shi, Linghao Hu, Xinming Li, Wenwen Liu, Ying Gao, Xiaokang Li, Bei Jiang, Conglong Xia, Yuan Guo* and Jian Li*. Lysosomal polarity increases with aging as revealed by a lysosome-targetable near-infrared fluorescent probe. Sensors and Actuators B: Chemical, 2020, 319, 128302.

https://doi.org/10.1016/j.snb.2020.128302.

 

13. Hao Teng, Jingye Tian, Donghuan Sun, Mengxue Xiu, Yanhui Zhang, Xingyu Qiang, Haoyang Tang* and Yuan Guo*. A mitochondria-specific fluorescent probe based on triazolopyridine formation for visualizing endogenous hypochlorous acid in living cells and zebrafish. Sensors and Actuators B: Chemical, 2020, 319, 128288.

https://doi.org/10.1016/j.snb.2020.128288.

 

12. Yanhui Zhang, Hao Teng, Ying Gao, Muhammad Wasim Afzal, Jingye Tian, Xi Chen, Haoyang Tang, Tony D. James and Yuan Guo*. A general strategy for selective detection of hypochlorous acid based on triazolopyridine formation. Chinese Chemical Letters, 2020, 31, 2917-2920. (Front cover)

https://doi.org/10.1016/j.cclet.2020.03.020.

 

11. Linghao Hu, Donglei Shi, Xinming Li, Jin Zhu, Fei Mao, Xiaokang Li, Conglong Xia, Bei Jiang, Yuan Guo* and Jian Li*. Curcumin-based polarity fluorescent probes: Design strategy and biological applications. Dyes and Pigments, 2020, 177, 108320.

https://doi.org/10.1016/j.dyepig.2020.108320.

 

10. Donglei Shi, Shuqiang Chen, Biao Dong, Yanhui Zhang, Chunquan Sheng, Tony D. James and Yuan Guo*. Evaluation of HOCl-generating anticancer agents by an ultrasensitive dual-mode fluorescent probe. Chemical Science, 2019, 10, 3715-3722. (Back Cover)

https://doi.org/10.1039/C9SC00180H.

 

9. Jin Li, Xinchi Yin, Bin Li, Xiaokang Li, Yuanjiang Pan, Jian Li and Yuan Guo*. Spiropyran in situ switching: A real-time fluorescence strategy for tracking DNA G-quadruplexes in live cells. Analytical Chemistry, 2019, 91, 5354-5361.

https://doi.org/10.1021/acs.analchem.9b00436.

 

8. Qimeng Liu, Anyang Li, Xiaokang Li, Bin Li, Yanhui Zhang, Jian Li and Yuan Guo*. Selective visualization of live-cell mitochondrial thiophenols and their induced oxidative stress process by a rationally designed rhodol-based fluorescent probe. Sensors and Actuators B: Chemical, 2019, 283, 820-830.

https://doi.org/10.1016/j.snb.2018.12.090.

 

7. Jin Li, Ying Gao, Haoran Guo, Xiaokang Li, Haoyang Tang, Jian Li and Yuan Guo*. A novel colorimetric and ratiometric fluorescent probe for selective detection of bisulfite in real samples and living cells. Dyes and Pigments, 2019, 163, 285-290.

https://doi.org/10.1016/j.dyepig.2018.12.009.

 

6. Jin Li, Xiaokang Li, Jianbo Jia, Xi Chen, Yinjuan Lv, Yuan Guo* and Jian Li*. A ratiometric near-infrared fluorescence strategy based on spiropyran in situ switching for tracking dynamic changes of live-cell lysosomal pH. Dyes and Pigments, 2019, 166, 433-442.

https://doi.org/10.1016/j.dyepig.2019.03.060.

 

5. Qimeng Liu, Huan Wang, Haoran Guo and Yuan Guo*. A highly selective coumarin-based fluorescent probe for detecting Fe³⁺ in pure water systems and living cells. Chinese Journal of Inorganic Chemistry, 2019, 35, 923-929.

https://doi.org/10.11862/CJIC.2019.090.

 

4. Huan Wang, Donglei Shi, Jin Li, Haoyang Tang, Jian Li and Yuan Guo*. A facile fluorescent probe with a large Stokes shift for sequentially detecting copper and sulfide in 100% aqueous solution and imaging them in living cells. Sensors and Actuators B: Chemical, 2018, 256, 600-608.

https://doi.org/10.1016/j.snb.2017.10.124.

 

3. Haoyang Tang, Ying Gao, Bin Li, Changwei Li and Yuan Guo*. Reaction-based colorimetric and ratiometric fluorescent probe for highly selective detection of silver ions. Sensors and Actuators B: Chemical, 2018, 270, 562-569.

https://doi.org/10.1016/j.snb.2018.05.064.

 

2. Yanhui Zhang, Lin Ma, Chunchao Tang, Shengnan Pan, Donglei Shi, Shaojing Wang, Minyong Li* and Guo Yuan*. A highly sensitive and rapidly responding fluorescent probe based on a rhodol fluorophore for imaging endogenous hypochlorite in living mice. Journal of Materials Chemistry B, 2018, 6, 725-731. (Front cover)

https://doi.org/10.1039/C7TB02862H.

 

1. Shaojing Wang, Jin Li, Ying Gao and Yuan Guo*. Highly selective and sensitive 2-(2’-hydroxyphenyl) benzothiazole-based turn-on fluorescent probes for detecting and imaging bisulfite in living cells. Asian Journal of Organic Chemistry, 2018, 7, 563-569.

https://doi.org/10.1002/ajoc.201700626.