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针对创新药物研发的重大需求，聚焦如何在复杂样品中发现新药先导化合物和如何创造高活性候选化合物两个科学问题，以受体色谱新方法的创建和应用为突破口，开展受体色谱新技术、中药等复杂体系受体靶向活性成分高效筛选、药物-蛋白质相互作用三个方面研究。
受体色谱创建及应用示意图
- An emerging paradigm to develop analytical methods based on immobilized transmembrane proteins and its applications in drug discovery TrAC-Trends in Analytical Chemistry 2022, 157,
- Covalent immobilization of beta2 adrenergic receptor through trans-methylation reaction by SNAP-tag and its application in anti-asthmatic compound screening from Raphani Semen Journal of Pharmaceutical and Biomedical Analysis 2022, 219,
- Preparation and characterization of immobilized 5-HT1A receptor stationary phase for high throughput screening of the receptor-binding ligands from complex systems like Curcuma wenyujin Y. H. Chen et C. Ling extract Journal of Pharmaceutical and Biomedical Analysis 2022, 211,
- Site-selective covalently immobilized alpha 1A adrenergic receptor for thermodynamic and extra-thermodynamic study of four ligands binding to the receptor by chromatographic methods Journal of Chromatography A 2022, 1665,
- Development of immobilized beta1-adrenoceptor chromatography for rapid discovery of ligands specifically binding to the receptor from herbal extract Journal of Chromatography A 2022, 1677,
- Screening of bioactive flavour compounds targeting muscarinic-3 acetylcholine receptor from Siraitia grosvenorii and evaluation of their synergistic anti-asthmatic activity Food Chemistry 2022, 395,