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    曹利平

    • 教授 博士生导师 硕士生导师
    • 教师拼音名称:caoliping
    • 所在单位:化学与材料科学学院
    • 学历:博士研究生毕业
    • 办公地点:西北大学长安校区化学与材料科学学院618室
    • 联系方式:chcaoliping@nwu.edu.cn
    • 在职信息:在职
    • 毕业院校:华中师范大学
    • 学科:无机化学
      有机化学

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    个人简介

    本科和博士毕业于华中师范大学化学学院,获华中师范大学优秀博士论文;2011年-2014年在美国马里兰大学从事博士后研究;2014年以人才引进加入西北大学化学与材料科学学院,任教授、博导。独立工作期间,先后荣获西北大学青年学术骨干、陕西省青年百人计划、Thieme Chemistry Journals Award、教育部霍英东青年教师基金、陕西省杰出青年科学基金、国家自然科学基金委优秀青年科学基金;主持包括国家自然科学基金面上项目(3项)、陕西省自然科学基金面上项目(1项)和陕西省教育厅重点科研计划(1项)等科研项目。主要从事大环超分子化学领域的研究工作,先后开展了水相超高强度分子识别、水相主客体荧光材料、新型水溶性大环分子的合成与生物分子识别应用等方面的研究;迄今以第一或通讯作者发表J. Am. Chem. Soc., Angew. Chem. Int. Ed., CCS Chem.等期刊论文四十余篇;相关研究成果获陕西高等学校科学技术研究优秀成果一等奖(排名第一)和陕西省自然科学一等奖(排名第三)


    学习和工作经历:

    2014年-今:教授,博导,西北大学,化学与材料科学学院。

    2017年-2018年:国家公派访问学者,美国犹他大学,化学系,合作导师:Peter Stang教授。 

    2011年-2014年:博士后,美国马里兰大学,化学与生物化学系,合作导师:Lyle Isaacs教授。

    2006年-2011年:理学博士(有机化学),华中师范大学,化学学院,导师:吴安心教授。

    2002年-2006年:理学学士(应用化学),华中师范大学,化学学院。

     

    基金项目:

    2021年:国家自然科学基金委优秀青年科学基金

    2021年:陕西省杰出青年科学基金

    2020年:教育部霍英东高校青年教师基金

    2016年:陕西省百人计划(青年项目)

    2015年:西北大学优秀青年学术骨干计划


    荣誉奖项:

    2022年:陕西高等学校科学技术研究优秀成果一等奖(排名第一)

    2022年:陕西省自然科学一等奖(排名第三)

    2021年:西北大学2021年度科研奖

    2021年:西北大学优秀博士学位论文指导教师

    2020年:西北大学优秀硕士学位论文指导教师

    2020年:西北大学2019-2020教学年度优秀教师

    2020年:Thieme Chemistry Journals Award

    2011年:华中师范大学优秀博士论文


    学术兼职:

    中国感光学会青年理事会理事(2021)

    《Aggregate》青年顾问编委(2020)

    《Chinese Chemical Letter》高级编委(2021-2025)

    《Chinese Chemical Letter》青年编委(2020-2022)


    研究方向:

    1、新颖水溶性阳离子型荧光大环分子的合成及生物分子识别研究;

    2、基于大环分子识别的刺激响应型超分子组装体系的建立与应用;

    3、基于大环的超分子框架材料:构筑、性质研究以及功能的应用。


    曹利平.jpg

    近年来,课题组针对当前生物分子识别准确性差、手性信息响应缺失等难点和瓶颈问题,通过开发水溶性大环超分子人工体系,系统开展了生物分子识别与手性响应机制的新原理和新方法研究,提出了自适应手性识别与响应的机理,实现了氨基酸、核苷、多肽、蛋白质以及DNA等生物分子的选择性识别与手性信号响应,为生物分子检测与监测机制研究建立了一类人工仿生识别的超分子体系。

     

    毕业学生:

    博士毕业生

    2019年:鱼洋(西安交通大学)

    2021年:李亚雯(西安交通大学)、王聘聘(枣庄学院)

    2022年:程琳(西北大学)

    硕士毕业生

    2017年:李杰

    2018年:王聘聘(西北大学)

    2019年:张蓓琳(西北工业大学)

    2020年:李晨阳(陕西能源职业技术学院)、段红红(西北大学)

    2021年:年浩(南方科技大学)、张海洋(陕西隆基乐叶光伏科技有限公司)、秦春艳(山西稷王中学)

    2022年:段燕娟(天津凯莱英医药)、王玲

    本科毕业生

    2020年:敖宛彤(丹麦哥本哈根大学),金慧琳(比利时布鲁塞尔自由大学)


    科研成果:

    独立工作(2014-今): 

    46.  Duan, Y.; Wang, J.; Cheng, L.; Duan, H.; Tian, P.; Zhang, Y.*; Cao, L.,* Fluorescent, Chirality-Responsive, and Water-Soluble Cage as a Multifunctional Molecular Container for Drug Delivery. Org. & Biomole. Chem. 2022, 20, 3998-4005

    https://pubs.rsc.org/en/content/articlelanding/2022/ob/d2ob00520d

    TOC-0112-7副本.jpg

    45. Li, Y.; Yan, C.; Li, Q.; Cao, L.,* Successive Construction of Cucurbit[8]uril-Based Covalent Organic Frameworks from a Supramolecular Organic Framework through Photochemical Reactions in Water. Sci. China Chem. 2022, 65, 1279-1285.

    http://engine.scichina.com/doi/10.1007/s11426-022-1231-5

     TOC.jpg


    44. Cheng, L.; Tian, P.; Li, Q.; Li, A.; Cao, L.,* Stabilization and Multiple-Responsive Recognition of Natural Base Pairs in Water by a Cationic Cage.  CCS Chem. 2021, 3, 3608-3614. 

    https://www.chinesechemsoc.org/doi/10.31635/ccschem.021.202101584

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    43. Wang, P.; Liu, K.; Ma, H.; Nian, H.; Li, Y.; Li, Q.; Cheng, L.; Cao, L.,* Synthesis and Aqueous Anion Recognition of Imidazolium-Based Nonacationic Cup. Chem. Commun. 2021, 57, 13377-13380. 

    https://pubs.rsc.org/en/content/articlehtml/2021/CC/D1CC05603D

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    42. Duan, H.; Cao, F.; Zhang, M.; Gao, M.; Cao, L.,* On-off-on fluorescence detection for biomolecules by a fluorescent cage through host-guest complexation in water. Chin. Chem. Lett. 2022, 33, 2459-2463. 

    https://www.sciencedirect.com/science/article/pii/S1001841721009426

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    41. Nian, H.; Cheng, L.; Wang, L.; Zhang, H.; Wang, P.; Li, Y.; Cao, L.,* Hierarchical Two-Level Supramolecular Chirality of an Achiral Anthracene-Based Tetracationic Nanotube in Water. Angew. Chem. Int. Ed. 2021, 60, 15354-15358. 

    https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/anie.202105593

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    40.  Qin, C.; Li, Y.; Li, Q.; Yan, C.; Cao, L.,*  Aggregation-Induced Emission and Self-Assembly of Functional Tetraphenylethene-Based Tetracationic Dicyclophanes for Selective Detection of ATP in Water.  Chin. Chem. Lett. 2021, 32, 3531-3534. 

    https://www.sciencedirect.com/science/article/pii/S1001841721003107

    1-s2.0-S1001841721003107-fx1.jpg

    39. Xu, W.; Duan, H.; Chang, X.; Wang, G.; Hu, D.; Wang, Z.; Cao, L.*; Fang, Y.,* Polyanion and Anionic Surface Monitoring in Aqueous Medium Enabled by an Ionic Host-Guest Complex. Sensors and Actuators B: Chemical, 2021, 340, 129916. 

    https://www.sciencedirect.com/science/article/pii/S0925400521004858

    D70F07639530D9D8BA5CB72B1B3D05DE.png

    38. Duan, H.; Cao, F.; Hao, H.; Bian, H.; Cao, L.,* Efficient Photoinduced Energy and Electron Transfers in a Tetraphenylethene-Based Octacationic Cage through Host-Guest Complexation. ACS Appl. Mater. & Interfaces 2021, 13, 16837-16845.

    https://pubs.acs.org/doi/10.1021/acsami.1c01867

    TOC-122520.jpg

    37. Zhang, H.; Cheng, L.; Nian, H.; Du, J.; Chen, T.; Cao, L.,* Adaptive Chirality of Achiral Tetraphenylethene-Based Tetracationic Cyclophanes with Dual Responses of Fluorescence and Circular Dichroism in Water. Chem. Commun. 2021, 57, 3135-3138. 

    https://doi.org/10.1039/d1cc00303h

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    36. Li, Y.; Li, Q.; Miao, X.; Qin, C.; Chu, D.; Cao, L.,* Adaptive Chirality of an Achiral Cucurbit[8]uril-Based Supramolecular Organic Framework for Chirality Induction in Water. Angew. Chem. Int. Ed. 2021,  60, 6744-6751. 

    https://doi.org/10.1002/anie.202012681

    TOC-111020.jpg

    35. Cheng, L.; Liu, K.;  Duan, Y.; Duan, H.;  Li, Y.;  Gao, M.; Cao, L.,* Adaptive Chirality of an Achiral Cage: Chirality Transfer, Induction, and Circularly Polarized Luminescence Through Aqueous Host-Guest Complexation. CCS Chem. 2020, 2, 2749-2751. 

    https://www.chinesechemsoc.org/doi/abs/10.31635/ccschem.020.202000509                           

    TOC-121020.jpg

    34. Duan, H.; Li, Y.; Li, Q.; Wang, P.; Liu, X.; Cheng, L.; Yu, Y.; Cao, L.,* Host-Guest Recognition and Fluorescence of a Tetraphenylethene-Based Octacationic Cage. Angew. Chem., Int. Ed. 2020, 59, 10101-10110.

    https://doi.org/10.1002/anie.201912730

    19.gif

    33.  Wang, P.; Miao, X.; Meng, Y.; Wang, Q.; Wang, J.*; Duan, H.; Li, Y.; Li, C.; Liu, J.; Cao, L.,* Tetraphenylethene-Based Supramolecular Coordination Frameworks with Aggregation-Induced Emission for Artificial Light-Harvesting System. ACS Appl. Mater. & Interfaces 2020, 12, 22630-22639.

    https://pubs.acs.org/doi/pdf/10.1021/acsami.0c04917

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    32. Li, Y.; Qin, C.; Li, Q.; Wang, P.; Miao, X.; Jin, H.; Ao, W.; Cao, L.* Supramolecular Organic Frameworks with Controllable Shape and Aggregation-Induced Emission for Tunable Luminescent Materials Through Aqueous Host-Guest Complexation. Adv. Opt. Mater. 2020, 1902154. 

    https://onlinelibrary.wiley.com/doi/abs/10.1002/adom.201902154

     17.gif

    31. Nian, H.; Li, A.; Li, Y.; Cheng, L.; Wang, L.; Xu, W.; Cao, L.,* Tetraphenylethene-Based Tetracationic Dicyclophanes: Synthesis, Mechanochromic Luminescence, and Photochemical Reaction. Chem. Commun. 2020, 56, 3195-3198. 

    https://doi.org/10.1039/d0cc00860e

     16.gif

    30. Li, C.; Nian, H.; Dong, Y.*; Li, Y,; Zhang, B.; Cao, L.,* Tetraphenylethene-Based Platinum(II) Bis-Triangular Dicycles with Tunable Emissions.  Inorg. Chem. 2020, 59, 5713-5720.

    https://pubs.acs.org/doi/abs/10.1021/acs.inorgchem.0c00505

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    29. Li, C.; Zhang, B.; Dong, Y.*; Li, Y.; Wang, P.; Yu, Y.; Cheng, L.; Cao, L.* A Tetraphenylethene-Based Pd2L4 Metallacage with Aggregation-Induced Emission and Stimuli-Responsive Behavior. Dalton Trans. 2020, 49, 8051-8055.

    https://pubs.rsc.org/en/content/articlelanding/2020/DT/D0DT00469C#!divAbstract

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    28. Li, Y.; Dong, Y.; Cheng, L.; Qin, C.; Nian, H.; Zhang, H.; Yu, Y.; Cao, L.,* Aggregation-Induced Emission and Light-Harvesting Function of Tetraphenylethene-Based Tetracationic Dicyclophane. J. Am. Chem. Soc. 2019, 141, 8412-8415

    https://doi.org/10.1021/jacs.9b02617

    27. Cao, L.*; Wang, P.; Miao, X.; Duan, H.; Wang, H.; Dong, Y.; Ma, R.; Zhang, B.; Wu, B.; Li, X.; Stang, P. J., Diamondoid Frameworks via Supramolecular Coordination: Structural Characterization, Metallogel Formation, and Adsorption Study. Inorg. Chem. 2019, 58, 6268-6275.

    https://pubs.acs.org/doi/10.1021/acs.inorgchem.9b00484

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    26. Cheng, L.; Zhang, H.; Dong, Y.; Zhao, Y.; Yu, Y.; Cao, L.* Tetraphenylethene-Based Tetracationic Cyclophanes and Their Selective Recognition for Amino Acids and Adenosine Derivatives in Water. Chem. Commun. 2019, 55, 2372 - 2375.

    https://pubs.rsc.org/en/content/articlepdf/2019/cc/c9cc00599d

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    25. Zhang, B.; Dong, Y.; Li, J.; Yu, Y.; Li, C.; Cao, L.,* Pseudo[n,m]rotaxanes of Cucurbit[7/8]uril and Viologen-Naphthalene Derivative: A Precise Definition of Rotaxane. Chin. J. Chem. 2019, 37, 262-275.

    https://onlinelibrary.wiley.com/doi/10.1002/cjoc.201800562

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    24. 李亚雯; 敖宛彤; 金慧琳; 曹利平,* 四苯乙烯衍生物与大环主体在主客体相互作用下的聚集诱导发光, 化学进展, 2019, 31,121-133. 

    https://manu56.magtech.com.cn/progchem/CN/abstract/abstract12175.shtml

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    23. Cao, L.*; Wang, P.; Miao, X.; Dong, Y.; Wang, H.; Duan, H.; Yu, Y.; Li, X.; Stang, P. J.,* Diamondoid Supramolecular Coordination Frameworks from Discrete Adamantanoid Platinum(II) Cages. J. Am. Chem. Soc. 2018, 140, 7005-7011. 

    https://pubs.acs.org/doi/10.1021/jacs.8b03856

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    22. Li, Y.; Dong, Y.; Miao, X.; Ren, Y.; Zhang, B.; Wang, P.; Yu, Y.; Li, B.; Isaacs, L.; Cao, L.,* Shape-Controllable and Fluorescent Supramolecular Organic Frameworks through Aqueous Host–Guest Complexation. Angew. Chem., Int. Ed.2018, 57, 729-733. 

    https://onlinelibrary.wiley.com/doi/pdf/10.1002/anie.201710553

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    21. Yu, Y.; Li, Y.; Wang, X.; Nian, H.; Wang, L.; Zhao, Y.; Li, J.; Yang, X.; Liu, S.*; Cao, L.,* Cucurbit[10]uril-based [2]Rotaxane: Preparation and Supramolecular Assembly-Induced Fluorescence Enhancement. J. Org. Chem. 2017, 82, 5590-5596. 

    http://pubs.acs.org/doi/pdfplus/10.1021/acs.joc.7b00400

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    20. Wang, P.; Wu, Y.; Zhao, Y.; Yu, Y.; Zhang, M.*; Cao, L.* Crystalline Nanotubular Framework Constructed by Cucurbit[8]uril for Selective CO2 Adsorption. Chem. Commun. 2017, 53, 5503-5506. 

    http://pubs.rsc.org/en/content/articlepdf/2017/cc/c7cc02074k

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    19. Li, J.; Zhao, Y.; Dong, Y.; Yu, Y.; Cao, L.*; Wu, B., Supramolecular Organic Frameworks of Cucurbit[n]uril-Based [2]Pseudorotaxanes in the Crystalline State. CrystEngComm, 2016, 18, 7929-7933.

    http://pubs.rsc.org/en/content/articlepdf/2016/ce/c6ce01320a

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    18. Dong, Y.; Cao, L.,* Functionalization of Cucurbit[n]uril. Progress in Chemistry,(化学进展 2016, 28, 1039-1053.

    https://manu56.magtech.com.cn/progchem/CN/10.7536/PC160320

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    17. Li, J.; Yu, Y.; Luo, L.; Li, Y.; Wang, P.; Cao, L.*; Wu, B., Square [5]Molecular Necklace Formed from Cucurbit[8]uril and Carbazole Derivative. Tetrahedron Lett. 2016, 57, 2306-2310.

    https://www.sciencedirect.com/science/article/pii/S0040403916304105?via%3Dihub

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    16. Yu. Y.; Li, J.; Zhang, M.; Cao, L.*; Isaacs, L.,* Hydrophobic Monofunctionalized Cucurbit[7]Uril Undergoes Self-Inclusion Complexation and Forms Vesicle-Type Assemblies. Chem. Commun. 2015, 51, 3762-3765. 

    http://pubs.rsc.org/en/content/articlepdf/2015/cc/c5cc00236b

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    博士后期间工作(2011-2014): 

    15. Sigwalt, D.; Sekutor, M.; Cao, L.; Zavalij, P. Y.; Hostas, J.; Ajani, H.; Hobza, P.; Mlimaric-Majerski, K.*; Glaser, R.*; Isaacs, L.* Unraveling the Structure-Affinity Relationship between Cucurbit[n]urils (n = 7, 8) and Cationic Diamondoids. J. Am. Chem. Soc. 2017, 139, 3249-3258. (SCI, IF = 13, 一区top)

     

    14. Cao, L.; Skalamera, D.; Zavalij, P. Y.; Hobza, P.*; Mlinarić-Majerski, K.*; Glaser R.*; Isaacs, L.* Influence of Hydrophobic Residues on the Binding of CB[7] toward Diammonium Ions of Common Ammonium•••ammonium Distance. Org. Biomol. Chem. 201513, 6249-6254. (SCI, IF = 3.5)

     

    13. Cao, L.; Šekutor, M.; Zavalij, P. Y.; Mlinarić-Majerski, K.*; Glaser R.*; Isaacs, L.* Cucurbit[7]uril.Guest Pair with an Attomolar Dissociation Constant. Angew. Chem., Int. Ed. 201453, 988-993. (SCI, IF = 13.4, VIP paper and Poster of the frontispiece, 一区top)

     

    12. Zhang, M.#; Cao, L.# (共同第一作者); Isaacs, L.* Cucurbit[6]Uril-Cucurbit[7]Uril Heterodimer Promotes Controlled Self-Assembly Of Supramolecular Networks And Supramolecular Micelles By Self-Sorting Of Amphiphilic Guests. Chem. Commun. 2014, 50, 14756-14759. (SCI, IF = 6.7, 一区)

     

    11. Cao, L.; Isaacs,L.* Absolute and Relative Binding Affinity of Cucurbit[7]uril Towards A Series of Cationic Guests. Supramol. Chem. 2014, 26, 251-258. (SCI, IF = 2.1)


    10. Cao, L.; Hettiarachchi, G.; Briken, V.*; Isaacs, L.* Cucurbit[7]uril Containers for Targeted Delivery of Oxaliplatin to Cancer Cells. Angew. Chem., Int. Ed. 201352, 12033-12037. (SCI, IF = 13.4, 一区top)

     

    9. Vinciguerra, B.#; Cao, L.# (共同第一作者); Cannon, J. R.; Zavalij, P. Y.; Fenselau, C.; Isaacs, L.* Synthesis and Self-Assembly Processes of Monofunctionalized Cucurbit[7]uril. J. Am. Chem. Soc. 2012134, 13133-12140. (SCI, IF = 11.4, 一区top) (Spotlights on Recent JACS Publications, J. Am. Chem. Soc. 2012134, 14265-14266.)


    8. Cao, L.; Isaacs, L.* Daisy Chain Assembly Formed from a Cucurbit[6]uril Derivative. Org. Lett. 201214, 3072-3075. (SCI, IF = 6.3, 一区)


    7. Lucas, D.; Minami, T.; Iannuzzi, G.; Cao, L.; Wittenberg, J. B.; Anzenbacher, Jr. P.*; Isaacs, L.* Templated Synthesis of Glycoluril Hexamer and Monofunctionalized Cucurbit[6]uril Derivatives. J. Am. Chem. Soc. 2012, 134, 13133-12140. (SCI, IF = 11.4)


    博士期间工作(2006-2011): 

    6. Cao, L.; Wang, J. G.; Ding, J. Y.; Wu, A. X.*; Isaacs,L.* Reassembly Self-Sorting Triggered by Heterodimerization. Chem. Commun. 2011, 47, 8548-8550. (SCI, IF = 6.7, 一区)

     

    5. Cao, L.; Meng, X. G.; Ding, J. Y.; Chen, Y. F.; Gao, M.; Wu, Y. D.; Li, Y. T.; Wu, A. X.*; Isaacs, L.* Nanotubular Non-Covalent Macrocycle Within Non-Covalent Macrocycle Assembly: (MeOH)(12) Encapsulated in Amolecular Clip Cyclododecamer. Chem. Commun. 2010, 46, 4508-4510. (SCI, IF = 6.7)

     

    4. Cao, L.; Ding, J. Y.; Gao, M.; Wang, Z. H.; Li, J.; Wu, A. X.* Novel and Direct Transformation of Methyl Ketones or Carbinols to Primary Amides by Employing Aqueous Ammonia. Org. Lett. 2009, 11, 3810-3813. (SCI, IF = 6.3) (highlighted by Organic Chemistry Portal: http://www.organic-chemistry.org/abstracts/lit2/649.shtm; ChemInform, 2010, 41, DOI:10.1002/chin.201004082)

     

    3. Cao, L.; Ding, J. Y.; Wang, J. G.; Chen, Y.; Gao, M.; Xue, W. J.; Wu, A. X.* Colorimetric Fluoride Sensor Based on a Bisthiourea Functionalized Molecular Clip. Synlett 2010, 2553-2556. (SCI, IF = 2.8)

     

    2. Cao, L.; Ding, J. Y.; Yin, G. D.; Gao, M.; Li, Y. T.; Wu, A. X.* Thioglycoluril as a Novel Organocatalyst: Rapid and Efficient alpha-Monobromination of 1,3-Dicarbonyl Compounds. Synlett. 2009, 1445-1448. (SCI, IF = 2.8)

     

    1. 曹利平; 高蒙; 李义涛; 丁娇阳; 吴彦东; 祝艳平; 佘能芳; 吴安心* 二元组装体集群时的高选择性杂化重组行为. 中国科学B辑: 化学, 2009, 39, 343-349. (国家核心期刊)

     

    参与编写专著 

    1. Cao, L.; Zhao, J.; Yang, D.; Yang, X.-J.; Wu, B.* Hydrogen Bonding-Driven Anion Recognition in Hydrogen Bonded Supramolecular Structures. Springer-Verlag Berlin Herdelberg, 2015, DOI:10.1007/978-3-662-45756-6_5.

     

    *通讯作者(Corresponding author)


    其他联系方式

    邮编 :

    通讯/办公地址 :

    邮箱 :

    教育经历

    [1] 2006.9 -- 2011.5
    华中师范大学       有机化学       博士研究生毕业       理学博士学位

    [2] 2002.9 -- 2006.7
    华中师范大学       应用化学       大学本科毕业       理学学士学位

    工作经历

    [1] 2014.5 -- 至今
    西北大学      教授

    [2] 2017.7 -- 2018.7
    犹他大学      访问学者

    [3] 2011.5 -- 2014.5
    马里兰大学      博士后