吴少平，博士，西北大学教授。2011年获CSC奖学金赴法国巴黎第六大学（现法国索邦大学）攻读博士学位；2015年7月加入西北大学生命科学学院；近年来主持和参与国家级项目、省部级项目及横向课题20余项；在 Anal. Chem., Sens. Actuators B, Food Chem., Eur. J. Med. Chem.和 Anal. Chim. Acta.等期刊发表论文 60 余篇， 影响因子（IF）> 5.0 共20余篇，单篇最高引用次数140余次，H因子20；2016年获第十一届陕西青年科技奖；2017年入选陕西省高层次人才项目；西北大学优秀教师；学部青年教师讲课比赛三等奖获得者；第三届陕西省侨联青年委员会委员；西北大学第五届侨联委员；教育部“创新团队发展计划”项目计划骨干成员（2017年）；陕西省高校青年创新团队项目“肿瘤糖生物学及糖类药物设计”骨干成员（2019年）；“三秦学者”药物-生命效应分析科学创智创新团队骨干成员（2021年）；深圳市、河南省、江西省科技项目评审专家；全国专业学位水平评估专家；Acta Materia Medica青年编委；《中国药业》编委；Sensors and Actuators B， Eur. J. Med. Chem.等国际期刊审稿人；先后指导本科生获得全国大学生生命科学创新创业大赛一等奖两次（2018年，2020年），二等奖一次（2019年）；第十二届西安高新“挑战杯”陕西省大学生课外学术科技作品竞赛二等奖（2019年）；“互联网⁺”大赛省级铜奖（2022年，2023年）两次等。

研究兴趣：1、药物合成新工艺及新方法研究、类天然产物骨架的设计合成及其构效关系研究；

                 2、功能有机分子的设计合成及应用；

                 3、康养美容保健系列产品开发。

诚挚邀请：具有药物化学、化学大类、生命科学、材料科学研究背景的优秀学子加盟！

代表性发明专利：

     1.  四氢萘酮作为近红外荧光探针在脂滴成像中的应用（授权号：CN114790388B）；

     2.  一种近红外AIE碳点及其制备方法和其在三重防伪和铝离子检测中的应用（授权号：CN116730324B）；

     3. 一种在酸性和高脂肪性油污下具有强起泡能力的茶皂素双子表面活性剂（授权号：CN114805467B）；

     4. 一种碳基固体酸催化剂及其催化茶皂素制备茶皂苷元的方法（授权号：CN114950480B）。

代表性论文成果：

24. W. Q. Zhao, S. T. Zhang, J. L. Yan, P. Y. Xu, B. Li*, Y. M. Zhang, J. L. Li, S. P. Wu*. A dual-emission fluorescent probe for simultaneous detection of singlet oxygen and hypochlorous acid in lipid droplets. Sensor. Actuat. B-Chem. 2024, 412, 135813.(IF：8.40，Top期刊)

23.  W. Q. Zhao, P. Y. Xu, Y. X. Ma, Y. M. Song*, Y. H. Wang, P. P. Zhang, B. Li, Y. M. Zhang, J. L. Li, S. P. Wu*. Old trees bloom new flowers, lysosome targeted near-infrared fluorescent probe for ratiometric sensing of hypobromous acid in vitro and in vivo based on Nile red skeleton. Bioorg. Chem. 2024, 143, 107031. (IF: 5.10)

22. Q. Feng, Y. M. Song, Y. X. Ma, X. Y. Wang, P. Y. Xu, K. J. Sheng, Y. M. Zhang, J. L. Li, S. P. Wu*. Molecular engineering of benzenesulfonyl analogs for visual hydrogen polysulfide fluorescent probes based on Nile red skeleton. Spectrochim. Acta. A 2023,  296, 122658. (IF: 4.831)

21. L. Wu, B. Li, Y. Deng, J. Y. Zhou, G. Y. Shi, Y. H. Li, X. Q. Wang, S. P. Wu*, Y. M. Zhang, J. L. Li. Synthesis and application of visual AIE fluorescent probe for lipid droplets in vivo.  Dyes Pigments. 2023, 209, 110946. (IF: 5.122, Top期刊)

 

    

20. S. T. Zhang, B. Li, J. Y. Zhou, J. Y. Shi, Z. J. He, Y. M. Zhao, Yan Li**, Y. H. Shen**, S. P. Wu*. Kill three birds with one stone: Mitochondria-localized tea saponin derived carbon dots with AIE properties for stable detection of HSA and extremely acidic pH. Food Chem. 2023, 405, 134865. (IF: 9.22,  Top期刊)

19. X. A. Li, T. T. Guo, Q. Feng, T. T. Bai, L. Wu, Y. B. Liu, X. Zheng, J. Z. Jia, J. Pei, S. P. Wu*, Y. M. Song*, Y. M. Zhang. Progress of thrombus formation and research on the structure-activity relationship for antithrombotic drugs. Eur. J. Med. Chem. 2022, 228, 114035. (IF: 7.09, Top期刊)

18.  K. J. Sheng, Y. M. Song, F. Lei, W. Q. Zhao, L. M. Fan, L. Wu, Y. B. Liu, S. P. Wu*, Y. M. Zhang. Research progress in pharmacological activities and structure-activity relationships of tetralone scaffolds as pharmacophore and fluorescent skeleton. Eur. J. Med. Chem. 2022, 227, 113964. (IF: 7.09, Top期刊)

17. X. L. Li, Q. Feng, L. J. Qu, T. Zhao, X. A. Li, T. T. Bai, S. S. Sun, S. P. Wu*, Y. M. Zhang, J. L. Li. A water-soluble and incubate-free fluorescent environment-sensitive probe for ultrafast visualization of protein thiols within living cells. Anal. Chim. Acta. 2020, 1126, 61-74. (IF：6.91, Top期刊)

16. Z. F. Zhao, S. S. Ruan, X. M. Ma, Q. Feng, Z. S. Xie, Z. Nie, P. N. Fan, M. C. Qian, X. R.He, S. P. Wu*, Y. M. Zhang, X. H. Zheng. Challenges Faced withSmall Molecular Modulatorsof Potassium Current Channel Isoform Kv1.5. Biomolecules. 2020, 10, doi:10.3390/biom10010010. (IF：6.06)

15. L. L. Yang, S. S. Ruan, A. Q. Zhang, M. Y. Hu, J. Zhang, K. J. Sheng, J. Tian, Y. M. Zhang, S. P. Wu*, J. L. Li. A colorimetric and ratiometricfluorescent probe with meldrum’s acid as the recognition group for in vitro and in vivo imaging of hypochlorite. Dyes Pigments. 2020, 175, 108144. (IF：5.12, Top期刊)

 

14. Z. F. Zhao, X. F. Dai, C. Y. Li, X. Wang, J. L. Tian, Y. Feng, J. Xie, C. Ma, Z. Nie, P. N. Fan, M. C. Qian, X. R. He, S. P. Wu*, X. H. Zheng, Y. M. Zhang. Pyrazolone Structural Motif in Medicinal Chemistry: Retrospect and Prospect. Eur. J. Med. Chem. 2020, 186, 111893. (IF：7.09, Top期刊)

13. J. L. Du, X. L. Li, S. S.Ruan, Y. C. Li, F. Ren, Y. J. Cao, X. Q. Wang, Y. M. Zhang, S. P. Wu^⁎, J. L. Li. Rational design of a novel turn-on fluorescent probe for detecting hydrazine with barbituric acid as recognition group and bioimaging. Analyst. 2020, 145, 636-642. (IF：5.23)

12. Z. F. Zhao, L. Wu, J. Xie, Y. Feng, J. L. Tian, X. R. He, B. Li, L. Wang, X. M.Wang, Y. Y. Zhang, S. P. Wu^⁎, X. H. Zheng. Rhodomyrtustomentosa (Aiton.): A review of phytochemistry, pharmacology and industrial applications research progress. Food Chem. 2020, 309, 125715.  (IF：9.22, Top期刊)

11. Z. F. Zhao, Y. J. Bai, J.Xie, X. F. Chen, X. R. He^⁎, Y. Sun, Y. J. Bai, Y. Y. Zhang, S. P. Wu^⁎, X. H. Zheng. Excavating precursors from the traditional Chinese herb Polygala tenuifoliaand Gastrodiaelata: Synthesis, anticonvulsant activity evaluation of 3,4,5-trimethoxycinnamic acid (TMCA) ester derivatives. Bioorg. Chem. 2019, 88, 102832.  (IF：5.31, Top期刊)

10. Z. F. Zhao, H. H. Song, J.Xie, T. Liu, X. Zhao, X. F. Chen, X. R. He, S. P. Wu*, Y. M. Zhang, X. H. Zheng*. Research progress in the biological activities of 3,4,5-trimethoxycinnamic acid (TMCA) derivatives. Eur. J. Med. Chem. 2019, 173, 213-227. (IF：7.09, Top期刊)

9. Z. F. Zhao, X. R. He,W. Han, X. F. Chen, P. L. Liu, X. Zhao, X. Wang, L. X. Zhang, S. P. Wu*, X. H. Zheng*. Genus Tetradium L. A comprehensive review on traditional uses, phytochemistry, and pharmacological activities. J. Ethnopharmacology. 2019, 231, 337-354. (IF：5.19, Top期刊 )

8. L. L. Yang, M. F. Liu, K. J. Sheng, X. L. Li, J. L. Du, Y. Y. Ning, X. Q. Wang, S. P. Wu*. Design and synthesis of a novel colorimetric fluorescent probe for selective detection of sulfur dioxide in SH-SY5Y neuroblastoma cells and its application in Traditional Chinese Medicines. New J. Chem. 2019, 43, 4188-4195. (IF：3.92)

7. Y. Y. Ning, X. Q. Wang, K. J. Sheng, L. L. Yang, C. N. Xiao, C. N. Xiao, S. P. Wu*. A novel colorimetric and fluorescent turn-on pH sensor with notably large Stokes shift for its application. New J. Chem. 2018, 42, 14510-14516.  (IF：3.92)

6. Y. Y. Ning, J. H. Cui, Y. W. Lu, X. Q. Wang, C. N. Xiao, S. P. Wu*. De novo design and synthesis a novel colorimetric fluorescent probe based on naphthalenone scaffold for the selective detection of hypochlorite and its application in living cells. Sensor.Actuat. B-Chem. 2018, 269, 322-330. (IF：9.22, Top期刊)

5. M. Y. She^†, S. P. Wu^†, Z. H. Wang, S. Y. Ma, Z. Yang, B. Yin, P. Liu, S. Y. Zhang, J. L. Li*. Exploration of congeneric Hg(II)-mediated chemosensorsdriven by S-Hg affinity, and their application in living system  Sensor. Actuat. B-Chem. 2017, 247, 129-138. (Co-first authors) (IF：9.22, Top期刊)

4. S. P. Wu, L. L. Yang, W. J. Sun, L. l. Si, S. L. Xiao, Q. Wang, S. Thorimbert, L. Dechoux, M. Sollogoub, D. M. Zhou, Y. M. Zhang. Design, synthesis and biological evaluation of gentiopicroside derivatives as potential antiviral inhibitors. Eur. J. Med. Chem. 2017, 130, 308-319. (IF：7.09, Top期刊)

3. X. L. Jin^†, S. P. Wu^†, M. Y. She, Y. F. Jia, L. K. Hao, B. Yin, L. Y. Wang, M. Obst, Y. H. Shen, Y. M. Zhang, J. L. Li. A novel fluorescein-based fluorescent probe for detecting H2S and its real applications in blood plasma and biological imaging. Anal. Chem. 2016, 88, 11253-11260. (Co-first authors)（IF：6.32, Top期刊）

2．S. P. Wu, Y. M. Zhang, J. Agarwal, E. Mathieu, S. Thorimbert, L. Dechoux. Studies towards the total synthesis of secoiridoids Gentiopicroside. Tetrahedron. 2015, 71, 7663-7669. （IF：2.39）

1. B. X. Xu, L.Unione, J.Sardinha, S. P. Wu, A. P.Rauter, Y.Blériot, Y. M.Zhang. Gem-difluoro-carbadisaccharides: restoring the exo-anomeric effect. Angew. Chem. Int. Ed. 2014, 53, 9597-9602.（IF：11.34, Top期刊）

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办公室电话 : a3a493cdbc6a35c19f092d9293f1b8fe9f50ce91930d606308565443808c162e519dd1097b4f74f82f4dcc340f6b044c86952ddd83e38e6cabfd4c46049231b886322e7345ac1b243e351b6594a00ae6925140ecc4c9fedf18a548eb5970cc3b591f167a4d0eff3f5583009ed012d9f42a713b11d4efa91d602ddb722c47aad2

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[1] 2011.11 -- 2015.7
法国巴黎第六大学       药物化学       博士研究生毕业       理学博士学位       全日制教育

[2] 2001.9 -- 2004.7
西北大学       分析化学       硕士研究生毕业       理学硕士学位       全日制教育

[3] 1995.9 -- 1999.7
西北大学       分析化学       大学本科毕业       理学学士学位       全日制教育

[1] 2015.9 -- 至今
西北大学      生命科学学院

[2] 2004.7 -- 2011.11
陕西省食品药品检验所

[1] 国际期刊Acta Materia Medica青年编委

[2] 《中国药业》杂志第九届编辑委员会编委

[3] 第三届陕西省侨联青年委员会委员

[4] 中国药学会会员

[5] 中国化学会会员