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影响因子：4.6

发表刊物：Frontiers in Endocrinology

摘要：Background: This study evaluated NMR-derived GlycA and lipoprotein subfractions for stratifying type 2 diabetes (T2DM) complication risk. Methods: A retrospective cross-sectional study included 228 adults with T2DM from two hospitals between January and December 2023. Clinical variables, the NMR-derived inflammatory markers GlycA and GlycB, and lipoprotein subfractions were analyzed. A stepwise logistic model was assessed by ROC analysis, Hosmer–Lemeshow test, bootstrap calibration, and decisioncurve analysis. Results: Age, diabetes duration, fasting plasma glucose, GlycA, and HDL1-TC were retained. The model showed good fit (c² = 7.141, P = 0.521), discrimination (AUC = 0.82, 95% CI: 0.756–0.873), calibration (MAE = 0.021), and higher net benefit than HbA1c/hs-CRP. Conclusions: A model integrating GlycA, HDL1-TC, and clinical factors showed good performance for T2DM complication risk stratification, but causal inferenceand temporal prediction cannot be established because of the crosssectional design.

论文类型：期刊论文

期号：17

页面范围：1814397

是否译文：否

收录刊物：SCI