个人简介
现为西北大学生命科学学院教授（三级）、博士生导师、硕士生导师。入选陕西省青年千人计划、西安市高层次人才。博士毕业Université de Fribourg（瑞士）基础医学生理学专业，随后在该校担任助理研究员。长期从事衰老与肥胖引起的心血管疾病及糖尿病在细胞与分子生物学层面的发病机制研究。曾获弗里堡大学最佳博士论文奖、欧洲动脉粥硬化协会青年研究人员奖，多次受邀在国际学术会议做口头报告。截至目前，以第一作者或通讯作者在 Autophagy、Redox Biology、Theranostics、Cell Death & Disease、Genes & Diseases、Journal of Advanced Research、Materials Today Bio、International Journal of Biological Macromolecules、Free Radical Biology And Medicine、Diabetes、Obesity Reviews等期刊发表SCI论文50余篇，专利授权1项。主持或参与国家级、省部级课题及横向课题10项。曾多次获得西北大学优秀硕士和博士论文指导教师，目前已指导30余名硕士和博士研究生顺利毕业，指导的硕博研究生多次获得国家奖学金。
研究领域
（1）衰老与肥胖相关心血管疾病的分子机制研究
（2）糖尿病及其并发症的细胞与分子机制研究
（3）肿瘤发生与发展的分子机制研究
（4）环境污染物暴露相关疾病的生物信息学分析及发病机制研究
（5）高原缺氧相关心血管疾病的发病机制研究
科研项目
（1）国家自然科学基金面上项目，主持
（2）陕西省高层次人才计划项目，“千人计划”青年项目，主持
（3）西藏科技厅重点研发与转化项目，主持
（4）云南省科技厅社会发展专项子课题，主持
（5）陕西省自然科学基础研究计划面上项目，主持
（6）陕西稻田诊合医疗科技有限公司—横向合作，主持
代表性论文
2026
[1] Jinli Li, Yuyan Xiong*, et al. ARG2 drives osteoblast senescence by repressing mitophagy via the IκB–NF-κB–TXN2 signaling axis: implications for age-associated osteoporosis. Theranostics. 2026; 16(16): 9295-9321 (一区TOP期刊，IF: 14.9，*通讯作者)
[2] Zhen Wang, Yuyan Xiong*, et al. A novel adenoma–carcinoma sequence– and disulfidptosis-associated gene signature for prognostic prediction and mechanistic insights in colorectal cancer. Genes & Diseases. 2026; 102269 (一区TOP期刊，IF: 14.6，*通讯作者)
[3] Yuanyuan Ren, Yuyan Xiong*, et al. ALDH3A2 negatively orchestrates gastric cancer progression through a synergistic induction of ferroptosis and ferroptosis-driven macrophage reprogramming. Cell Death & Disease. 2026; 17(1): 97 (一区TOP期刊，IF: 12.2，*通讯作者)
[4] Runlin Gui, Yuyan Xiong*, et al. Ethanolamine phosphate phospholyase drives non-alcoholic fatty liver disease via hepatocyte ferroptosis and ferroptosis-mediated macrophage reprogramming. International Journal of Biological Macromolecules. 2026; 357 (二区TOP期刊，IF: 8.7，*通讯作者)
[5] Yafang Yang, Yuyan Xiong*, et al. Tiny genome with big impact: mitochondrial DNA in cardiovascular health. Journal of Genetics and Genomics. 2026; 53(5): 767-783 (一区期刊，IF: 7.9，*通讯作者)
[6] Yang Li, Yuyan Xiong*, et al. Integrative epidemiological and experimental evidence implicates CCNA2-associated macrophage–hepatocyte crosstalk in dimethyl phosphate exposure-associated NAFLD. Environmental Pollution. 2026; 405:128473. (二区期刊，IF: 7.2，*通讯作者)
[7] Fanglin Niu, Yuyan Xiong*, et al. RNA-binding protein GIGYF2 promotes colorectal cancer progression through activation of the METTL3/SERP1/STAT3 axis in an m6A-IGF2BP2-dependent manner. Biochemical Pharmacology. 2026; 243(Pt 1): 117446 (二区TOP期刊，IF: 6.5，*通讯作者)
[8] Rui Liang, Yuyan Xiong*, et al. Hydrogen sulfide revisited: a stealthy ally in the unseen war against cardiovascular disease. Biochemical Pharmacology. 2026; 244: 117577 (二区TOP期刊，IF: 6.5，*通讯作者)
[9] Jiaoyu Li, Yuyan Xiong*, et al. The Yin and Yang of copper in cardiovascular health and disease. Molecular And Cellular Biochemistry. 2026; 481(1):81-107. (二区期刊，IF: 4.7，*通讯作者)
2025
[1] Diduo Bai, Yuyan Xiong*, et al. Ferroptosis: a novel therapeutic warrior in the battle against leukemia. Apoptosis. 2025; 30(7-8):1776-1795. (一区TOP期刊，IF: 9.0，*通讯作者)
[2] Wenxuan Liu, Yuyan Xiong*, et al. Linarin Identified as a Bioactive Compound of Lycii Cortex Ameliorates Insulin Resistance and Inflammation Through the c-FOS/ARG2 Signaling Axis. Phytotherapy Research. 2025; 39(1): 246-263 (二区TOP期刊，IF: 8.1，*通讯作者)
[3] Yuanyuan Ren, Yuyan Xiong*, et al. Integrative bioinformatics and experimental validation unveil CRISP3 as a hypoxia-, epithelial mesenchymal transition-, and immune-related prognostic biomarker and therapeutic target in breast cancer. Frontiers in Immunology. 2025; 22:16:1634399. (二区期刊，IF: 7.0，*通讯作者)
[4] Silong Yang, Yuyan Xiong*, et al. RNA-binding protein GIGYF2 promotes colorectal cancer progression through activation of the METTL3/SERP1/STAT3 axis in an m6A-IGF2BP2-dependent manner. International Journal of Biological Macromolecules. 2025; 329:147826. (二区期刊，IF: 8.7，*通讯作者)
[5] Jinli Li, Yuyan Xiong*, et al. Revolutionizing cardiovascular research: Human organoids as a Beacon of hope for understanding and treating cardiovascular diseases. Materials Today Bio. 2025; 30: 101396. (一区TOP期刊，IF: 11.0，*通讯作者)
[6] Yan Zhang, Yuyan Xiong*, et al. Exosomal SLC1A5 from senescent endothelial cells promotes gastric cancer progression by dampening ferroptosis via the EGFR/SRC/YAP1/GPX4 signaling. Free Radical Biology and Medicine. 2025; 235: 25-42 (一区TOP期刊，IF: 8.0，*通讯作者)
[7] Chengsong Wu, Yuyan Xiong*, et al. Identification and Experimental Validation of NETosis-Mediated Abdominal Aortic Aneurysm Gene Signature Using Multi-omics, Machine Learning, and Mendelian Randomization. Journal of Chemical Information and Modeling. 2025; 65(7): 3771-3788 (二区TOP期刊，IF: 6.4，*通讯作者)
[8] Yuyan Xiong，et al. MOTS-c及其氨基酸突变多肽在伤口愈合方面的用途，已授权 （专利号：ZL202411395797.X）
2024
[1] Yang Li, Yuyan Xiong*, et al. Mitochondrial-derived peptides in cardiovascular disease: Novel insights and therapeutic opportunities. Journal of Advanced Research. 2024; 64: 99-115 (二区TOP期刊，IF: 17.1，*通讯作者)
[2] Fanglin Niu, Yuyan Xiong*, et al. β-cell neogenesis: A rising star to rescue diabetes mellitus. Journal of Advanced Research. 2024: 62: 71–89. (二区TOP期刊，IF: 17.1，*通讯作者)
[3] Yan Zhang, Yuyan Xiong*, et al. A review on decoding the roles of YAP/TAZ signaling pathway in cardiovascular diseases: Bridging molecular mechanisms to therapeutic insights. International Journal of Biological Macromolecules. 2024; 271:132473. (二区期刊，IF: 8.7，*通讯作者)
[4] Runlin, Gui, Yuyan Xiong*, et al. Deciphering interleukin-18 in diabetes and its complications: Biological features, mechanisms, and therapeutic perspectives. Obesity Reviews. 2024;25(11):e13818. (二区期刊，IF: 7.6，*通讯作者)
[5] Ziwei Lv, Yuyan Xiong*, et al. RNA-binding protein GIGYF2 orchestrates hepatic insulin resistance through STAU1/PTEN-mediated disruption of the PI3K/AKT signaling cascade. Molecular Medicine. 2024; 30(1): 124 (二区TOP期刊，IF: 8.3，*通讯作者)
[6] Yirong Li, Yuyan Xiong*, et al. Development and validation of a hypoxia- and mitochondrial dysfunction-related prognostic model based on integrated single-cell and bulk RNA sequencing analyses in gastric cancer. Frontiers in Immunology. 2024; 15: 1419133 (二区期刊，IF: 7.0，*通讯作者)
[7] Jiangxia Wang, Yuyan Xiong*, et al. SFRP4 contributes to insulin resistance-induced polycystic ovary syndrome by triggering ovarian granulosa cell hyperandrogenism and apoptosis through the nuclear β-catenin/IL-6 signaling axis. Biochimica et Biophysica Acta-Molecular Cell Research. 2024; 1871(7): 119822 (二区期刊，IF: 4.3，*通讯作者)
2023
[1] Fanglin Niu, Yuyan Xiong*, et al. Aberrant hyper-expression of the RNA binding protein GIGYF2 in endothelial cells modulates vascular aging and function. Redox Biology. 2023; 65: 102824 (一区TOP期刊，IF: 16.2，*通讯作者)
[2] Caihua Wang, Yuyan Xiong*, et al. ETNPPL impairs autophagy through regulation of the ARG2-ROS signaling axis, contributing to palmitic acid-induced hepatic insulin resistance. Free Radical Biology and Medicine. 2023; 199: 126-140 (一区TOP期刊，IF: 8.0，*通讯作者)
[3] Yuanyuan Ren, Yuyan Xiong*, et al. m6A mRNA methylation: Biological features, mechanisms, and therapeutic potentials in type 2 diabetes mellitus. Obesity Reviews. 2023; 24(12):e13639. (二区期刊，IF: 7.6，*通讯作者)
[4] Qiang Ye, Yuyan Xiong*, et al. Exosome-derived microRNA: implications in melanoma progression, diagnosis and treatment. Cancers. 2023, 15, 80. (二区期刊，IF: 4.8，*通讯作者)
[5] Yajun Wang, Yuyan Xiong*, et al. The lncRNA OIP5-AS1/miR-4500 axis targeting ARG2 modulates oxidative stress-induced premature senescence in endothelial cells: implications for vascular aging. Expert Opinion on Therapeutic Targets. 2023; 27(4-5): 393-407 (二区期刊，IF: 5.3，*通讯作者)
[6] Chen X, Yuyan Xiong*, et al. ETNPPL modulates hyperinsulinemia-induced insulin resistance through the SIK1/ROS-mediated inactivation of the PI3K/AKT signaling pathway in hepatocytes. Journal of Cellular Physiology. 2023; 238(5): 1046-1062 (二区期刊，IF: 4.0，*通讯作者)
[7] Yuan Wang, Yuyan Xiong*, et al. Correlation between ESR1 and APOE gene polymorphisms and risk of osteonecrosis of the femoral head: a case–control study. Journal of Orthopaedic Surgery and Research. 2023; 18:968. (三区期刊，IF: 3.8，*通讯作者)
[8] Liwei Wang, Yuyan Xiong*, et al. Identification of a novel gene signature combining ferroptosis- and immunity-related genes for prognostic prediction, immunotherapy and potential therapeutic targets in gastric cancer. Journal of Cancer. 2023; 14(18): 3457-3476. (三区期刊，IF: 3.4，*通讯作者)
2022
[1] Yi Yu, Yuyan Xiong*, et al. Arginase 2 negatively regulates sorafenib-induced cell death through mediating ferroptosis in melanoma. Acta Biochimica et Biophysica Sinica. 2022, 25;54(11):1658-1670. (*通讯作者)
[2] Fangling Niu, Yuyan Xiong*, et al. Arginase: An emerging and promising therapeutic target for cancer treatment. Biomedicine & Pharmacotherapy. 2022.149:112840. (*通讯作者)
[3] Yuanyuan Ren, Yuyan Xiong*, et al. Arginase: Biological and Therapeutic Implications in Diabetes Mellitus and Its Complications. 2022. Oxidative Medicine And Cellular Longevity. 2022. 26:2022:2419412. (*通讯作者)
[4] Zhuozhuo Li, Arginase: shedding light on the mechanisms and opportunities in cardiovascular diseases. Cell Death Discovery. 2022. 8;8(1):413. (中科院一区，IF: 10.4，*通讯作者)
Before 2022
[1] Yuyan Xiong*, et al. Ferroptosis: a cell death connecting oxidative stress, inflammation and cardiovascular diseases. Cell Death Discovery. 2021, 7:193. (中科院一区，IF: 10.4，*通讯作者)
[2] Yi Yu#, Yuyan Xiong*, et al. Myosin-1b mediates effects of arginase-II on mTORC1 activation through promoting lysosomal positioning and dissociation from TSC. Cell Death and Disease. 2018; 9:313 (一区，共同第一作者, IF: 12.2)
[3] Yuyan Xiong, et al. Arginase-II Promotes Tumor Necrosis Factor-a Release From Pancreatic Acinar Cells Causing b-Cell Apoptosis in Aging. Diabetes. 2017, 66:1636–1649.（IF: 9.3，第一作者）
[4] Yuyan Xiong, et al. Arginase-II impairs endothelial autophagy through regulation of mTOR and AMPK signaling in advanced atherosclerosis. Autophagy. 2014, 10(12): 2223-38. （中科院一区 TOP期刊，IF: 18.6，第一作者）
[5] Yuyan Xiong, et al. Arginase-II Induces Vascular Smooth Muscle Cell Senescence and Apoptosis Through p66Shc and p53 Independently of Its L-Arginine Ureahydrolase Activity: Implications for Atherosclerotic Plaque Vulnerability. Journal of the American Heart Association. 2013, 5; 2(4): e000096. （第一作者）
[6] Yuyan Xiong, et al. Arginase-II regulates mouse life span. Frontiers in Physiology. 2017; 8: 682
[7] Huang J, Rajapakse A, Yuyan Xiong, et al. Genetic Targeting of Arginase-II in Mouse Prevents Renal Oxidative Stress and Inflammation in Diet-Induced Obesity. Frontiers in Physiology. 2016, 7:560. doi: 10.3389/fphys.2016.00560
[8] Yu Y, Xiong Y, et al. En Face Detection of Nitric Oxide and Superoxide in Endothelial Layer of Intact Arteries. J Vis Exp. 2016 Feb 25;(108):53718. （四区）
[9] Wu Z, Yu Y, Liu C, Xiong Y, Montani JP, Yang Z, Ming X-F. Role of p38 mitogen-activated protein kinase in vascular endothelial aging: Interaction with Arginase-II and S6K1 signaling pathway. Aging-US. 2015;7(1):70-81.
[10] Yuyan Xiong, et al. Long term exposure to L-arginine accelerates endothelial cell senescence through arginase-II and S6K1 signaling. Aging-US. 2014, 6(5): 369-379.
[11] Yepuri G#, Velagapudi S#, Xiong Y, Rajapakse AG, Montani JP, Ming XF, Yang Z. Positive crosstalk between arginase-II and S6K1 in vascular endothelial inflammation and aging. Aging Cell. 2012, 11(6):1005-16. （一区, #共同第一作者）
[12] Ming X-F, Rajapakse AG, Yepuri G, Xiong Y, Carvas JM, Ruffieux J, Scerri I, Wu Z, Popp K, Li J, Sartori C, Scherrer U, Kwak BR, Montani J-P, Yang Z. Arginase-II promotes macrophage inflammatory responses through mitochondrial reactive oxygen species, contributing to insulin resistance and atherogenesis. Journal of the American Heart Association. 2012; 1: e000992doi:10.1161/JAHA.112.000992. （二区）
[13] Yuyan Xiong, et al. Production and characterization of a novel bioflocculant from Bacillus licheniformis. Applied and Environmental Microbiology. 2010, 76(9): 2778–2782.