Personal Information

Biography

Prof. Dr. Yuyan Xiong, is currently a Professor (Level III), PhD Supervisor, and Master’s Supervisor at the College of Life Sciences, Northwest University. I have been selected for the Shaanxi Province Young Thousand Talents Program and recognized as a High-Level Talent of Xi’an.

I received my PhD in Physiology from the Department of Medicine, University of Fribourg, Switzerland, where I subsequently worked as an Assistant Researcher. My research has long focused on elucidating the cellular and molecular mechanisms underlying cardiovascular diseases and diabetes associated with aging and obesity.

I have received several academic honors, including the Best Doctoral Thesis Award from the University of Fribourg and the Young Investigator Award from the European Atherosclerosis Society, and have been invited to deliver oral presentations at international academic conferences on multiple occasions.

To date, I have published more than 50 SCI-indexed papers as a first or corresponding author in leading international journals, including Autophagy, Redox Biology, Theranostics, Cell Death & Disease, Genes & Diseases, Materials Today Bio, International Journal of Biological Macromolecules, Free Radical Biology and Medicine, Diabetes, Obesity Reviews, and Journal of Advanced Research. I have also served as principal investigator or participant in 10 national, provincial, and ministerial-level research projects.

I have received the Outstanding Master’s and Doctoral Thesis Supervisor Award from Northwest University on multiple occasions. To date, I have supervised more than 30 master’s and doctoral students to successful completion of their degrees, and many of my students have received National Scholarships.

Contact: yuyan.xiong@nwu.edu.cn

Research Interests

1. Molecular mechanisms of aging- and obesity-related cardiovascular diseases

2. Cellular and molecular mechanisms of diabetes and its complications

3. Molecular mechanisms underlying tumor initiation and progression

4. Bioinformatics analysis and pathogenic mechanisms of diseases associated with environmental pollutant exposure

5. Pathogenic mechanisms of cardiovascular diseases associated with high-altitude hypoxia

Research Projects

1. General Program of the National Natural Science Foundation of China (NSFC) — Principal Investigator

2. Shaanxi Province High-Level Talent Program, Young Thousand Talents Program — Principal Investigator

3. Key Research, Development and Transformation Program of the Department of Science and Technology of the Tibet Autonomous Region — Principal Investigator

4. Social Development Program of the Yunnan Provincial Department of Science and Technology (Subproject) — Principal Investigator

5. General Program of the Natural Science Basic Research Program of Shaanxi Province — Principal Investigator

 

Selected Publications

2026

[1] Jinli Li, Yuyan Xiong*, et al. ARG2 drives osteoblast senescence by repressing mitophagy via the IκB–NF-κB–TXN2 signaling axis: implications for age-associated osteoporosis. Theranostics. 2026; 16(16): 9295-9321 (一区TOP期刊，IF: 14.9，*corresponding author)

[2] Zhen Wang, Yuyan Xiong*, et al. A novel adenoma–carcinoma sequence– and disulfidptosis-associated gene signature for prognostic prediction and mechanistic insights in colorectal cancer. Genes & Diseases. 2026; 102269 (一区TOP期刊，IF: 14.6，*corresponding author)

[3] Yuanyuan Ren, Yuyan Xiong*, et al. ALDH3A2 negatively orchestrates gastric cancer progression through a synergistic induction of ferroptosis and ferroptosis-driven macrophage reprogramming. Cell Death & Disease. 2026; 17(1): 97 (一区TOP期刊，IF: 12.2，*corresponding author)

[4] Runlin Gui, Yuyan Xiong*, et al. Ethanolamine phosphate phospholyase drives non-alcoholic fatty liver disease via hepatocyte ferroptosis and ferroptosis-mediated macrophage reprogramming. International Journal of Biological Macromolecules. 2026; 357 (二区TOP期刊，IF: 8.7，*corresponding author)

[5] Yafang Yang, Yuyan Xiong*, et al. Tiny genome with big impact: mitochondrial DNA in cardiovascular health. Journal of Genetics and Genomics. 2026; 53(5): 767-783 (一区期刊，IF: 7.9，*corresponding author)

[6] Yang Li, Yuyan Xiong*, et al. Integrative epidemiological and experimental evidence implicates CCNA2-associated macrophage–hepatocyte crosstalk in dimethyl phosphate exposure-associated NAFLD. Environmental Pollution. 2026; 405:128473. (二区期刊，IF: 7.2，*corresponding author)

[7] Fanglin Niu, Yuyan Xiong*, et al. RNA-binding protein GIGYF2 promotes colorectal cancer progression through activation of the METTL3/SERP1/STAT3 axis in an m6A-IGF2BP2-dependent manner. Biochemical Pharmacology. 2026; 243(Pt 1): 117446 (二区TOP期刊，IF: 6.5，*corresponding author)

[8] Rui Liang, Yuyan Xiong*, et al. Hydrogen sulfide revisited: a stealthy ally in the unseen war against cardiovascular disease. Biochemical Pharmacology. 2026; 244: 117577 (二区TOP期刊，IF: 6.5，*corresponding author)

[9] Jiaoyu Li, Yuyan Xiong*, et al. The Yin and Yang of copper in cardiovascular health and disease. Molecular And Cellular Biochemistry. 2026; 481(1):81-107. (二区期刊，IF: 4.7，*corresponding author)

2025

[1] Diduo Bai, Yuyan Xiong*, et al. Ferroptosis: a novel therapeutic warrior in the battle against leukemia. Apoptosis. 2025; 30(7-8):1776-1795. (一区TOP期刊，IF: 9.0，*corresponding author)

[2] Wenxuan Liu, Yuyan Xiong*, et al. Linarin Identified as a Bioactive Compound of Lycii Cortex Ameliorates Insulin Resistance and Inflammation Through the c-FOS/ARG2 Signaling Axis. Phytotherapy Research. 2025; 39(1): 246-263 (二区TOP期刊，IF: 8.1，*corresponding author)

[3] Yuanyuan Ren, Yuyan Xiong*, et al. Integrative bioinformatics and experimental validation unveil CRISP3 as a hypoxia-, epithelial mesenchymal transition-, and immune-related prognostic biomarker and therapeutic target in breast cancer. Frontiers in Immunology. 2025; 22:16:1634399. (二区期刊，IF: 7.0，*corresponding author)

[4] Silong Yang, Yuyan Xiong*, et al. RNA-binding protein GIGYF2 promotes colorectal cancer progression through activation of the METTL3/SERP1/STAT3 axis in an m6A-IGF2BP2-dependent manner. International Journal of Biological Macromolecules. 2025; 329:147826. (二区期刊，IF: 8.7，*corresponding author)

[5] Jinli Li, Yuyan Xiong*, et al.  Revolutionizing cardiovascular research: Human organoids as a Beacon of hope for understanding and treating cardiovascular diseases. Materials Today Bio. 2025; 30: 101396. (一区TOP期刊，IF: 11.0，*corresponding author)

[6] Yan Zhang, Yuyan Xiong*, et al. Exosomal SLC1A5 from senescent endothelial cells promotes gastric cancer progression by dampening ferroptosis via the EGFR/SRC/YAP1/GPX4 signaling. Free Radical Biology and Medicine. 2025; 235: 25-42 (一区TOP期刊，IF: 8.0，*corresponding author)

[7] Chengsong Wu, Yuyan Xiong*, et al. Identification and Experimental Validation of NETosis-Mediated Abdominal Aortic Aneurysm Gene Signature Using Multi-omics, Machine Learning, and Mendelian Randomization. Journal of Chemical Information and Modeling. 2025; 65(7): 3771-3788 (二区TOP期刊，IF: 6.4，*corresponding author)

2024

[1] Yang Li, Yuyan Xiong*, et al. Mitochondrial-derived peptides in cardiovascular disease: Novel insights and therapeutic opportunities. Journal of Advanced Research. 2024; 64: 99-115 (二区TOP期刊，IF: 17.1，*corresponding author)

[2] Fanglin Niu, Yuyan Xiong*, et al. β-cell neogenesis: A rising star to rescue diabetes mellitus. Journal of Advanced Research. 2024: 62: 71–89.  (二区TOP期刊，IF: 17.1，*corresponding author)

[3] Yan Zhang, Yuyan Xiong*, et al. A review on decoding the roles of YAP/TAZ signaling pathway in cardiovascular diseases: Bridging molecular mechanisms to therapeutic insights. International Journal of Biological Macromolecules. 2024; 271:132473. (二区期刊，IF: 8.7，*corresponding author)

[4] Runlin, Gui, Yuyan Xiong*, et al. Deciphering interleukin-18 in diabetes and its complications: Biological features, mechanisms, and therapeutic perspectives. Obesity Reviews. 2024;25(11):e13818.  (二区期刊，IF: 7.6，*corresponding author)

[5] Ziwei Lv, Yuyan Xiong*, et al. RNA-binding protein GIGYF2 orchestrates hepatic insulin resistance through STAU1/PTEN-mediated disruption of the PI3K/AKT signaling cascade. Molecular Medicine. 2024; 30(1): 124 (二区TOP期刊，IF: 8.3，*corresponding author)

[6] Yirong Li, Yuyan Xiong*, et al. Development and validation of a hypoxia- and mitochondrial dysfunction-related prognostic model based on integrated single-cell and bulk RNA sequencing analyses in gastric cancer. Frontiers in Immunology. 2024; 15: 1419133 (二区期刊，IF: 7.0，*corresponding author)

[7] Jiangxia Wang, Yuyan Xiong*, et al. SFRP4 contributes to insulin resistance-induced polycystic ovary syndrome by triggering ovarian granulosa cell hyperandrogenism and apoptosis through the nuclear β-catenin/IL-6 signaling axis. Biochimica et Biophysica Acta-Molecular Cell Research. 2024; 1871(7): 119822 (二区期刊，IF: 4.3，*corresponding author)

2023

[1] Fanglin Niu, Yuyan Xiong*, et al. Aberrant hyper-expression of the RNA binding protein GIGYF2 in endothelial cells modulates vascular aging and function. Redox Biology. 2023; 65: 102824 (一区TOP期刊，IF: 16.2，*corresponding author)

[2] Caihua Wang, Yuyan Xiong*, et al. ETNPPL impairs autophagy through regulation of the ARG2-ROS signaling axis, contributing to palmitic acid-induced hepatic insulin resistance. Free Radical Biology and Medicine. 2023; 199: 126-140 (一区TOP期刊，IF: 8.0，*corresponding author)

[3] Yuanyuan Ren, Yuyan Xiong*, et al. m6A mRNA methylation: Biological features, mechanisms, and therapeutic potentials in type 2 diabetes mellitus. Obesity Reviews. 2023; 24(12):e13639.  (二区期刊，IF: 7.6，*corresponding author)

[4] Qiang Ye, Yuyan Xiong*, et al. Exosome-derived microRNA: implications in melanoma progression, diagnosis and treatment. Cancers. 2023, 15, 80. (二区期刊，IF: 4.8，*corresponding author)

[5] Yajun Wang, Yuyan Xiong*, et al. The lncRNA OIP5-AS1/miR-4500 axis targeting ARG2 modulates oxidative stress-induced premature senescence in endothelial cells: implications for vascular aging. Expert Opinion on Therapeutic Targets. 2023; 27(4-5): 393-407 (二区期刊，IF: 5.3，*corresponding author)

[6] Chen X, Yuyan Xiong*, et al. ETNPPL modulates hyperinsulinemia-induced insulin resistance through the SIK1/ROS-mediated inactivation of the PI3K/AKT signaling pathway in hepatocytes. Journal of Cellular Physiology. 2023; 238(5): 1046-1062 (二区期刊，IF: 4.0，*corresponding author)

[7] Yuan Wang, Yuyan Xiong*, et al. Correlation between ESR1 and APOE gene polymorphisms and risk of osteonecrosis of the femoral head: a case–control study. Journal of Orthopaedic Surgery and Research. 2023; 18:968. (三区期刊，IF: 3.8，*corresponding author)

[8] Liwei Wang, Yuyan Xiong*, et al. Identification of a novel gene signature combining ferroptosis- and immunity-related genes for prognostic prediction, immunotherapy and potential therapeutic targets in gastric cancer. Journal of Cancer. 2023; 14(18): 3457-3476. (三区期刊，IF: 3.4，*corresponding author)

2022

[1] Yi Yu, Yuyan Xiong*, et al. Arginase 2 negatively regulates sorafenib-induced cell death through mediating ferroptosis in melanoma. Acta Biochimica et Biophysica Sinica. 2022, 25;54(11):1658-1670. (*corresponding author)

[2] Fangling Niu, Yuyan Xiong*, et al. Arginase: An emerging and promising therapeutic target for cancer treatment. Biomedicine & Pharmacotherapy. 2022.149:112840. (*corresponding author)

[3] Yuanyuan Ren, Yuyan Xiong*, et al. Arginase: Biological and Therapeutic Implications in Diabetes Mellitus and Its Complications. 2022. Oxidative Medicine And Cellular Longevity. 2022. 26:2022:2419412. (*corresponding author)

[4] Zhuozhuo Li, Arginase: shedding light on the mechanisms and opportunities in cardiovascular diseases. Cell Death Discovery. 2022. 8;8(1):413. (中科院一区，IF: 10.4，*corresponding author)

Before 2022

[1] Yuyan Xiong*, et al. Ferroptosis: a cell death connecting oxidative stress, inflammation and cardiovascular diseases. Cell Death Discovery. 2021, 7:193. (中科院一区，IF: 10.4，*corresponding author)

[2] Yi Yu#, Yuyan Xiong*, et al. Myosin-1b mediates effects of arginase-II on mTORC1 activation through promoting lysosomal positioning and dissociation from TSC. Cell Death and Disease. 2018; 9:313 (一区，共同第一作者, IF: 12.2)

[3] Yuyan Xiong, et al. Arginase-II Promotes Tumor Necrosis Factor-a Release From Pancreatic Acinar Cells Causing b-Cell Apoptosis in Aging. Diabetes. 2017, 66:1636–1649.（IF: 9.3，第一作者）

[4] Yuyan Xiong, et al.  Arginase-II impairs endothelial autophagy through regulation of mTOR and AMPK signaling in advanced atherosclerosis. Autophagy. 2014, 10(12): 2223-38. （中科院一区 TOP期刊，IF: 18.6，第一作者）

[5] Yuyan Xiong, et al. Arginase-II Induces Vascular Smooth Muscle Cell Senescence and Apoptosis Through p66Shc and p53 Independently of Its L-Arginine Ureahydrolase Activity: Implications for Atherosclerotic Plaque Vulnerability. Journal of the American Heart Association. 2013, 5; 2(4): e000096. （第一作者）

[6] Yuyan Xiong, et al. Arginase-II regulates mouse life span. Frontiers in Physiology. 2017; 8: 682

[7] Huang J, Rajapakse A, Yuyan Xiong, et al. Genetic Targeting of Arginase-II in Mouse Prevents Renal Oxidative Stress and Inflammation in Diet-Induced Obesity. Frontiers in Physiology. 2016, 7:560. doi: 10.3389/fphys.2016.00560

[8] Yu Y, Xiong Y, et al. En Face Detection of Nitric Oxide and Superoxide in Endothelial Layer of Intact Arteries. J Vis Exp. 2016 Feb 25;(108):53718. （四区）

[9] Wu Z, Yu Y, Liu C, Xiong Y, Montani JP, Yang Z, Ming X-F. Role of p38 mitogen-activated protein kinase in vascular endothelial aging: Interaction with Arginase-II and S6K1 signaling pathway. Aging-US. 2015;7(1):70-81.

[10] Yuyan Xiong, et al. Long term exposure to L-arginine accelerates endothelial cell senescence through arginase-II and S6K1 signaling. Aging-US. 2014, 6(5): 369-379.

[11] Yepuri G#, Velagapudi S#, Xiong Y, Rajapakse AG, Montani JP, Ming XF, Yang Z. Positive crosstalk between arginase-II and S6K1 in vascular endothelial inflammation and aging. Aging Cell. 2012, 11(6):1005-16. （一区, #共同第一作者）

[12] Ming X-F, Rajapakse AG, Yepuri G, Xiong Y, Carvas JM, Ruffieux J, Scerri I, Wu Z, Popp K, Li J, Sartori C, Scherrer U, Kwak BR, Montani J-P, Yang Z. Arginase-II promotes macrophage inflammatory responses through mitochondrial reactive oxygen species, contributing to insulin resistance and atherogenesis. Journal of the American Heart Association. 2012; 1: e000992doi:10.1161/JAHA.112.000992. （二区）

[13] Yuyan Xiong,  et al. Production and characterization of a novel bioflocculant from Bacillus licheniformis. Applied and Environmental Microbiology. 2010, 76(9): 2778–2782.