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熊裕焱，现为西北大学生命科学学院教授、博士生导师、硕士生导师。入选陕西省青年千人计划、西安市高层次人才。2014年获得瑞士弗里堡大学生理学专业博士学位，随后在该校担任助理研究员至2019年。长期从事衰老与肥胖引起的心血管疾病及糖尿病在细胞与分子生物学层面的发病机制研究。曾获弗里堡大学最佳博士论文奖、欧洲动脉粥硬化协会青年研究人员奖，多次受邀在国际学术会议做口头报告。截至目前，以第一作者或通讯作者在 Redox Biology、Autophagy、Diabetes、Obesity Reviews、Journal of Advanced Research 等高水平期刊发表SCI论文50余篇，主持或参与国家级、省部级课题10项。

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研究领域

·       衰老与肥胖相关心血管疾病的分子机制

·       糖尿病及其并发症的细胞信号通路

·       内皮细胞功能障碍与血管老化

·       线粒体功能、自噬与铁死亡在代谢疾病中的作用

·       高原相关心血管疾病的发病机制研究

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科研项目

·       国家自然科学基金面上项目，WDR76通过铁死亡-铁死亡旁分泌效应-细胞衰老轴介导内皮功能障碍在肥胖相关血管老化与动脉粥样硬化中的作用机制研究，49万，2025-2028，主持

·       西藏科技厅重点研发与转化项目，长期高海拔环境对血管老化影响机制及藏药干预策略研究，135万，2025-2027，主持

·       云南省科技厅社会发展专项子课题，中医补虚化瘀通络执法逆转心血管栓塞性疾病的关键技术开发及应用，45万，2024-2026，主持

·       陕西省自然科学基础研究计划面上项目，GIGYF2通过mTORC1-S6K1信号通路介导细胞衰老，5万，2023，主持

·       陕西省高层次人才计划项目，“千人计划”青年项目，80万，2020，主持

·       西北大学科技处防治新冠肺炎基金科研专项引导基金，新型冠状病毒（2019-nCoV）肺炎早期快速筛查试纸的开发，10万，2020，主持

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代表性论文

[1]   Zhen Wang, Yuyan Xiong(熊裕焱)*, et al. A novel adenoma–carcinoma sequence– and disulfidptosis-associated gene signature for prognostic prediction and mechanistic insights in colorectal cancer.Genes & Diseases. Accepted (一区TOP期刊，IF: 9.4，*通讯作者)

[2]  Runlin Gui, Yuyan Xiong(熊裕焱)*, et al. Ethanolamine phosphate phospholyase drives non-alcoholic fatty liver disease via hepatocyte ferroptosis and ferroptosis-mediated macrophage reprogramming.International Journal of Biological Macromolecules. Volume 357, April 2026.(二区TOP期刊，IF: 8.5，*通讯作者)

[3]  Fanglin Niu, Yuyan Xiong(熊裕焱)*, et al. RNA-binding protein GIGYF2 promotes colorectal cancer progression through activation of the METTL3/SERP1/STAT3 axis in an m6A-IGF2BP2-dependent manner. Biochemical pharmacology. 2026 Jan;243(Pt 1):117446. (二区TOP期刊，IF: 5.6，*通讯作者)

[4] Yuanyuan Ren, Yuyan Xiong(熊裕焱)*, et al. ALDH3A2 negatively orchestrates gastric cancer progression through a synergistic induction of ferroptosis and ferroptosis-driven macrophage reprogramming. Cell Death & Disease. 2026;17(1):97. (一区TOP期刊，IF: 9.6，*通讯作者)

[5]  Rui Liang, Yuyan Xiong(熊裕焱)*, et al. Hydrogen sulfide revisited: a stealthy ally in the unseen war against cardiovascular disease. Biochemical pharmacology. 2026 Feb:244:117577. (二区TOP期刊，IF: 5.6，*通讯作者)

[6]   Yan Zhang, Yuyan Xiong(熊裕焱)*, et al. Exosomal SLC1A5 from senescent endothelial cells promotes gastric cancer progression by dampening ferroptosis via the EGFR/SRC/YAP1/ GPX4 signaling. Free Radical Biology And Medicine. 2025 Apr 19:235:25-42. (一区TOP期刊，IF: 8.2，*通讯作者)

[7]  Chengsong Wu, Yuyan Xiong(熊裕焱)*, et al. Identification and Experimental Validation of NETosis-Mediated Abdominal Aortic Aneurysm Gene Signature Using Multi-omics, Machine Learning, and Mendelian Randomization. Journal of Chemical Information And Modeling. 2025 Apr 14;65(7):3771-3788. (二区TOP期刊，IF: 5.7，*通讯作者)

[8]   Wenxuan Liu, Yuyan Xiong(熊裕焱)*, et al. Linarin Identified as a Bioactive Compound of Lycii Cortex Ameliorates Insulin Resistance and Inflammation Through the c-FOS/ARG2 Signaling Axis. Phytotherapy research. 2025;39(1):246-263. (二区TOP期刊，IF: 6.1，*通讯作者)

[9]  Jinli Li, Yuyan Xiong(熊裕焱)*, et al. Revolutionizing cardiovascular research: Human organoids as a Beacon of hope for understanding and treating cardiovascular diseases. Materials Today Bio. 2024 Dec 9:30:101396. (一区Top，IF: 10.2，*通讯作者)

[10] Ziwei Lv, Yuyan Xiong(熊裕焱)*, et al. RNA-binding protein GIGYF2 orchestrates hepatic insulin resistance through STAU1/PTEN-mediated disruption of the PI3K/AKT signaling cascade. Molecular medicine. 2024;30(1):124. (二区TOP期刊，IF: 6.4，*通讯作者)

[11] Jiangxia Wang, Yuyan Xiong(熊裕焱)*, et al. SFRP4 contributes to insulin resistance-induced polycystic ovary syndrome by triggering ovarian granulosa cell hyperandrogenism and apoptosis through the nuclear β-catenin/IL-6 signaling axis. Biochimica et Biophysica Acta-Molecular Cell Research. 2024;1871(7):119822. (三区，IF: 3.7，*通讯作者)

[12]  Yirong Li, Yuyan Xiong(熊裕焱)*, et al. Development and validation of a hypoxia- and mitochondrial dysfunction- related prognostic model based on integrated single-cell and bulk RNA sequencing analyses in gastric cancer. Frontiers in immunology. 2024;15:1419133. (二区TOP期刊，IF: 5.9，*通讯作者)

[13] Yang Li, Yuyan Xiong(熊裕焱)*, et al. Mitochondrial-derived peptides in cardiovascular disease: Novel insights and therapeutic opportunities. Journal of Advanced Research. 2024 Oct:64:99-115. (一区TOP期刊，IF: 13，*通讯作者)

[14] Fanglin Niu, Error! Filename not specified.Yuyan Xiong(熊裕焱)*, et al. Aberrant hyper-expression of the RNA binding protein GIGYF2 in endothelial cells modulates vascular aging and function. Redox Biology. 2023，65: 102824.Error! Filename not specified. (一区TOP期刊，IF: 11.9，*通讯作者)

[15] Niu F, Yuyan Xiong(熊裕焱)*, et al. β-cell neogenesis: A rising star to rescue diabetes mellitus. Journal of Advanced Research. 2023, 13:S2090-1232(23)00312-0. (一区TOP期刊，IF: 13，*通讯作者)

[16] Caihua Wang, Yuyan Xiong(熊裕焱)*, et al. ETNPPL impairs autophagy through regulation of the ARG2-ROS signaling axis, contributing to palmitic acid-induced hepatic insulin resistance. Free Radical Biology and Medicine. 2023,199: 126-140.（一区 TOP期刊，IF: 8.2，*通讯作者）

[17] Yajun Wang, Yuyan Xiong(熊裕焱)*, et al. The lncRNA OIP5-AS1/miR-4500 axis targeting ARG2 modulates oxidative stress-induced premature senescence in endothelial cells: implications for vascular aging. Expert Opinion on Therapeutic Targets. 2023, 27(4-5): 393-407. (二区，IF: 4.4，*通讯作者)

[18] Chen X, Yuyan Xiong(熊裕焱)*, et al. ETNPPL modulates hyperinsulinemia-induced insulin resistance through the SIK1/ROS-mediated inactivation of the PI3K/AKT signaling pathway in hepatocytes. Journal of cellular physiology. 2023, 238(5):1046-1062. (二区，IF: 4，*通讯作者)

[19] Yi Yu#, Yuyan Xiong(熊裕焱)#, et al. Arginase-II activates mTORC1 through myosin-1b in vascular cell senescence and apoptosis. Cell Death and Disease. 2018; 9:313 （一区TOP期刊，IF: 9.6，#共同第一作者）

[20] Yuyan Xiong (熊裕焱), et al. Arginase-II Promotes Tumor Necrosis Factor-a Release From Pancreatic Acinar Cells Causing b-Cell Apoptosis in Aging. Diabetes. 2017, 66:1636–1649.（一区 TOP期刊，IF: 7.5，第一作者）

[21] Yuyan Xiong(熊裕焱), et al. Arginase-II impairs endothelial autophagy through regulation of mTOR and AMPK signaling in advanced atherosclerosis. Autophagy. 2014, 10(12): 2223-38. （一区 TOP期刊，IF: 14.3，第一作者）