关锋：西北大学生命科学学院副院长； 陕西省生物技术与生化工程重点实验室主任； 中国生物工程学会糖生物学工程分会副主任委员；陕西省基因组与健康学会理事长； 陕西省基础科学（化学、生物学）研究院副院长； 中国生物工程学会青年委员会委员； 中国细胞生物学青年委员会委员；西安市科协第九届委员会常委；生物学杂志编委；陕西省百人计划（长期项目），陕西省科技创新团队负责人，陕西省杰出青年计划入选者。

    指导“肿瘤糖生物学”研究团队累计承担国家自然科基金项目21项(包括11项面上项目，1项重大培育项目，9项青年基金项目)。近五年发表论文50篇，累计影响因子超过400，包括中科院一区13 篇，二区22篇。至今共指导毕业的硕士研究生30人，指导毕业博士研究生13人。目前指导博士后1人，在读博士研究生4人，在读硕士研究生14人。所指导的研究生获得国家奖学金7人次，省级优秀毕业生2人，校级优秀毕业生5人，校级优秀博士论文2人次。

近年来代表性文章（IF>10）：

1. Cao L, Zhou Y, Lin S, Yang C, Guan Z, Li X, Yang S, Gao T, Zhao J, Fan N, Song Y, Li D, Li X, Li Z, Guan F, Tan Z. The trajectory of vesicular proteomic signatures from HBV-HCC by chitosan-magnetic bead-based separation and DIA-proteomic analysis. J Extracell Vesicles. 2024 Sep;13(9):e12499.（共同通讯作者：IF=15.5）

2. Tan Z, Ning L, Cao L, Zhou Y, Li J, Yang Y, Lin S, Ren X, Xue X, Kang H, Li X, Guan F. Bisecting GlcNAc modification reverses the chemoresistance via attenuating the function of P-gp. Theranostics. 2024 Aug 19;14(13):5184-5199.（通讯作者：IF=12.4）

3. Hongjiao Li, Yi Wang, Fenfang Yang, Shuang Feng , Kaijing Chang , Xinwen Yu, Feng Guan,  Xiang Li. Clonal MDS/AML cells with enhanced TWIST1 expression reprogram the differentiation of bone marrow MSCs. Redox Biology. 2023 Nov:67:102900. doi: 10.1016/j.redox.2023.102900. （共同通讯作者：IF=11.4）

4. Feng J, Wang Y, Li B, Yu X, Lei L, Wu J, Zhang X, Chen Q, Zhou Y, Gou J, Li H, Tan Z, Dai Z, Li X, Guan F. Loss of bisecting GlcNAcylation on MCAM of bone marrow stoma determined pro-tumoral niche in MDS/AML. Leukemia. 2022 Nov 5. doi: 10.1038/s41375-022-01748-1.（通讯作者：IF=12.883）

5. Tan Z, Jiang Y, Liang L, Wu J, Cao L, Zhou X, Song Z, Ye Z, Zhao Z, Feng H, Dong Z, Lin S, Zhou Z, Wang Y, Li X, Guan F. Dysregulation and prometastatic function of glycosyltransferase C1GALT1 modulated by cHP1BP3/ miR-1-3p axis in bladder cancer. J Exp Clin Cancer Res. 2022 Jul 21;41(1):228. （通讯作者：IF=11.16）

6. Jinpeng Wu#, Zengqi Tan#, Hongjiao Li, Meixuan Lin, Yazhuo Jiang, Liang Liang, Qilong Ma, Junjie Gou, Lulu Ning, Xiang Li*, Feng Guan*. Melatonin reduces proliferation and promotes apoptosis of bladder cancer cells by suppressing O-GlcNAcylation of CDK5. Journal of Pineal Research. 2021 Sep 6;e12765. doi: 10.1111/jpi.12765.（通讯作者：IF=12.081）

7. Z Tan, L Cao, Y Wu, B Wang, Z Song, J Yang, L Cheng, X Yang, X Zhou, Z Dai*, X Li*, F Guan*. Bisecting GlcNAc modification diminishes the pro-metastatic functions of small extracellular vesicles from breast cancer cells. J Extracell Vesicles. 2020;10:56-72.（通讯作者：IF=17.337）

8. Li H, Wang Y, Pang X, Xie C, Deeg HJ, Wang H, Wan T, Wu J, Guan F*, Li X*.Elevated TWIST1 expression in myelodysplastic syndromes/ acute myeloid leukemia reduces efficacy of hypomethylating therapy with decitabine. Haematologica. 2020 Jan 30;105(10):235325. doi: 10.3324/haematol.2019.235325.（通讯作者：IF=11.047）

发表文章列表：

2025年

1.       Ma Y, Zhao C, Feng J, Gou J, Kang E, Guan F, Wu Q, Li X. MSC-sEVs exacerbate senescence by transferring bisecting GlcNAcylated GPNMB. Stem Cell Res Ther. 2025 Jan 23;16(1):23. doi: 10.1186/s13287-025-04140-9. PMID: 39849576

2.       Li J, Ren X, Cao L, Min K, Wang M, Lin S, Lei L, Tan Z, Cheng X, Li X, Guan F. Bisecting GlcNAc modification of vesicular GAS6 regulates CAFs activation and breast cancer metastasis. Cell Commun Signal. 2025 Jan 22;23(1):39. doi: 10.1186/s12964-025-02052-y. PMID: 39844194, 通讯作者

3.       Gou J, Bi J, Wang K, Lei L, Feng Y, Tan Z, Gao J, Song Y, Kang E, Guan F, Li X. O-GlcNAcylated FTO promotes m6A modification of SOX4 to enhance MDS/AML cell proliferation. Cell Commun Signal. 2025 Jan 23;23(1):43. doi: 10.1186/s12964-025-02058-6. PMID: 39849461

4.       Wang B, He X, Zhou Y, Tan Z, Li X, Guan F, Lei L. Proximity Labeling-Based Identification of MGAT3 Substrates and Revelation of the Tumor-Suppressive Role of Bisecting GlcNAc in Breast Cancer via GLA Degradation. Cells. 2025 Jan 12;14(2):103. doi: 10.3390/cells14020103. PMID: 39851531, 共同通讯作者

2024年

5.       Yurong Wu, Juhong Yang, Xin Wang, Jia Guo, Zengqi Tan, Feng Guan, Lin Cao. NCAM and attached polysialic acid affect behaviors of breast epithelial cells through differential signaling pathways. Acta Biochim Biophys Sin (Shanghai). 2024 Oct 17;56(11):1584-1593.

6.       Zhuo Li, Na Zhang, Zewen Dong, Xin Wang, Jian Zhou, Juan Gao, Yunyun Yang, Jing Li, Feng Guan, Yue Zhou* and Zengqi Tan*. Integrating transcriptomics, glycomics and glycoproteomics to characterize hepatitis B virus-associated hepatocellular carcinoma. Cell Commun Signal 22, 200 (2024). 

7.       Zhen Zhai, Zhiwei Cui, Yu Zhang, Ping Song, Jinpeng Wu, Zengqi Tan, Shuai Lin, Xiaobin Ma, Feng Guan, Huafeng Kang, Integrated pan-cancer analysis and experimental verification of the roles of meiotic nuclear divisions 1 in breast cancer, Biochemical and Biophysical Research Communications, Volume 739, 2024, 150600. 共同通讯作者

8.       Jiang Y, Wu J, Guan F, Liang L, Wang Y. O-GlcNAcylation determines the function of the key O-GalNAc glycosyltransferase C1GalT1 in bladder cancer. Acta Biochim Biophys Sin (Shanghai). 2024 Aug 8;56(8):1108-1117. 

9.       He X, Wang B, Deng W, Cao J, Tan Z, Li X, Guan F. Impaired bisecting GlcNAc reprogrammed M1 polarization of macrophage. Cell Commun Signal. 2024 Jan 26;22(1):73. doi: 10.1186/s12964-023-01432-6. 最后通讯作者

10.     Yu Zhao, Renlong Li, Weizhen Wang, Haohao Zhang, Qiujin Zhang, Jialu Jiang, Ying Wang, Yan Li, Feng Guan, Yongzhan Nie, O-GlcNAc signaling: Implications for stress-induced adaptive response pathway in the tumor microenvironment, Cancer Letters, Volume 598, 2024, 217101, 中科院一区，共同通讯作者，代表作之一

11.     Zhou Y, Zheng H, Tan Z, Kang E, Xue P, Li X, Guan F. Optimizing and integrating depletion and precipitation methods for plasma proteomics through data-independent acquisition-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2024 Feb 16;1235:124046. doi: 10.1016/j.jchromb.2024.124046. 最后通讯作者

12.     Tan Z, Ning L, Cao L, Zhou Y, Li J, Yang Y, Lin S, Ren X, Xue X, Kang H, Li X, Guan F. Bisecting GlcNAc modification reverses the chemoresistance via attenuating the function of P-gp. Theranostics. 2024 Aug 19;14(13):5184-5199. doi: 10.7150/thno.93879. 中科院一区TOP，最后通讯作者，代表作之一

13.     Feng H, Liang L, Deng W, Gao J, Li X, Guan F. Sialyl Lewis X decorated integrin α3 on small extracellular vesicles promotes metastasis of bladder cancer via enhancing vascular permeability. Angiogenesis. 2024 Sep 2. doi: 10.1007/s10456-024-09947-3. 中科院一区，最后通讯作者，代表作之一

14.     Lin M, Xu X, Zhou X, Feng H, Wang R, Yang Y, Li J, Fan N, Jiang Y, Li X, Guan F, Tan Z. Sialylation on vesicular integrin β1 determined endocytic entry of small extracellular vesicles into recipient cells. Cell Mol Biol Lett. 2024 Apr 1;29(1):46. doi: 10.1186/s11658-024-00562-0. 中科院一区，共同通讯作者

15.     Cao L, Zhou Y, Lin S, Yang C, Guan Z, Li X, Yang S, Gao T, Zhao J, Fan N, Song Y, Li D, Li X, Li Z, Guan F, Tan Z. The trajectory of vesicular proteomic signatures from HBV-HCC by chitosan-magnetic bead-based separation and DIA-proteomic analysis. J Extracell Vesicles. 2024 Sep;13(9):e12499. doi: 10.1002/jev2.12499. PMID: 39207047; PMCID: PMC11359709. 中科院一区TOP，共同通讯作者

16.     Ren X, Lin S, Guan F, Kang H. Glycosylation Targeting: A Paradigm Shift in Cancer Immunotherapy. Int J Biol Sci. 2024 Apr 22;20(7):2607-2621. doi: 10.7150/ijbs.93806. PMID: 38725856; PMCID: PMC11077373. 共同通讯作者

2023年

17.     Li J, Li X, Guan F. What are the diagnostic capabilities of glycans for breast cancer? Expert Rev Mol Diagn. 2023 Jan;23(1):1-7. doi: 10.1080/14737159.2023.2173577. Epub 2023 Feb 3. PMID: 36705933. 最后通讯作者

18.     Ren X, Chang C, Qi T, Yang P, Wang Y, Zhou X, Guan F, Li X. Clusterin Is a Prognostic Biomarker of Lower-Grade Gliomas and Is Associated with Immune Cell Infiltration. Int J Mol Sci. 2023 Aug 29;24(17):13413. doi: 10.3390/ijms241713413. PMID: 37686218; 

19.     Li H, Wang Y, Yang F, Feng S, Chang K, Yu X, Guan F, Li X. Clonal MDS/AML cells with enhanced TWIST1 expression reprogram the differentiation of bone marrow MSCs. Redox Biol. 2023 Sep 21;67:102900. doi: 10.1016/j.redox.2023.102900. Epub ahead of print. PMID: 37748319; 中科院一区TOP

20.     Li H, Wang Y, Feng S, Chang K, Yu X, Yang F, Huang H, Wang Y, Li X, Guan F. Reciprocal regulation of TWIST1 and OGT determines the decitabine efficacy in MDS/AML. Cell Commun Signal. 2023 Sep 22;21(1):255. doi: 10.1186/s12964-023-01278-y. PMID: 37736724; PMCID: PMC10514931. 最后通讯作者

21.     Li H, Yang F, Chang K, Yu X, Guan F^*, Li X^*. The synergistic function of long and short forms of β4GalT1 in p53-mediated drug resistance in bladder cancer cells. Biochim Biophys Acta Mol Cell Res. 2023 Feb;1870(2):119409. doi: 10.1016/j.bbamcr.2022.119409. Epub 2022 Dec 10. PMID: 36513218.  共同通讯作者

22.     Feng J, Wang Y, Li B, Yu X, Lei L, Wu J, Zhang X, Chen Q, Zhou Y, Gou J, Li H, Tan Z, Dai Z, Li X, Guan F. Loss of bisecting GlcNAcylation on MCAM of bone marrow stoma determined pro-tumoral niche in MDS/AML. Leukemia. 2023 Jan;37(1):113-121. doi: 10.1038/s41375-022-01748-1. 中科院一区TOP，最后通讯作者

23.     Li H, Ren X, Pang X, Yang P, Lu Y, Guan F, Wang Y, Li X. LacNAc modification in bone marrow stromal cells enhances resistance of myelodysplastic syndrome cells to chemotherapeutic drugs. Biochim Biophys Acta Mol Cell Res. 2023 Aug;1870(6):119492. doi: 10.1016/j.bbamcr.2023.119492. Epub 2023 May 17. PMID: 37207914.

24.     Lei L, Wang Y, Liu R, Feng J, Tang J, Gou J, Guan F, Li X. Transfer of miR-4755-5p through extracellular vesicles and particles induces decitabine resistance in recipient cells by targeting CDKN2B. Mol Carcinog. 2023 Jun;62(6):743-753. doi: 10.1002/mc.23521. Epub 2023 Feb 24. PMID: 36825759.

2022年

25.     Tan Z, Jiang Y, Liang L, Wu J, Cao L, Zhou X, Song Z, Ye Z, Zhao Z, Feng H, Dong Z, Lin S, Zhou Z, Wang Y, Li X, Guan F. Dysregulation and prometastatic function of glycosyltransferase C1GALT1 modulated by cHP1BP3/ miR-1-3p axis in bladder cancer. J Exp Clin Cancer Res. 2022 Jul 21;41(1):228. doi: 10.1186/s13046-022-02438-7. 中科院一区TOP，最后通讯作者

26.     Li H, Xie C, Lu Y, Chang K, Guan F^*, Li X^*. Exosomal miR92a Promotes Cytarabine Resistance in Myelodysplastic Syndromes by Activating Wnt/β-catenin Signal Pathway. Biomolecules. 2022 Oct 9;12(10):1448. doi: 10.3390/biom12101448. 共同通讯作者

27.     Junjie Gou,Hongjiao Li, Jingjing Bi, Xingchen Pang, Xiang Li, Yi Wang. Transfer of IGF2BP3 Through Ara-C-Induced Apoptotic Bodies Promotes Survival of Recipient Cells. Front Oncol. 2022 May 9;12:801226. doi: 10.3389/fonc.2022.801226. 

28.     Ma Q, Zhuo D, Guan F, Li X, Yang X, Tan Z. Vesicular Ganglioside GM1 From Breast Tumor Cells Stimulated Epithelial-to-Mesenchymal Transition of Recipient MCF-10A Cells. Front Oncol. 2022 Apr 26;12:837930. doi: 10.3389/fonc.2022.837930. 

29.     Zhang S, Ning L, Song Z, Zhao X, Guan F, Yang XF, Zhang J. Activatable Near-Infrared Fluorescent Organic Nanoprobe for Hypochlorous Acid Detection in the Early Diagnosis of Rheumatoid Arthritis. Anal Chem. 2022 Apr 19;94(15):5805-5813. doi: 10.1021/acs.analchem.1c05184. 

30.     Cheng L, Yang F, Tang L, Qian L, Chen X, Guan F, Zhang J, Li G. Electrochemical Evaluation of Tumor Development via Cellular Interface Supported CRISPR/Cas Trans-Cleavage. Research (Wash D C). 2022 Apr 6;2022:9826484. doi: 10.34133/2022/9826484. 

31.     He Xin, Feng Guan*, Lei Lei*. Structure and function of glycosphingolipids on small extracellular vesicles. Glycoconjugate Journal. 2022 Feb 24;1-9. 共同通讯作者

32.     Yutong Fu, LuLu Ning, Jingjing Feng, Xinwen Yu, Feng Guan, Xiang Li*. Dynamic regulation of O-GlcNAcylation and phosphorylation on STAT3 under hypoxia-induced EMT. Cell Signal. 2022 May;93:110277.

33.     Qiushi Chen, Yuanliang Zhang, Keren Zhang, Jie Liu, Huozhen Pan, Xinran Wang, Siqi Li, Dandan Hu, Zhilong Lin, Yun Zhao, Guixue Hou, Feng Guan, Hong Li, Siqi Liu, Yan Ren. Profiling the Bisecting N-acetylglucosamine Modification in Amniotic Membrane via Mass Spectrometry. Genomics Proteomics Bioinformatics. 2022 Feb 2; (22) 00010-9.

34.     Yang C, Guan Z, Pang X, Tan Z, Yang X, Li X, Guan F. Desialylated Mesenchymal Stem Cells-Derived Extracellular Vesicles Loaded with Doxorubicin for Targeted Inhibition of Hepatocellular Carcinoma. Cells. 2022 Aug 25;11(17):2642. doi: 10.3390/cells11172642. PMID: 36078050. 最后通讯作者

2021年

35.     Jinpeng Wu^#, Zengqi Tan^#, Hongjiao Li, Meixuan Lin, Yazhuo Jiang, Liang Liang, Qilong Ma, Junjie Gou, Lulu Ning, Xiang Li^*, Feng Guan^*. Melatonin reduces proliferation and promotes apoptosis of bladder cancer cells by suppressing O-GlcNAcylation of CDK5. Journal of Pineal Research. 2021 Sep 6;e12765. doi: 10.1111/jpi.12765. 中科院一区TOP，最后通讯作者

36.     Minxing Ma*, Dong Guo, Zengqi Tan, Jun Du, Feng Guan, Xiang Li*. Fucosyltransferase 8 regulation and breast cancer suppression by transcription factor activator protein 2γ. Cancer Science. 2021 Aug; 112(8):3190-3204.

37.     Lin Cao, Yue Zhou, Xiang Li, Shuai Lin, Zengqi Tan*, Feng Guan*. Integrating transcriptomics, proteomics, glycomics and glycoproteomics to characterize paclitaxel resistance in breast cancer cells. Journal of Proteomics. 2021 Jul 15;243:104266. 最后通讯作者

38.     Yue Zhou, Zengqi Tan, Peng Xue, Yi Wang, Xiang Li, Feng Guan. High-throughput, in-depth and estimated absolute quantification of plasma proteome using data-independent acquisition/mass spectrometry (“HIAP-DIA”). Proteomics, 2021 Mar; 21(5):e2000264. 最后通讯作者

39.     Lin Cao^# , Yurong Wu^#, Xiuxiu Wang, Xiang Li, Zengqi Tan, Feng Guan*. Role of Site-Specific Glycosylation in the I-Like Domain of Integrin β1 in Small Extracellular Vesicle-Mediated Malignant Behavior and FAK Activation. International Journal of Molecular Science. 2021 Feb 10; 22(4): 1770. doi: 10.3390/ijms22041770. 最后通讯作者

40.     Minxing Ma, Guoxiong Han , Yi Wang , Ziyan Zhao , Feng Guan , Xiang Li. Role of FUT8 expression in clinicopathology and patient survival for various malignant tumor types: a systematic review and meta-analysis. Aging (Albany NY). 2021 Jan 31;13(2):2212-2230.

41.     Hong-Jiao Li , Yi Wang, Bing-Xin Li , Yang Yang , Feng Guan, Xing-Chen Pang, Xiang Li. Roles of ten-eleven translocation family proteins and their O-linked β-N-acetylglucosaminylated forms in cancer development. Oncol Lett. 2021 Jan;21(1):1.

42.     Huining Su , Mimi Wang, Xingchen Pang, Feng Guan , Xiang Li*, Ying Cheng*. When Glycosylation Meets Blood Cells: A Glance of the Aberrant Glycosylation in Hematological Malignancies. Rev Physiol Biochem Pharmacol. 2021;180:85-117.

43.     Xinyue Zhao, Lulu Ning, Xiaoman Zhou, Zhihui Song, Jianjian Zhang, Feng Guan, Xiao-Feng Yang. An Activatable Near-Infrared Fluorescence Hydrogen Sulfide (H 2 S) Donor for Imaging H 2 S Release and Inhibiting Inflammation in Cells. Anal Chem. 2021 Mar 23;93(11):4894-4901.

44.     周岳，杨湘云，黄敏，李想，关锋. Orbitrap Exploris 480质谱在定量蛋白质组学应用中的优化和评测. 生物化学与生物物理进展. Progress in Biochemistry and Biophysics.2021，48（2）：214~226. 最后通讯作者

45.     周岳，黄敏，李想，关锋.  3 种轨道阱质谱仪数据非依赖性扫描的定量分析蛋白质组学性能评测.分析化学. 2021,49(5):820-829. 最后通讯作者

2020年

46.     Zhou X , Zhang J , Song Z , Lu S , Yu Y , Tian J , Li X , Guan F* . ExoTracker: a low-pH-activatable fluorescent probe for labeling exosomes and monitoring endocytosis and trafficking. Chem Commun (Camb). 2020 Nov 26;56(94):14869-14872. doi: 10.1039/d0cc06208a. 共同通讯作者

47.     Z Tan, L Cao, Y Wu, B Wang, Z Song, J Yang, L Cheng, X Yang, X Zhou, Z Dai*, X Li*, F Guan*. Bisecting GlcNAc modification diminishes the pro-metastatic functions of small extracellular vesicles from breast cancer cells. J Extracell Vesicles. 2020;10:56-72. 中科院一区TOP，最后通讯作者，代表作之一

48.     Li H, Wang Y, Pang X, Xie C, Deeg HJ, Wang H, Wan T, Wu J, Guan F*, Li X*.Elevated TWIST1 expression in myelodysplastic syndromes/ acute myeloid leukemia reduces efficacy of hypomethylating therapy with decitabine. Haematologica. 2020 Jan 30;105(10):235325. doi: 10.3324/haematol.2019.235325. 中科院一区TOP，共同通讯作者，代表作之一

49.     Zhou X, Yang G*, Guan F*. Biological Functions and Analytical Strategies of Sialic Acids in Tumor. Cells. 2020 Jan 22;9(2). pii: E273. doi: 10.3390/cells9020273. 最后通讯作者

50.     Xiaoman Zhou; Yanhong Zhai; Changmei Liu; Ganglong Yang; Jia Guo; Chengwen Sun; Guang Li; Xiaowei Qi; Xiang Li; Feng Guan*. Sialidase NEU1 suppresses progression of human bladder cancer cells by inhibiting fibronectin-integrin α5β1 interaction and Akt signaling pathway. Cell Communication and Signaling. 2020 Mar 12;18(1):44. 视频链接：https://www.researchsquare.com/article/rs-25849/v1. 最后通讯作者

51.     Qiushi Chen, Zengqi Tan, Feng Guan*, Yan Ren*.The Essence of Functions and Detection of Bisecting GlcNAc in Cell Biology. Front. Chem. - Chemical Biology, 2020 May, DOI: 10.3389/fchem. 2020.00511. 共同通讯作者

52.     Cheng L, Cao L, Wu Y, Xie W, Li J, Guan F, Tan Z. Bisecting N-Acetylglucosamine on EGFR Inhibits Malignant Phenotype of Breast Cancer via Down-Regulation of EGFR/Erk Signaling. Front Oncol. 2020 Jun 16;10:929. doi: 10.3389/fonc.2020.00929. eCollection 2020. 

2019年

53.     Xiaoman Zhou, Shang Yang, Ganglong Yang, Zengqi Tan, Feng Guan*. Two-step derivatization and mass spectral distinction of α2, 3 and α2, 6 sialic acid linkages on N-glycans by MALDI-TOF. Chinese Chemical Letter. 2019,30(3): 676-680 最后通讯作者

54.     Dinghao Zhuo, Feng Guan*. Ganglioside GM1 promotes contact inhibition of growth by regulating the localization of epidermal growth factor receptor from glycosphingolipids-enriched microdomain to caveolae. Cell proliferation. 2019 Jul;52(4):e12639. doi: 10.1111/cpr.12639. 最后通讯作者

55.     Rui Liu, Yi Wang, Hui Wang, Feng Guan, Zengqi Tan, Xiang Li. Screening differentially expressed proteins from co-cultured hematopoietic cells and bone marrow-derived stromal cells by quantitative proteomics (SILAC) method. Clin Proteomics. 2019 Jul 18;16:32.

56.     Bowen Wang, Zengqi Tan and Feng Guan*.Tumor-Derived Exosomes Mediate the Instability of Cadherins and Promote Tumor Progression. Int. J. Mol. Sci. 2019, 20, 3652; doi:10.3390/ijms20153652 最后通讯作者

2018年

57.     Zengqi Tan, Chenxing Wang, Xiang Li and Feng Guan*. Bisecting N-acetylglucosamine structures inhibit hypoxia-induced epithelial-mesenchymal transition in breast cancer cells. Front. Physiol. 2018. doi: 10.3389/fphys.2018.00210 最后通讯作者

58.     Jin ZC, Kitajima T, Dong W, Huang YF, Ren WW, Guan F, Chiba Y, Gao XD, Fujita M. Genetic disruption of multiple α1,2-mannosidases generates mammalian cells producing recombinant proteins with high-mannose-type N-glycans. J Biol Chem. 2018 Feb 23. pii: jbc.M117.813030. doi: 10.1074/jbc.M117.813030.

59.     Pang X, Li H, Guan F, Li X. Multiple Roles of Glycans in Hematological Malignancies. Front Oncol. 2018 Sep 6;8:364. doi: 10.3389/fonc.2018.00364. eCollection 2018. 

60.     Zhuo D, Li X, Guan F. Biological Roles of Aberrantly Expressed Glycosphingolipids and Related Enzymes in Human Cancer Development and Progression. Front Physiol. 2018 May 3;9:466. doi: 10.3389/fphys.2018.00466. eCollection 2018. 最后通讯作者

61.     Guo D, Guo J, Li X, Guan F. Enhanced motility and proliferation by miR-10b/FUT8/p-AKT axis in breast cancer cells. Oncol Lett. 2018 Aug;16(2):2097-2104. doi: 10.3892/ol.2018.8891. 最后通讯作者

62.     Pang X, Wang Y, Zhang S, Tan Z, Guo J, Guan F, Li X. Altered susceptibility to apoptosis and N glycan profiles of hematopoietic KG1a cells following co culture with bone marrow derived stromal cells under hypoxic conditions. Oncol Rep. 2018 Sep; 40(3):1477-1486. doi: 10.3892/or.2018.6548

2017年

63.     Guo J, Liu C, Zhou X, Xu X, Deng L, Li X, Guan F*. Conditioned Medium from Malignant Breast Cancer Cells Induces an EMT-Like Phenotype and an Altered N-Glycan Profile in Normal Epithelial MCF10A Cells. Int J Mol Sci. 2017 Aug 1;18(8). pii: E1528. 最后通讯作者

64.     Guo Dong, Jia Guo, Xiang Li, and Feng Guan*. Differential effects of Pax3 on expression of polysialyltransferases STX and PST in TGF-β-treated normal murine mammary gland cells. Experimental Biology and Medicine. 2017, 242(2):177-183. 最后通讯作者

65.     Yanli Wu, Ganglong Yang, Mingyong Miao, Feng Guan*. Enrichment and Characterization of Total O-linked Glycans from Glycoproteins by Ultrafiltration Units and Mass Spectrometry, Progress in Biochemistry and Biophysics, 2017; 44 (1) 最后通讯作者

66.     Tian Xiang, Ganglong Yang, Xiaoyu Liu, Yidan zhou, Zhongxiao Fu, Fangfang Lu, Jianguo Gu, Naoyuki Taniguchi, Zengqi Tan, Xi Chen, Yan Xie, Feng Guan*, Xiao-Lian Zhang*. Alteration of N-glycan expression profile and glycan pattern of glycoproteins in human hepatoma cells after HCV infection. BBA-General Subjects, 2017, 1861:1036-1045. 共同通讯作者

2016年

67.     Changmei Liu, Xiang Li and Feng Guan*. Progress of Neu1 and Related Signaling Pathway. Progress in Biochemistry and Biophysics, 2016, 10: 962-969. 最后通讯作者

68.     Ganglong Yang, Luyu Huang, Jiaxu Zhang, Hanjie Yu, Zheng Li, Feng Guan*. Global Identification and Differential Distribution Analysis of Glycans in Subcellular Fractions of Bladder Cells. International Journal of Biological Sciences. 2016. 12(7):799-811. 最后通讯作者

69.     Xiang Li, Xin Wang, Zengqi Tan, Si Chen, Feng Guan*. Role of Glycans in Cancer Cells Undergoing Epithelial–Mesenchymal Transition. Frontiers in Oncology. 2016; 6:33. 最后通讯作者

70.     Ganglong Yang, Wei Lu, Di Yu, Chengwen Sun, Jia Guo, Zheng Li, Feng Guan*. Quantitative analysis of differential proteome expression in epithelial-to-mesenchymal transition of bladder epithelial cells using SILAC method. Molecules 2016, 21(1), 84 最后通讯作者

71.     Yan-Hong Zhai, Chang-Mei Liu, Hui Guo, Gang-Long Yang, Feng Guan*. Effect of The Abnormal Expression of Sialidase Neu1 in Bladder Cancer on Toll Like Receptors. Progress in Biochemistry and Biophysics. 2016, 43(1): 55~62. 最后通讯作者

72.     Shiwei Li, Changmei Liu, Jia Guo, Marcondes, A. M., Deeg, J., Xiang Li, Feng Guan*. Iron overload induced by ferric ammonium citrate triggers reactive oxygen species-mediated apoptosis via both extrinsic and intrinsic pathways in human hepatic cells. Human & experimental toxicology, 2016: 35(6):598-607 最后通讯作者

73.     Xin Wang, Xiang Li, Ying-Nan Zeng, Fa He, Xiao-Min Yang, Feng Guan*. Enhanced expression of polysialic acid correlates with malignant phenotype in breast cancer cell lines and clinical tissue samples. International Journal of Molecular Medicine, 2016, 37(1): 197-206. 最后通讯作者

2015年

74.     Feng Guan, Xiang Li, Jia Guo, Ganglong Yang, Xiang Li*. Ganglioside-magnetosome complex formation enhances uptake of gangliosides by cells. International Journal of Nanomedicine 2015:10: 6919-30. 第一作者

75.     Feng Guan*, Zengqi Tan, Xiang Li, Xingchen Pang, Yunlin Zhu, Dongliang Li, Ganglong Yang. A lectin-based isolation/ enrichment strategy for improved coverage of N-glycan analysis. Carbohydrate Research, 2015.416: 7-13. 第一作者

76.     Wei Lu, Gang-Long Yang, Peng Xue, Chang-Mei Liu, Feng Guan*. Quantitative Analysis of Integrin α6 in Bladder Cancer Cell Lines. Progress in Biochemistry and Biophysics, 2015, 42(5): 468~475 最后通讯作者

77.     Feng Guan*, Xin Wang, Fa He. Promotion of Cell Migration by Neural Cell Adhesion Molecule (NCAM) Is Enhanced by PSA in a Polysialyltransferase-Specific Manner. PLOS ONE, 2015. 第一作者

78.     Ganglong Yang, Zhipeng Xu, Wei Lu, Xiang Li, Chengwen Sun, Jia Guo, Peng Xue , Feng Guan*. Quantitative Analysis of Differential Proteome Expression in Bladder Cancer vs. Normal Bladder Cells Using SILAC Method. PLOS ONE, 2015. 最后通讯作者

79.     Xiang Li, Dongliang Li, Xingchen Pang, Ganglong Yang, H. Joachim Deeg, Feng Guan*. Quantitative Analysis of Glycans, Related Genes, and Proteins in Two Human Bone Marrow Stromal Cell Lines using an Integrated Strategy. Experimental Hematology, 2015 最后通讯作者

80.     Jia Guo, Yicheng Wang, Bo Song, Xin Wang, Ganglong Yang, Feng Guan*. Identification and functional characterization of intracellular sialidase NeuA3 from Streptomyces avermitilis. Process Biochemistry, 2015.2015, 50(5): 752-758. 最后通讯作者

81.     Jia Guo, Bo Song, Xiang Li, Chenhui He, Ganglong Yang, Feng Guan*. Down-regulation of gangliotetraosylceramide (Gg4) and β3GalT4 gene expression by Smads during TGF-β-induced epithelial-mesenchymal transition. Molecular Medicine Reports. 2015, 11(3): 2241-2247. 最后通讯作者

2014年以前

82.     Ganglong Yang, Zengqi Tan, Wei Lu, Jia Guo, Hanjie Yu, Jingmin Yu, Chengwen Sun, Xiaowei Qi, Zheng Li*, Feng Guan*. Quantitative glycome analysis of N-glycan patterns in bladder cancer vs. normal bladder cells using an integrated strategy. Journal of proteome research. 2015,14, 639-653.

83.     Jia Guo, Xiang Li, Zengqi Tan, Wei Lu, Ganglong Yang, Feng Guan*. Alteration of N-glycans and Expression of Their Related Glycogenes in the Epithelial-Mesenchymal Transition of HCV29 Bladder Epithelial Cells. Molecules. 2014, 19(12), 20073-20090.

84.     Zengqi Tan, Wei Lu, Xiang Li, Ganglong Yang, Jia Guo, Hanjie Yu, Zheng Li, Feng Guan*. Altered N-glycan expression profile in epithelial-to-mesenchymal transition of NMuMG cells revealed by an integrated strategy using mass spectrometry and glycogene and lectin microarray analysis. J Proteome Res. 2014, 13 (6), 2783–2795

85.     Feng Guan*, Kazuko Handa, Sen-itiroh Hakomori. Regulation of epidermal growth factor receptor through interaction of ganglioside GM3 with GlcNAc of N-linked glycan of the receptor: Demonstration in ldlD cells. Neurochemical Research. 2011, 36(9) 1645-1653.

86.     Feng Guan, Lana Schaffer, Kazuko Handa, Sen-itiroh Hakomori. Functional Role of Gangliotetraosylceramide in Epithelial-to-Mesenchymal Transition Process Induced by Hypoxia and by TGFβ. The FASEB Journal 2010, 24 (12) 4889-4903.

87.     Feng Guan, Kazuko Handa and Sen-itiroh Hakomori. Specific glycosphingolipids mediate epithelial-to-mesenchymal transition of human and mouse epithelial cell lines. Proceedings of the National Academy of Sciences. 2009, 106 (18) 7461-7466.