雷蕾，西北大学副教授，博士生导师。2013 年毕业于北京大学，并于同年进入西北大学生命科学院，从事结肠癌的糖生物学研究。在职期间获得国家自然科学面上基金、青年基金；陕西省科技厅青年项目与面上项目；陕西省教育厅青年项目；西部资源生物与现代生物技术教育部重点实验室开放基金的支持。作为副主编由科学出版社出版“十二五国家重点图书出版规划教材”两部：《复杂疾病的遗传咨询》和《基因健康信息学》。

教育经历

2009/09-2013/06，北京大学，基础医学院，神经生物学系，理学博士

2004/09-2009/06，北京大学，基础医学院，医学学士

科研与学术工作经历

2019/3-至今, 西北大学, 生命科学学院, 副教授

2019/10-2020/12, 马萨诸塞州立大学, 食品科学系, 访问学者

2013/7-2019/3, 西北大学, 生命科学学院, 讲师

主要研究方向：

研究方向一：肿瘤糖生物学，通过基因组学与糖组学技术研究营养与结肠癌的关系。

研究方向二：通过研究结直肠癌发病的分子机制寻找遗传标志物，为结直肠癌的早期筛查，精准治疗和预后诊断奠定基础。

Email: leilei@nwu.edu.cn

承担的科研项目

2024 国家自然科学基金面上项目（32471333），在研，主持

2024 陕西省（化学生物）基础研究院科研计划项目（23JHQ065），在研，主持

2022 陕西省科技厅面上项目（2022JM-522），结题，主持

2019 陕西省科技厅青年项目（2019JQ-538），结题，主持

2018 西部资源生物与现代生物技术教育部重点实验室开放基金，结题，主持

2018 陕西省教育厅青年项目（18JK0796），结题，主持

2015 国家自然科学基金青年基金项目（31401081），结题，主持

主要研究成果

1. Lei Lei, Juan Tang, Yuejiao Lv, Bingyi Jia, Wenqing Cai, Shuangshuang Sheng, Keying Li, Zhiwen Shi, Ning Fan, Zengqi Tan, Xiang Li, Feng Guan; Dietary palmitic acid inhibits colorectal cancer progression through enhancing bisecting GlcNAc, JCI insight, 2026

2. Lei Lei^#, Nan Jing^#, Minhao Xie, Jianan Zhang, Bruce D. Hammock, Jun Yang, Guodong Zhang; LC-MS/MS-Based Targeted Lipidomic Analysis of Obesity-Related Colorectal Cancer: Potential Roles of the CYP Eicosanoid Pathway, The Journal of Nutrition, 2025

3. Bowen Wang, Xin He, Yue Zhou, Zengqi Tan, Xiang Li, Feng Guan*, Lei Lei*; Proximity Labeling-Based Identifcation of MGAT3 Substrates and Revelation of the Tumor-Suppressive Role of Bisecting GlcNAc in Breast Cancer via GLA Degradation, Cells, 2025

4. Lei Lei^#, Yi Wang^#, Rui Liu, Jingjing Feng, Juan Tang, Junjie Gou, Feng Guan, Xiang Li*; Transfer of miR-4755-5p through extracellular vesicles and particles induces decitabine resistance in recipient cells by targeting CDKN2B, Molecular Carcinogenesis, 2023

5. Lei Lei, Qing Cao, Guoyan An, Yuejiao Lv, Juan Tang, Jin Yang*; DDI2 promotes tumor metastasis and resists antineoplastic, Apoptosis, 2022

6. Xin He, Feng Guan, Lei Lei*; Structure and function of glycosphingolipids on small extracellular vesicles, Glycoconjugate Journal, 2022

7. Lei Lei; Jun Yang; Jianan Zhang; Guodong Zhang*; The lipid peroxidation product EKODE exacerbates colonic inflammation and colon tumorigenesis, Redox Biology, 2021, 101880: 2213-2317.

8. Lei Lei; Jianan Zhang; Eric A. Decker; Guodong Zhang*; Roles of Lipid Peroxidation-Derived Electrophiles in Pathogenesis of Colonic Inflammation and Colon Cancer, Frontiers in Cell and Developmental Biology, 2021, 2021(9): 665591.

9. Shuzhen Liu; Guoyan An; Qing Cao; Tong Li; Xinyu Jia; Lei Lei*; The miR-106b/NR2F2-AS1/PLEKHO2 Axis Regulates Migration and Invasion of Colorectal Cancer through the MAPK Pathway, International Journal of Molecular Sciences, 2021, 2021(22): 5877.

10. Shuzhen Liu; Qing Cao; Guoyan An; Bianbian Yan; Lei Lei*; Identification of the 3-lncRNA Signature as a Prognostic Biomarker for Colorectal Cancer, International Journal of Molecular Sciences, 2020, 2020(21): 9359.

11. Qing Cao^#; Zewen Dong^#; Shuzhen Liu; Guoyan An; Bianbian Yan; Lei Lei*; Construction of a metastasis-associated ceRNA network reveals a prognostic signature in lung cancer, Cancer Cell Int, 2020, (2020) 20:208.

12. Lei Lei*; Guoyan An; Ziqing Zhu; Shuzhen Liu; Yutong Fu; Xiaonan Zeng; Qing Cao; Bianbian Yan; C8orf48 inhibits the tumorigenesis of colorectal cancer by regulating the MAPK signaling pathway, Life Sciences, 2020, 266(2021): 0-118872.

13. Lei Lei; Xiaojuan Zhao; Shuzhen Liu; Qing Cao; Bianbian Yan; Jin Yang*; MicroRNA-3607 inhibits the tumorigenesis of colorectal cancer by targeting DDI2 and regulating the DNA damage repair pathway, Apoptosis, 2019, 24(7-8): 662-672.

14. Hongjuan He; Xiaojuan Zhao; Ziqing Zhu; Le Du; Erfei Chen; Shuzhen Liu; Qiqi Li; Jing Dong; Jin Yang; Lei Lei*; MicroRNA-3191 promotes migration and invasion by downregulating TGFBR2 in colorectal cancer, Journal of Biochemical and Molecular Toxicology, 2019, 33(6): 0-e22308.

15. Hongjuan He^#, Lei Lei^#, Erfei Chen, Xiaona Xu, Lili Wang, Junqiang Pan, Fangfang Yang, Min Wang, Jing Dong, Jin Yang* The screening of the functional microRNA binding site SNPs in sporadic colorectal cancer genes. Cancer Biology & Therapy  ISSN: 1538-4047 April 23 2017

16. Lei Lei, Xu Cao, Fan Yang, Di-Jing Shi, Yi-Quan Tang, Jie Zheng and KeWei Wang*; A TRPV4 Channel C-Terminal Folding Recognition Domain Critical For Trafficking And Function, Journal of Biological Chemistry, VOL.288 NO.15, pp.10427-10439, April 12, 2013

获得的荣誉及表彰

西北大学优秀教师 （2019、2024）

《陕西高等学校第四届青年教师教学竞赛》二等奖

《西北大学第十二届青年教师讲课比赛》一等奖

指导本科生获得2024年iGEM 全球金奖

指导本科生获得第八届全国大学生生命科学大赛陕西省一等奖，国家二等奖