Paper Publications

Structural insights into target DNA recognition and cleavage by the CRISPR-Cas12c1 system.Nucleic Acids Research,2022,50(20):11820-11833

Mechanistic insights into the R-loop formation and cleavage in CRISPR-Cas12i1.Nature Communications,2021,12(3476):1-13

Functional features and current applications of the RNA-targeting type VI CRISPR-Cas systems.Advanced Science,2021,2004685(1-23

Two HEPN domains dictate CRISPR RNA maturation and target cleavage in Cas13d.Nature Communications,2019,10(2544):1-11

Structural insights into Cas13b-guided CRISPR RNA maturation and recognition.Cell Research,2018,28(12):1198-1201

Human 3-alplha hydroxysteroid dehydrogenase type 3: structural clues of 5α-DHT reverse binding and enzyme down-regulation decreasing MCF7 cell growth.Biochemical Journal,2016,473(8):1037-1046

Human 3-alpha hydroxysteroid dehydrogenase type 3 (3α-HSD3): the V54L mutation restricting the steroid alternative binding and enhancing the 20α-HSD activity.Journal of Steroid Biochemistry and Molecular Biology,2014,141(135-143

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