主要研究领域:
主要从事活性分子与营养健康等方面的研究工作,聚焦重组胶原蛋白及人参皂苷生物学功效探究。
研究生招生学科:
(1) 学术学位: 化学工程与技术 (0817)
(2) 专业学位: 生物与医药 (0860),学科方向: 制药工程。
教育经历:
2016.09-2022.06,博士,生物化工,西北大学;
2012.09-2016.07,学士,应用化学,宝鸡文理学院。
工作经历:
2023.2-至今,西安巨子生物基因技术股份有限公司,博士后;
2023.1-至今,西北大学,副教授。
主持科研项目:
1. 国家自然科学基金青年项目,人参皂苷Rh4靶向HK2激活T细胞免疫抗肝癌机制研究,22408292,2025.01-2027.12,30万,主持,在研。
2. 国家重点研发计划项目子课题,糖基化重组胶原蛋白医用产品的开发及其功效评价,2023YFA0914304,2023.12-2028.11,63万,主持,在研。
3. 陕西省博士后科研项目一等资助,人参皂苷Rk1调控肠道菌群改善肥胖作用及机制,2024BSHYDZZ006,15万,主持,在研。
4. 中国博士后科学基金第75批面上项目,基于“肠-肝轴”探讨人参皂苷Rk1防治非酒精性脂肪肝作用及机制研究,2024M752604,8万,主持,在研。
5. 陕西省自然科学基础研究计划青年项目,人参皂苷Rk1靶向FXR调控肝肠轴改善NASH机制探究,2024JC-YBQN-0126,2024.01-2026.12,5万,主持,在研。
6. 西安市博士后创新基地博士后资助项目,人参皂苷Rk1改善NASH机制探究,2023.01-2024.12,5万,主持,在研。
7. 西安市科协青年人才托举计划项目,人参皂苷Rk1靶向FXR调控肝肠轴改善非酒精性脂肪肝机制研究,959202413029,2024.07-2026.06,0.8万,主持,在研。
代表性论文:
1. Linlin Qu*, Yingcong Huang, Yuqing Wu, Lei He, Yannan Liu, Zhiqi Chen, Xiaoxuan Ma, Daidi Fan*. Ginsenoside Rk3 Treats Corneal Injury Through the HMGB1/TLR4/NF-κB Pathway. Journal of Agricultural and Food Chemistry, 2024, 72, 24387-24399.
2. Linlin Qu#, Yannan Liu#, Jianjun Deng#, Xiaoxuan Ma, Daidi Fan*. Ginsenoside Rk3 is a novel PI3K/AKT-targeting therapeutics agent that regulates autophagy and apoptosis in hepatocellular carcinoma. Journal of Pharmaceutical Analysis, 2023, 13, 463-482.
3. Lei Yao#, Linlin Qu#, Jianjun Deng, Chenhui Zhu, Rongzhan Fu, Min Jiang, Daidi Fan*. Ginsenoside Rh4 alleviates idiopathic pulmonary fibrosis by enhancing the CXCL9-CXCR3 axis. Food Frontiers, 2024, 5, 1370-1386.
4. Linlin Qu, Xiaoxuan Ma, Daidi Fan*. Ginsenoside Rk3 suppresses hepatocellular carcinoma development through targeting the gut-liver axis. Journal of Agricultural and Food Chemistry, 2021, 69, 10121-10137. (封面文章)
5. Linlin Qu#, Rongzhan Fu#, Xiaoxuan Ma, Daidi Fan*. Protopanaxatriol-type saponin protects against acetaminophen-induced liver injury through ROS-mediated JNK pathway. Journal of Functional Foods, 2021, 86, 104672.
6. Linlin Qu#, Rongzhan Fu#, Xiaoxuan Ma, Daidi Fan*. Hepatoprotective effects of ginsenoside Rk3 in acetaminophen-induced liver injury in mice by activation of autophagy. Food & Function, 2021,12, 9128-9140.
7. Linlin Qu, Yanyan Zhu, Yannan Liu, Haixia Yang, Chenhui Zhua, Pei Ma, Jianjun Deng*, Daidi Fan*. Protective effects of ginsenoside Rk3 against chronic alcohol-induced liver injury in mice through inhibition of inflammation, oxidative stress, and apoptosis. Food and Chemical Toxicology, 2019, 126, 277-284.
8. Linlin Qu#, Qingqing Liu#, Qi Zhang, Xingxia Tuo, Daidi Fan, Jianjun Deng*, Haixia Yang*. Kiwifruit seed oil prevents obesity by regulating inflammation, thermogenesis, and gut microbiota in high-fat diet-induced obese C57BL/6 mice. Food and Chemical Toxicology, 2019, 125, 85-94.
9. Linlin Qu#, Qingqing Liu#, Qi Zhang, Dan Liu, Chao Zhang, Daidi Fan, Jianjun Deng*, Haixia Yang*. Kiwifruit seed oil ameliorates inflammation and hepatic fat metabolism in high-fat diet-induced obese mice. Journal of Functional Foods, 2019, 52, 715-723.
10. Xiaodan Xue#, Yannan Liu#, Linlin Qu#, Cuiying Fan, Pingkai Ouyang, Daidi Fan*. Ginsenoside Rh3 Inhibits Lung Cancer Metastasis by Targeting Extracellular Signal-Regulated Kinase: A Network Pharmacology Study. Pharmaceuticals, 2022, 15, 758.
教材/专著:
1. Linlin Qu, Jianjun Deng, Daidi Fan*. Scale-up and Chemical Process for Microbial Production of Plant-Derived Bioactive Compounds (Chepter 12: Examples for successful commercial production of plant-derived bioactive compounds). ELSEVIER, 2024, Paperback ISBN: 9780443155840.
教学:
1. 西北大学2023年度本科人才培养建设项目高水平教材建设项目,《生物反应工程与反应器理论》,2023年,范代娣、屈琳琳、刘彦楠、雷桓、李伟娜,在研。
2. 西北大学研究生精品教材建设项目,《生化反应器理论》,2022年,范代娣、邓建军、屈琳琳,已结题。
3. 西北大学2023年专业学位研究生优秀教学案例三等奖,底盘细胞的选择及构建--《生化反应器理论》的理论及实践,2023年,范代娣、屈琳琳、邓建军、刘彦楠、雷桓、李伟娜。