专业方向：化学生物学；有机化学

研究兴趣：功能有机分子化学；生物体系分子探针；衰老可视化诊疗

个人简介：郭媛，女，1979年11月生，西北大学化学与材料科学学院教授、博士生导师，兼任法国国立奥尔良大学特邀教授；Acta Materia Medica 、《精细化工》、Chinese Chemical Letters 等杂志编委。本、硕、博毕业于西北大学；第四军医大学、法国国家科研中心奥尔良ICOA研究所博士后（获法中科学与应用基金会FFCSA奖学金）。主要从事化学生物学、有机化学的教学、科研工作，主讲本科《有机化学》、研究生《化学生物学》等课程。

目前围绕生物体系分子探针、药物化学生物学、衰老精准示踪与干预等开展研究工作，先后主持国家自然科学基金项目5项，以课题负责人承担国家自然科学基金重点项目1项（负责1/2）。以通讯作者/第一作者在Nature Aging、Angew. Chem. Int. Ed.、Chem. Sci.、Anal. Chem.等国际知名学术刊物上发表SCI论文五十余篇（中科院一区18篇），获授权国家发明专利10项。荣获西北大学第八届青年教师讲课比赛一等奖（2009）、西北大学化学与材料科学学院讲课比赛特等奖（2015）。作为主要完成人，荣获陕西省科学技术一等奖（2005）、三等奖（2010）。入选陕西省“杰出青年”科学基金（2020）、西安市三八红旗手（2022），荣获西安青年科技人才奖（2016）。

Prof. Yuan Guo, born in 1979, China, obtained her B. S. in 2001 and Ph. D. in 2006 from Department of Chemistry, Northwest University, China. She spent two years in France, as Post-doctoral research associate (2012-2014) at Institut de Chimie Organique et Analytique, Université d'Orléans, UMR CNRS, France. She served as Associate Professor of Chemistry (2009-2015) and Full Professor of Chemistry (2015-present) at Northwest University. Research interests: Chemical Biology; Molecular Probes in Biological Systems; Optical Probes for Drug Study; Diagnostic Agents; Fluorescent Probes.

Publications in Recent 5 Years：

29. Guo Yuan* and Li Jian*; A senolytic strategy integrating multiple technologies delays aging. Nature Aging, 2023, DOI: 10.1038/s43587-023-00369-2. (Research Briefing)

28. Shi Donglei; Liu Wenwen; Gao Ying; Li Xinming; Huang Yunyuan; Li Xiaokang; James Tony D.; Guo Yuan*; Li Jian*; Photoactivatable senolysis with single-cell resolution delays aging. Nature Aging, 2023, DOI: 10.1038/s43587-023-00360-x.

27. Gao Ying; Hu Yulu; Liu Qimeng; Li Xiaokang; Li Xinming; Kim Chu-Young; James Tony D.; Li Jian*; Chen Xi*; Guo Yuan*. Two‐dimensional design strategy to construct smart fluorescent probes for the precise tracking of senescence. Angewandte Chemie International Edition, 2021, 60, 10756-10765. (Hot paper) 

26.  Song Yihe; Li Xinming; Shi Donglei; Sun Tianyue; Liu Wenwen; Li Xiaokang; Qiao Sicong; Chen Xin; Guo Yuan*; Li Jian*. A senolysis-based theragnostic prodrug strategy towards chronic renal failure. Chemical Science, 2022, 13, 11738-11745. (Back cover)

25. Tian Jingye; Shi Donglei; Zhang Yanhui; Li Xiaokang; Li Xinming; Teng Hao; James Tony D.; Li Jian*; Guo Yuan*. Stress response decay with aging visualized using a dual-channel logic-based fluorescent probe. Chemical Science, 2021, 12, 13483-13491.

24. Li Xiaokang; Qiu Wenjing; Li Jinwen; Chen Xi; Hu Yulu; Gao Ying; Shi Donglei; Li Xinming; Lin Huiling; Hu Zelan; Dong Guoqiang; Sheng Chunquan; Jiang Bei; Xia Conglong; Kim Chu-Young; Guo Yuan*; Li Jian*. First-generation species-selective chemical probes for fluorescence imaging of human senescence-associated β-galactosidase. Chemical Science, 2020, 11, 7292-7301. (Front cover)

23. Shi Donglei; Chen Shuqiang; Dong Biao; Zhang Yanhui; Sheng Chunquan; James Tony D.; Guo Yuan*. Evaluation of HOCl-generating anticancer agents by an ultrasensitive dual-mode fluorescent probe. Chemical Science, 2019, 10, 3715-3722. (Back cover)

22. Yang Wanzhen; Zhang Yanhui; Teng Hao; Liu Na; Sheng Chunquan*; Guo Yuan*. Role of azole drugs in promoting fungal cell autophagy revealed by an NIR fluorescence-based theranostic probe. Analytical Chemistry, 2022, 94, 7092-7099. 

21. Li Jin; Yin Xinchi; Li Bin; Li Xiaokang; Pan Yuanjiang; Li Jian; Guo Yuan*. Spiropyran in situ switching: A real-time fluorescence strategy for tracking DNA G-quadruplexes in live cells. Analytical Chemistry, 2019, 91, 5354-5361. 

20. Tian Xinrong; Li Jin; Zhang Yanhui; Gao Ying; Afzal Muhammad Wasim; Wang Aoli; James Tony D.; Bai Yinjuan*; Guo Yuan*. A spiropyran with low pKa for tracking DNA G-quadruplexes and revealing the dissipation of ΔΨm with senescence using an in-situ switching strategy. Sensors and Actuators B: Chemical, 2022, 359, 131618.

19. Afzal Muhammad Wasim; Duan Kaixuan; Zhang Yanhui; Gao Ying; Qin Bo; Wang Guangwei; Lei Lin; Tang Haoyang*; Guo Yuan*. A rhodol-based fluorescent probe with a Pair of hydrophilic and rotatable wings for sensitively monitoring intracellular polarity.  Chemistry-An Asian Journal, 2022, 17, e202200063. (VIP paper)

18. Afzal Muhammad Wasim; Wang Shixiong; Gao Ying; Qin Bo; Tian Xinrong; Zhang Yanhui; Tang Haoyang; Guo Yuan*. A highly water-soluble rhodol-based fluorescent probe for the organic-solvent independent sensing of biological hypochlorous acid. Dyes and Pigments, 2022, 204, 110435.

17. Li Xinming; Shi Donglei; Song Yihe; Xu Yixiang; Gao Ying; Qiu Wenjing; Chen Xin; Li Xiaokang; Huang Yunyuan; Feng Yanjun; Li Baoli*; Guo Yuan*; Li Jian*. Specific tracking of monoamine oxidase A in heart failure models by a far-red fluorescent probe with an ultra large Stokes shift. Chinese Chemical Letters, 2022, 33, 1572-1576.

16. Shi Donglei; Liu Wenwen; Wang Guangwei; Guo Yuan*; Li Jian*. Small-molecule fluorescence-based probes for aging diagnosis. Acta Materia Medica, 2022, 1, 4-23. 

15. Gao Liang-Liang; Pang Shulin; Gao Ying; Shi Donglei*; Guo Yuan*. Recent development of organic small-molecule and nanomaterial fluorescent probes for hydrazine. Advanced Agrochem, 2022, 1, 22-38. 

14. Wu Ying; Zhang Yanhui; Chen Xi; Hu Yulu; Dong Guoqiang; Guo Yuan*; Sheng Chunquan*. A theranostic probe of indoleamine 2,3-dioxygenase 1 (IDO1) for small molecule cancer immunotherapy. European Journal of Medicinal Chemistry, 2021, 213, 113163.

13. Tang Haoyang; Qiang Xinyu; Gao Ying; Teng Hao*; Chen Xi; Zhang Yanhui; Tian Jingye; Qin Bo; Guo Yuan*. Real-time tracking and dual-mode imaging of hypochlorous acid in vivo by a small-sized fluorescence probe. Dyes and Pigments, 2021, 188, 109219.

12. Shi Donglei; Hu Linghao; Li Xinming; Liu Wenwen; Gao Ying; Li Xiaokang; Jiang Bei; Xia Conglong; Guo Yuan*; Li Jian*. Lysosomal polarity increases with aging as revealed by a lysosome-targetable near-infrared fluorescent probe. Sensors and Actuators B: Chemical, 2020, 319: 128302.

11. Teng Hao; Tian Jingye; Sun Donghuan; Xiu Mengxue; Zhang Yanhui; Qiang Xingyu; Tang Haoyang*; Guo Yuan*. A mitochondria-specific fluorescent probe based on triazolopyridine formation for visualizing endogenous hypochlorous acid in living cells and zebrafish. Sensors and Actuators B: Chemical, 2020, 319: 128288.

10. Zhang Yanhui; Teng Hao; Gao Ying; Afzal Muhammad Wasim; Tian Jingye; Chen Xi; Tang Haoyang; James Tony D.; Guo Yuan*. A general strategy for selective detection of hypochlorous acid based on triazolopyridine formation. Chinese Chemical Letters, 2020, 31: 2917-2920. (Front cover)

9. Hu Linghao; Shi Donglei; Li Xinming; Zhu Jin; Mao Fei; Li Xiaokang; Xia Conglong; Jiang Bei; Guo Yuan*; Li Jian*. Curcumin-based polarity fluorescent probes: Design strategy and biological applications. Dyes and Pigments, 2020, 177: 108320.

8. Liu Qimeng; Li Anyang; Li Xiaokang; Li Bin; Zhang Yanhui; Li Jian; Guo Yuan*. Selective visualization of live-cell mitochondrial thiophenols and their induced oxidative stress process by a rationally designed rhodol-based fluorescent probe. Sensors and Actuators B: Chemical, 2019, 283: 820-830.

7. Li Jin; Gao Ying; Guo Haoran; Li Xiaokang; Tang Haoyang; Li Jian; Guo Yuan*. A novel colorimetric and ratiometric fluorescent probe for selective detection of bisulfite in real samples and living cells. Dyes and Pigments, 2019, 163: 285-290.

6. Li Jin; Li Xiaokang; Jia Jianbo; Chen Xi; Lv Yinjuan; Guo Yuan*; Li Jian*. A ratiometric near-infrared fluorescence strategy based on spiropyran in situ switching for tracking dynamic changes of live-cell lysosomal pH. Dyes and Pigments, 2019, 166: 433-442.

5. Liu Qimeng; Wang Huan; Guo Haoran; Guo Yuan*. A highly selective coumarin-based fluorescent probe for detecting Fe3+ in pure water systems and living cells. Chinese Journal of Inorganic Chemistry, 2019, 35: 923-929.

4. Wang Huan; Shi Donglei; Li Jin; Tang Haoyang; Li Jian; Guo Yuan*. A facile fluorescent probe with a large Stokes shift for sequentially detecting copper and sulfide in 100% aqueous solution and imaging them in living cells. Sensors and Actuators B: Chemical, 2018, 256: 600-608.

3. Tang Haoyang; Gao Ying; Li Bin; Li Changwei; Guo Yuan*. Reaction-based colorimetric and ratiometric fluorescent probe for highly selective detection of silver ions. Sensors and Actuators B: Chemical, 2018, 270: 562-569.

2. Zhang Yanhui; Ma Lin; Tang Chunchao; Pan Shengnan; Shi Donglei; Wang Shaojing; Li Minyong*; Guo Yuan*. A highly sensitive and rapidly responding fluorescent probe based on a rhodol fluorophore for imaging endogenous hypochlorite in living mice. Journal of Materials Chemistry B, 2018, 6: 725-731. (Front cover)

1. Wang Shaojing; Li Jin; Gao Ying; Guo Yuan*. Highly selective and sensitive 2-(2’-hydroxyphenyl) benzothiazole-based turn-on fluorescent probes for detecting and imaging bisulfite in living cells. Asian Journal of Organic Chemistry, 2018, 7: 563-569.