主要研究方向

       功能基因组学、表观遗传学、开发新方法

主持及参与科研项目

(1) 国家自然科学基金青年科学基金项目，32100468，基于SELEX方法研究增强子差异甲基化影响前列腺癌风险的分子机制，2022.1-2024.12，30万元，在研，主持

(2) 中国博士后科学基金面上项目，2019M663794，旱生植物霸王抗旱的机理研究，2019.11-2021.7，8万元，已结题，主持

(3) 国家自然科学基金面上项目，32070596，开发新方法研究内源逆转录病毒HERV-H在胚胎发育中调控染色质高级结构的分子机理，2021.1-2024.12，58万元，在研，参与

(4) 国家自然科学基金面上项目，32270634，对CTCF结合位点附近染色质DNA去甲基化分子机制的研究，2023.1-2026.12，54万元，在研，参与

已发表论文

(1)   Fan Ligang#, Wang Tingting#, Hua Canfeng#, Sun Wenju#, Li Xiaoyu, Grunwald Lucas, Liu Jingui, Wu Nan, Shao    Xiaolong, Yin Yimeng, Yan Jian*, Deng Xin*, A compendium of DNA-binding specificities of transcription factors in Pseudomonas syringae, Nature Communications, 2020, 11(1).

(2)   Wang Tingting#, Sun Wenju Sun#, Fan Ligang#, Hua Canfeng#, Wu Nan, Fan Shaorong, Zhang Jilin, Deng Xin*, Yan Jian*, An atlas of the binding specificities of transcription factors in Pseudomonas aeruginosa directs prediction of novel regulators in virulence, Elife, 2021, 10: e61885. 

(3)   Shaorong Fan#, Wenju Sun#, Ligang Fan#, Nan Wu, Wei Sun, Haiqian Ma, Siyuan Chen, Zitong Li, Yu Li, Jilin Zhang, Jian Yan*. The highly conserved RNA-binding specificity of nucleocapsid protein facilitates the identification of drugs with broad anti-coronavirus activity. Computational and Structural Biotechnology Journal, 2022, 20: 5040 -5044.

(4) Fan Ligang, Zhao Lei, Hu Wei, Li Weina, Novák Ondřej, Strnad Miroslav, Simon Sibu, Friml Jiří, Shen Jinbo, Jiang Liwen, Qiu Quan-Sheng*, Na⁺, K⁺/H⁺ antiporters regulate the pH of endoplasmic reticulum and auxin-mediated development, Plant Cell and Environment, 2018, 41(4): 850-864.

(5) Fan Ligang#, Wang Guannan#, Hu Wei, Pantha Pramod, Tran Kieu-Nga, Zhang Hua, An Lizhe, Dassanayake Maheshi*, Qiu Quan-Sheng*, Transcriptomic view of survival during early seedling growth of the extremophyte Haloxylon ammodendron, Plant Physiology and Biochemistry, 2018, 132: 475-489.

(6) Tan Daisylyn Senna#, Chen Yanpu#, Gao Ya, Bednarz Anastasia, Wei Yuanjie, Malik Vikas, Ho Derek Hoi-Hang, Weng Mingxi, Ho Sik Yin, Srivastava Yogesh, Velychko Sergiy, Yang Xiaoxiao, Fan Ligang, Kim Johnny, Graumann Johannes, Stormo Gary D, Braun Thomas, Yan Jian, Schöler Hans R, Jauch Ralf*, Directed Evolution of an Enhanced POU Reprogramming Factor for Cell Fate Engineering, Molecular Biology and Evolution, 2021, 38(7): 2854-2868. 

(7) Yi Wenkai#, Li Jingyu#, Zhu Xiaoxuan#, Wang Xi#, Fan Ligang, Sun Wenju, Liao Linbu, Zhang Jilin, Li Xiaoyu, Ye Jing, Chen Fulin, Taipale Jussi, Chan Kui Ming*, Zhang  Liang*, Yan Jian*, CRISPR-assisted detection of RNA-protein interactions in living cells, Nature Methods, 2020, 17(7): 685-688. 

(8) Lv Shasha#, Wang Lu#, Zhang Xiao, Li Xiaojiao, Fan Ligang, Xu Yanli, Zhao Yingjia, Xie Huichun, Sawchuk Megan G, Scarpella Enrico, Qiu Quan-Sheng*, Arabidopsis NHX5 and NHX6 regulate PIN6-mediated auxin homeostasis and growth, Journal of Plant Physiology, 2020, 255:153305.

(9) Zhu Xiaojie#, Pan Ting#, Zhang Xiao, Fan Ligang, J. Quintero Francisco, Zhao Hong, Su Xiaomeng, Li Xiaojiao, Villalta Irene, Mendoza Imelda, Shen Jinbo, Jiang Liwen, M. Pardo Jose, Qiu Quan-Sheng*, K+ Efflux Antiporters 4, 5, and 6 Mediate pH and K+ Homeostasis in Endomembrane Compartments, Plant Physiology, 2018, 178(4): 1657-1678. 

(10) Zheng Sheng, Pang Ting, Fan Ligang, Qiu Quan-Sheng*, A novel AtKEA gene family, homolog of bacterial K⁺/H⁺ antiporters, plays potential roles in K⁺ homeostasis and osmotic adjustment in Arabidopsis, PLoS One, 2013, 8(11).