研究领域

病原微生物致病性及耐药性机制研究、益生菌功能等

面向所有志在科研的青年俊才，诚聘病原微生物和肠道微生物及相关方向博士后！

已发表论文：

1. Gukui Chen^#, Jianhua Gan^#, Chun Yang, Yili Zuo, et al. The SiaA/B/C/D signaling network regulates biofilm formation in Pseudomonas aeruginosa. The EMBO Journal, 2020 Mar 16;39(6):e103412. DOI: 10.15252/embj.2019103412. PMID: 32090355.

2. Gukui Chen#, Jiashen Zhou#, Yili Zuo, Weiping Huo, et al. Structural basis for diguanylate cyclase activation by its bind partner in Pseudomonas aeruginosa. eLife, 2021 Sep 9;10：e67289. DOI: 10.7554/eLife.67289. PMID: 34498587.

3. Gukui Chen, Qiang Zhao, Zhu F, Ronghao Chen, et al. Oligoribonuclease is required for the type III secretion system and pathogenesis of Pseudomonas aeruginosa. Microbiological research, Jul-Aug 2016; 188-189: 90-96. DOI: 10.1016/j.micres.2016.05.002. PMID: 27296966.

4. Juan Peng#, Gukui Chen#, Xuejie Xu, Tietao Wang, et al. Iron facilitates the RetS-Gac-Rsm cascade to inversely regulate protease IV (piv) expression via the sigma factor PvdS in Pseudomonas aeruginosa. Environmental Microbiology, 2020 Dec; 22(12)：5402-5413. DOI: 10.1111/1462-2920.15270. PMID: 33015962.

5. Yaqin Song#, Chun Yang#, Gukui Chen#, Yixi Zhang, et al. Molecular insights into the master regulator CysB-mediated bacterial virulence in Pseudomonas aeruginosa. Molecular Microbiology, 2019 May; 111(5): 1195-1210. DOI: 10.1111/mmi.14200. PMID: 30618115.

6. Yuying Han, Tietao Wang, Gukui Chen, Qingqing Pu, et al. A Pseudomoans aeruginosa type 6 secretion system regulated by CueR facilitates copper acquisition. Plos Pathogens (2019) 15(12): e1008198。

7. Xia B, Li M, Tian Z. Chen G, et al. Oligoribonuclease contributes to tolerance to aminoglycoside and beta-lactam antibiotics by regulating KatA in Pseudomonas aeruginosa. Antimicrob Agents and Chemother (2019), 63(6), e00212-19.

8. Yani Zhang, Chao Zhang , Xiao Du, Yun Zhou, Weina Kong, Gee W. Lau, Gukui Chen, et al. Glutathione activates type 3 secretion system through Vfr in Pseudomonas aeruginosa. Frontiers in Cellular and Infection Microbiology (2019), 16: 164.

9. Huiqin Liu, Weina Kong, Weina Yang, Gukui Chen, et al. Multilocus sequence typing and variations in the oprD gene of Pseudomonas aeruginosa isolated from a hospital in China. Infection and Drug Resistance 2018:11 45-54.

10. Chen F, Chen G, Liu Y, Jin Y, et al. Pseudomonas aeruginosa oligoribonuclease contributes to tolerance to ciprofloxacin by regulating pyocin biosynthesis. Antimicrobial Agents and Chemotherapy (2017), 61(3) e02256-16.

11. Yani Zhang, Jing Qin, Boren Tan, Weina Kong, Gukui Chen, et al. The P-type ATPase PA1429 regulates quorum sensing systems and bacterial virulence. Frontiers in Microbiology (2017), 8: 2449.

12. Li K, Xu C, Jin Y, Sun Z, Liu C, Shi J, Chen G, Chen R, et al. SuhB is a regulator of multiple virulence genes and essential for pathogenesis of Pseudomonas aeruginosa. Mbio (2013), 4(6): e00419-13.

获批基金：

1. 国家自然科学基金面上项目，在研。

2. 国家自然科学基金青年科学基金项目，结题，主持。

3. 陕西省自然科学基础研究计划一般项目（青年），结题，主持。