简介:

中文主页 -个人简介

陈卓玥,女,汉族,1987年8月生,陕西兴平人,中共党员,现为西北大学生命科学学院副教授。Email: zychen@nwu.edu.cn

主要研究方向:瞄准骨修复、关节软骨及软骨下骨的修复中面临的关键前沿科学问题,持续开展系列攻关研究。(一)研发了BMP2修饰的3D打印PLA材料,可诱导骨组织异位再生;(二)重组HLC-BMP2融合蛋白,显著降低了骨诱导过程中的过度骨增生,对可控诱导骨形成材料的研发具有重要意义。(三)研发了重组类弹性蛋白修饰的丝素蛋白纤维支架(S-ELP-DHT),对软骨及软骨下骨的关节缺损修复治疗具有重要意义。

现主持国家自然基金面上项目一项,主持的国家自然科学基金青年项目、中国博士后科学基金、陕西省教育厅专项科研计划项目已结题。

指导学生获得全国大学生生命科学创新创业大赛一、三等奖各一次,指导学生参加iGEM全球大赛,国家级大学生创新创业训练等;以第一作者(或通讯作者)发表SCI收录论文12篇,成果他引400余次,已授权发明专利4项。


教育工作经历:

2023.02- 今 ,西北大学生命科学与医学部 副教授

2019.06-2023.01 ,西北大学生命科学与医学部 讲师

2019.11-2022.01,耶鲁大学病理学系  访问学者

2017.01-2019.06 西北大学生命科学与医学部 师资博士后

2012.09-2016.12  西北大学生命科学学院 细胞生物学 博士

2009.09-2012.06  西南交通大学  生物医学工程 硕士推免

2005.09-2009.06  重庆大学  生物工程 本科


主持科研项目:

(1)国家自然科学基金面上项目(新型RADA16-类人胶原融合材料的制备及其快速止血和促进组织修复性能的研究,2022.1-2025.1232171329,58万)

(2)国家自然科学基金青年项目(重组类人胶原-骨形成蛋白融合材料的制备及其诱导成骨作用的研究,2018.1-2020.12,21706212,26万)

(3)中国博士后科学基金面上项目(基因重组类人胶原蛋白作为骨形成蛋白缓释载体的研究,2018.1-2019.6,2017M623228,5万)

(4)陕西省教育厅自然科学专项课题(新型类弹性蛋白-蚕丝纤维复合材料制备的研究2016.7-2018.12,16JK2245,2万)


第一或通讯作者文章

(1)Yayuan Guo, Zeyu Hu, Jilong Chen,Zhen Zhang, Qian Liu, Juan Li, Jiaojiao Yang, Zihan Ma, Jing Zhao, Jingyan Hu, Jiawei Wu, Zhuoyue Chen. Injectable TG-linked recombinant human collagen hydrogel loaded with bFGF for rat cranial defect repair. Int J Biol Macromol., 2023, 236(2023):123864 (通讯作者,一区,IF=8.025).

(2)Yayuan Guo, Nanqiong Cheng, Hongxiao Sun, Jianing Hou, Yuchen Zhang, Du Wang, Wei Zhang, Zhuoyue Chen. Advances in the development and optimization strategies of the hemostatic biomaterials. Front Bioeng Biotechnol., 2022; 10: 1062676. (通讯作者,二区,IF=6.064).

(3)Zhuoyue Chen; Zhen Zhang; Zhaoyue Wang; Jiawei Wu; Yihang Wang; He Si; Xin Xie; Lijun Shang*; Daidi Fan*; Fulin Chen*; Fabricating a novel HLC-hBMP2 fusion protein for the treatment of bone defects, Journal of Controlled Release, 2021, 329: 270-285 (一作,一区,IF=9.776).

(4)Zhuoyue Chen; Qiang Zhang; Hongmin Li; Qi Wei; Xin Zhao*; Fulin Chen*, Elastin-like polypeptide modified silk fibroin porous scaffold promotes osteochondral repair, Bioactive Materials, 2021, 16(3): 589-601 (一作,一区,IF=14.593,他引24).

(5)Yayuan Guo, Zhengyue Bian, Qian Xu, Xiaomin Wen, Juan Kang, Shuai Lin, Xue Wang, Zhaoxiang Mi, Jihong Cui, Zhen Zhang, Zhuoyue Chen *, Fulin Chen*. Novel tissue-engineered skin equivalent from recombinant human collagen hydrogel and fibroblasts facilitated full-thickness skin defect repair in a mouse model. Mater Sci Eng C Mater Biol Appl. 2021, 130:112469 (共同通讯,一区,IF=7.328).

(6)Zhuoyue Chen; Daidi Fan*; Lijun Shang*; Exploring the potential of the recombinant human collagens for biomedical and clinical applications: a short review, Biomedical Material, 2020, 16: 012001(一作,二区,IF=3.715).

(7Zhuoyue Chen; Zhen Zhang; Xiaoxuan Ma; Zhiguang Duan; Junfeng Hui; Chenhui Zhu; Donggang Zhang; Daidi Fan*; Lijun Shang*; Fulin Chen*; Newly Designed Human-Like Collagen to Maximize Sensitive Release of BMP-2 for Remarkable Repairing of Bone Defects, Biomolecules, 2019, 9: 450 (一作,二区,IF=4.082,他引14).

(8) Rongrong Wang, Zhaoyue Wang, Yayuan Guo, Hongmin Li, Zhuoyue Chen*, Design of a RADA16-based self-assembling peptide nanofiber scaffold for biomedical applications, Journal of biomaterials science-polymer edition, 2019, 30(9): 713-736 (通讯作者,二区,IF=2.69,他引19).

(9Zhuoyue Chen, Zhen Zhang, Juantao Feng, Yayuan Guo, Yuan Yu, Jihong Cui, Hongmin Li, Lijun Shang*, The influence of Mussel-Derived Bioactive BMP-2 decorated PLA on MSCs behavior in vitro and verification with osteogenicity at ectopic sites in vivo, ACS Appl Mater Inter, 2018, 10: 11961-71 (一作,一区,IF=8.456,他引16)

(10Zhuoyue Chen#, Yue Song#, Jing Zhang, Wei Liu, Jihong Cui*, Hongmin Li, Fulin Chen, Laminated electrospun nHA/PHB-composite scaffolds mimicking bone extracellular matrix for bone tissue engineering, Materials Science & Engineering C Materials for Biological Applications, 2017, 72(1):341-351 (共一,一区,IF=5.08,他引45)

(11Zhuoyue Chen#, Jing Wei#, Jun Zhu, Wei Liu, Jihong Cui, Hongmin Li, Fulin Chen*, Chm-1 gene-modified bone marrow mesenchymal stem cells maintain the chondrogenic phenotype of tissue-engineered cartilage, Stem Cell Research & Therapy, 2016, 7(1): 70 (共一,一区,IF=4.211,他引10)

(12Zhuoyue Chen*, Quanli Li, Jialong Chen, Rifang Luo, Manfred F. Maitz, Nan Huang*, Immobilization of serum albumin and peptide aptamer for EPC on polydopamine coated titanium surface for enhanced in-situ self-endothelialization, Materials Science & Engineering C Materials for Biological Applications, 2016, 60(1): 219-229 (一作通讯,二区,IF=4.164,他引20)

 

非第一或通讯作者文章

(1) Yayuan Guo, Bing Xu, Yihang Wang, Yan Li, He Si, Xiaoyan Zheng, Zhuoyue Chen, Fulin Chen*, Daidi Fan*. Dramatic promotion of wound healing using a recombinant human-like collagen and bFGF cross-linked hydrogel by transglutaminase. J Biomater Sci Polym Ed. 2019, 30(17):1591-160 (七作,二区,IF=2.69)

(2) Jialong Chen, Juan Wang, Pengkai Qi, Xin Li, Baolong Ma, Zhuoyue Chen, Quanli Li, Yuancong Zhao, Kaiqin Xiong, Manfred F. Maitz, Nan Huang*, Biocompatibilitystudies of poly(ethylene glycol)-modified titanium for cardiovascular devices, Journal of Bioactive and Compatible Polymers, 2012, 27(6): 565-584 (六作,二区,IF=2.207)

(3) Jialong Chen, Cheng Chen, Zhuoyue Chen, Junying Chen, Quanli Li*, Nan Huang*, Collagen/heparin coating on titanium surface improves the biocompatibility of titanium applied as a blood-contacting biomaterial, J Biomed Mater Res A, 2010, 95(2): 341-349 (三作,二区,IF=3.044,他引52).

注:他引超过10次以上作了标注,统计时间为2022年6月。


发明专利:

(1)黄楠,陈卓玥,陈佳龙,李全利,王进,冷永祥,杨苹,陈俊英,孙鸿,吴熹,一种心血管植入装置表面固定多肽适配子的方法,2011.6.8,中国,CN201010589076.4

(2)黄楠,陈佳龙,王娟,李全利,曹建军,陈卓玥,熊开琴,孙鸿,杨苹,冷永祥,陈俊英,王进,一种用于冠心病检测和治疗的纳米磁性粒子的制备方法,2011.6.8,中国,CN201110000852.7

(3)陈富林,陈卓玥,李红民,谢鑫,崔继红,余源,张婧,一种类弹性蛋白蚕丝纤维多孔复合材料及其应用,2019.6.4,中国,ZL 201710024586.9

(4)陈卓玥,陈富林,侯增淼,梁强,赵金礼,一种RHC-(RADA)4融合蛋白,2022.11.1,中国,ZL 201910375539.8