李 想，博士，教授，博士生导师。陕西省高层次人才特聘专家；陕西省抗癌协会MDS专业委员会副主任委员；中国抗癌协会肿瘤营养专业委员会代谢学组委员；陕西省高校教执委医学专业委员会委员；陕西省生化与分子生物学理事；主持国家自然科学基金6项，省部级科学基金7项；在Blood、Leukemia、Redox Biology、Haematologica等学术期刊上发表论文40余篇。目前的研究方向是骨髓微环境对造血干细胞的命运决定以及肿瘤细胞的微环境。

 

工作经历：

2017年-至今     西北大学生命科学与医学部 教授 博士生导师

2013年-2016年  江南大学医学院   副教授 硕士生导师

2007年-2013年  美国Fred-Hutchinson 癌症研究中心（西雅图），博士后

 

主持国家/省级级科研项目： 

1. 骨髓微环境内间充质干细胞的O-GlcNAc修饰影响造血稳态的研究 国家自然科学基金 重大研究计划（培育项目）92478123 2025.01-2027.12

2. MDS克隆细胞中TWIST1影响BMMSC成脂/成骨分化重编程的机制研究 国家自然科学基金面上项目 82370147 2024.01-2027.12

3. 基质细胞中平分型GlcNAc调控黏附因子MCAM表达并重塑MDS骨髓微环境的机制研究 国家自然科学基金面上项目 32071274 2021.01-2024.12

4. 骨髓基质细胞中β4GALT1介导高危MDS克隆细胞增殖和耐药的机制研究  国家自然科学基金面上项目  81770123 2018-2021

5. 转录因子TWIST1 参与骨髓增生异常综合征（MDS）中DNA甲基化作用机制的研究 国家自然科学基金面上项目 81470294  2015-2018

6.由N-乙酰氨基葡萄糖转移酶-III（MGAT3）催化的平分型N-糖链在骨髓造血微环境中的功能研究 国家自然科学基金青年项目31400691  2015-2017

7.基质细胞平分型N糖链影响MCAM表达并介导MDS细胞增殖机制 陕西省自然科学基金面上项目 2018JM3014  2018-2019

8.β1,4-半乳糖转移酶1（β4GALT1）在骨髓造血微环境中的功能研究 江苏省自然科学基金青年项目 BK20140169 2014-2017

9. 血液肿瘤共培养细胞模型的组学分析 教育部留学归国人员基金  2014-2016

 

部分代表论文：(*为通讯作者文章)

1.  Yihan Ma, Chongfu Zhao, Jingjing Feng, Junjie Gou, Enci Kang, Feng Guan, Qiong Wu, Xiang Li*. MSC-sEVs exacerbate senescence by transferring bisecting GlcNAcylated GPNMB. Stem Cell Res Ther. 2025 Jan 23;16(1):23.

2. Junjie Gou ^#, Jingjing Bi ^#, Kexin Wang, Lei Lei, Yanli Feng, Zengqi Tan, Jiaojiao Gao, Yanan Song, Enci Kang, Feng Guan, Xiang Li*. O-GlcNAcylated FTO promotes m6A modification of SOX4 to enhance MDS/AML cell proliferation. Cell Commun Signal. 2025 Jan 23;23(1):43.

3.   Hongjiao Li, Yi Wang, Fengang Yang, Shuang Feng, Kaijing Chang, Feng Guan, Xiang Li*. Clonal MDS/AML cells with enhanced TWIST1 expression reprogram the differentiation of bone marrow MSCs. Redox Biol. 2023 Sep 21; 67:102900. doi: 10.1016/j.redox.2023.102900.

4. Hongjiao Li, Yi Wang, Shuang Feng, Kaijing Chang, Xinwen Yu, Haozhe Huang, Yi Wang, Xiang Li, Feng Guan. Reciprocal regulation of TWIST1 and OGT determines the decitabine efficacy in MDS/AML. Cell Commun Signal. 2023 Sep 22;21(1):255.  

5.  Lei Lei, Yi Wang, Rui Liu, Jingjing Feng, Juan Tang, Junjie Gou, Feng Guan*, Xiang Li *. Transfer of miR-4755-5p through extracellular vesicles and particles induces decitabine resistance in recipient cells by targeting CDKN2B. Mol Carcinog. 2023 Jun;62(6):743-753.

6. Hongjiao Li, Xiaoyue Ren, Xingchen Pang, Pengyu Yang, Yurong Lu, Feng Guan, Yi Wang*, Xiang Li *. LacNAc modification in bone marrow stromal cells enhances resistance of myelodysplastic syndrome cells to chemotherapeutic drugs. Biochim Biophys Acta Mol Cell Res. 2023 May 17;1870(6):119492.

7.  Hongjiao Li, Fenfang Yang, Kaijing Chang, Xinwen Yu, Feng Guan*, Xiang Li *. The synergistic function of long and short forms of β4GalT1 in p53-mediated drug resistance in bladder cancer cells. Biochim Biophys Acta Mol Cell Res. 2023 Feb;1870(2):119409.

8. Jingjing Feng, Yi Wang, Bingxin Li, Xinwen Yu, Lei Lei, Jinpeng Wu, Xin Zhang, Qiushi Chen, Yue Zhou, Junjie Gou, Hongjiao Li, Zengqi Tan, Zhijun Dai, Xiang Li*, Feng Guan*. Loss of bisecting GlcNAcylation on MCAM of bone marrow stoma determined pro-tumoral niche in MDS/AML. Leukemia. 2023 Jan;37(1):113-121.

9.   Zengqi Tan,Yazhuo Jiang, Liang Liang, Jinpeng Wu, Lin Cao, Xiaoman Zhou, Zhihui Song, Zhenyu Ye, Ziyan Zhao, Hui Feng, Zewen Dong, Shuai Lin, Zhangjiang Zhou, Yili Wang, Xiang Li*, Feng Guan*. Dysregulation and prometastatic function of glycosyltransferase C1GALT1 modulated by cHP1BP3/ miR-1-3p axis in bladder cancer. J Exp Clin Cancer Res. 2022 Jul 21;41(1):228.

10.   Hongjiao Li, Chenglian Xie, Yurong Lu, Kaijing Chang, Feng Guan*, Xiang Li *. Exosomal miR92a Promotes Cytarabine Resistance in Myelodysplastic Syndromes by Activating Wnt/β-catenin Signal Pathway. Biomolecules. 2022 Oct 9;12(10):1448.

11.  Junjie Gou, Hongjiao Li, Jingjing Bi, Xingchen Pang, Xiang Li*, Yi Wang*. Transfer of IGF2BP3 Through Ara-C-Induced Apoptotic Bodies Promotes Survival of Recipient Cells. Front Oncol. 2022 May 9; 12:801226. 

12. Yutong Fu, Lulu Ning, Jingjing Feng, Xinwen Yu, Feng Guan*, Xiang Li *. Dynamic regulation of O-GlcNAcylation and phosphorylation on STAT3 under hypoxia-induced EMT. Cell Signal. 2022 May; 93:110277. 

13.  Jinpeng Wu, Zengqi Tan, Yazhuo Jiang, Qilong Ma, Junjie Gou, Lulu Ning, Xiang Li*, Feng Guan*. Melatonin reduces proliferation and promotes apoptosis of bladder cancer cells by suppressing O-GlcNAcylation of cyclin-dependent-like kinase 5. J Pineal Res. 2021 Oct;71(3):e12765.

14.   Zengqi Tan, Lin Cao, Yurong Wu, Bowen Wang, Zhihui Song, Juhong Yang, Lanming Cheng, Xiaomin Yang, Xiaoman Zhou, Zhijun Dai, Xiang Li*, Feng Guan*. Bisecting GlcNAc modification diminishes the pro-metastatic functions of small extracellular vesicles from breast cancer cells. Journal of extracellular vesicles. 2020 Sep; 10:56-72. 

15.  Hongjiao Li, Yi Wang, Xinchen Pang, Chenglian Xie, H. Joachim Deeg, Hui Wang, Ting Wan, Jinpeng Wu, Feng Guan and Xiang Li*. Elevated TWIST1 expression in myelodysolastic syndromes/acute myeloid leukemia reduces efficacy of hypomethylationg therapy with decitabine. Heamatologica. 2020;105: e506

16.  Rui Liu,Yi Wang, Feng Guan, Zengqi Tan, Xiang Li*. Screening differentially expressed proteins from co-cultured hematopoietic cells and bone marrow-derived stromal cells by quantitative proteomics (SILAC) method. Clin Proteomics. 2019 Jul 18; 16:32.

17. Xingchen Pang, Hongjiao Li, Feng Guan, Xiang Li*. Multiple Roles of Glycans in Hematological Malignancies. Front Oncol. 2018 Sep 6; 8:364.

18. Xiang Li, Ting Wan, Sijie Zhang, Dongliang Li, Xiaofeng Han. Quantitative proteomic analysis and comparison of two bone marrow stromal cell lines using the SILAC method. Exp Hematol. 2016;44(11):1059-1071.

19.  Xiang Li, Dongliang Li, Xingchen Pang, Joachim Deeg, Feng Guan. Quantitative analysis of glycans, related genes, and proteins in two human bone marrow stromal cell lines using an integrated strategy. Exp Hematol. 2015, 43(9):760-769.

20.  Xiang Li, Joachim Deeg. Murine xenogeneic models of myedysplastic syndrome (MDS): An essential role for stroma cell. Exp Hematol. 2014; 42 (1): 4-10.

21. Xiang Li#, Feng Xu#, Karoopongse Ekapun, Mario Marcondes, Kayoung Lee, Joachim Deeg. Allogeneic transplantation, fas signaling, and dysregulation of hepcidin. Biol Blood Marrow Transplant. 2013 Aug; 19(8):1210-9. (Co-first author)

22. Xiang Li, Mario Marcondes , Tobias Ragoczy , Joachim Deeg . Effect of intravenous coadministration of human stroma cell lines on engraftment of long-term repopulating clonal myelodysplastic syndrome cells in immunodeficient mice. Blood Cancer J. 2013 Apr 26;3:e113.

23.Xiang Li, Feng Xu, John Byon, Thalia Papayannopoulou, H.Joachim Deeg, A. Mario Marcondes. Transcriptional regulation of miR-10a/b by TWIST-1 in myelodysplastic syndromes. Haematologica. 2013 Mar; 98(3):414-9.

24. Xiang Li, Mario Marcondes, Ted Gooley, Joachim Deeg. The helix-loop-helix transcription factor TWIST is dysregulated in Myelodysplastic Syndromes. Blood. 2010 Sep 30; 116(13): 2304-14.

25.  Mario Marcondes, Xiang Li, LauraTabellini, Matthias Bartenstain, Joachim Deeg. Inhibition of IL-32 activation by α1 anti-trypsin (AAT-1) is associated with suppression of alloreactivity and increased survival in a murine minor antigen disparate transplant model. Blood. 2011 Nov 3; 118 (18): 5031-9.

26. Mario Marcondes, Xiang Li, Ted Gooley, Joachim Deeg. Identification of DJ-1/Park-7 as a determinant of stroma-dependent and TNF{alpha}-induced apoptosis in MDS by using mass spectrometry and phosphopetide analysis. Blood. 2010 Mar 11; 115(10):1993-2002.