Professor
Supervisor of Doctorate Candidates
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Impact Factor10.676
DOI number:10.1016/j.cell.2016.05.069.
Abstract:To provide a detailed analysis of the molecular components and underlying mechanisms associated with ovarian cancer, we performed a comprehensive mass-spectrometry-based proteomic characterization of 174 ovarian tumors previously analyzed by The Cancer Genome Atlas (TCGA), of which 169 were high-grade serous carcinomas (HGSCs). Integrating our proteomic measurements with the genomic data yielded a number of insights into disease, such as how different copy-number alternations influence the proteome, the proteins associated with chromosomal instability, the sets of signaling pathways that diverse genome rearrangements converge on, and the ones most associated with short overall survival. Specific protein acetylations associated with homologous recombination deficiency suggest a potential means for stratifying patients for therapy. In addition to providing a valuable resource, these findings provide a view of how the somatic genome drives the cancer proteome and associations between protein and post-translational modification levels and clinical outcomes in HGSC. VIDEO ABSTRACT.
Indexed by:Journal paper
Discipline:Natural Science
First-Level Discipline:Biology
Document Type:J
Translation or Not:no
Date of Publication:2016-01-28
Included Journals:SCI
Pre One:27. Shisheng Sun, Punit Shah, Shadi Toghi Eshghi, Weiming Yang, Namita Trikannad, Shuang Yang, Lijun Chen, Paul Aiyetan, Naseruddin Höti, Zhen Zhang, Daniel W. Chan, Hui Zhang*. Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nature Biotechnology. 2016, 34: 84-88.
Next One:25. Shadi Toghi Eshghi, Weiming Yang, Yingwei Hu, Punit Shah, Shisheng Sun, Xingde Li, Hui Zhang*. Classification of tandem mass spectra for identification of N-and O-linked glycopeptides. Scientific Reports. 2016, 6(1): 1-8.
