ATP-triggered, allosteric self-assmbly of DNA nanostructures
Release time:2022-03-28
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Affiliation of Author(s):西北大学
Journal:Journal of the American Chemical Society
Place of Publication:美国
Abstract:Responsive self-assembly is a general process in biological systems and is highly desired in engineered systems.
DNA nanostructures provide a versatile molecular platform for studying such responsive self-assembly. Various triggers have
been explored for DNA nanostructures. However, each trigger requires a unique mechanism for its response. This situation
brings a great challenge to engineer the responsiveness. Herein, we propose an aptamer-based, allosteric mechanism for
responsive DNA self-assembly. The aptamer−ligand binding causes the DNA motif to change its conformation and thus
influences the motif assembly. With a model of an ATP aptamer, we have demonstrated the responsive assembly. Such
responsive behavior, we believe, will be an important element for molecular machines, bioimaging/biosensing, and drug
delivery.
Indexed by:Journal paper
Discipline:Natural Science
Document Type:J
Volume:142
Page Number:665-668
Translation or Not:no
Date of Publication:2019-12-26
Included Journals:SCI
First Author:Qian Li