沈立新，教授,博士生导师。陕西省微生物学会理事，中国微生物学会微生物与免疫学会委员，中国医药生物技术安全委员会委员。主要研究方向：病原微生物分子致病、耐药机制及其新型药物研究；环境微生物应用及分子机制研究，微生物在医用材料、农药方面的应用研究。主持国家自然科学基金、陕西省自然科学基金多项，发表文章60多篇。

近三年代表性文章：

1. Songzhe Fu*, Yixiang Zhang, Rui Wang, Zhiqiang Deng, Fenglan He, Xiaotong Jiang, Lixin Shen*. Longitudinal wastewater surveillance of four key pathogens during an unprecedented large-scale COVID-19 outbreak in China facilitated a novel strategy for addressing public health priorities–A proof of concept study.Water Research.2023.Oct.17. doi: 10.1016/j.watres.2023.120751.

2. Songzhe Fu*, Yixiang Zhang , Rui Wang , Zhiguang Qiu , Weizhi Song , Qian Yang , Lixin Shen*. A novel culture-enriched metagenomic sequencing strategy effectively guarantee the microbial safety of drinking water by uncovering the low abundance pathogens. Journal of Environmental Management.2023 Jul.31. doi:10.1016/j.jenvman.2023.118737.

3. Na Li, Wan Liu, Xiaoyan Zheng*, Qing Wang, Lixin Shen*, Junfeng Hui, Daidi Fan*. Antimicrobial Hydrogel with Multiple pH-ResponsivenessforInfected Burn Wound Healing. Nano Research. 2023 Jun. 22; 11139−11148. doi:10.1007/s12274-023-5751-6. 

4. Qingqing Sun, Lixin Shen*, Bai-Ling Zhang, Jiaoyang Yu, Fu Wei, Yanmei Sun, Wei Chen, Shiwei Wang. Advance on Engineering of Bacteriophages by Synthetic Biology. Infection and Drug Resistance.2023 May.31;16:1941-1953. doi: 10.2147/IDR.S402962.

5. Songzhe Fu, Rui Wang, Zheng Xu,Huiwen Zhou,Zhiguang Qiu, Lixin Shen, Qian Yang, Metagenomic sequencing combined with flow cytometry facilitated a novel microbial risk assessment framework for bacterial pathogens in municipal wastewater without cultivation. iMeta. 2022 Dec.7. doi:10.1002/imt2.77.

6. Ning Mao, Shuwen Xue, Guangming Zhang, Sizhe Xia, Xiaohui Chen, Wencai You, Yanmei Sun, Lixin Shen*, Shiwei Wang*. Crude oil degradation in oilfield produced water by immobilized microbes and oil recovery improvement after its reinjection. International Biodeterioration & Biodegradation. 2022 Sep 173: 105452.

7. Xiaofeng Han, Mengyue Nan, Xinyu Cai, Boling Qiao, Lin Chen and Lixin Shen*. Sennoside A inhibits quorum sensing system to attenuate its regulated virulence and pathogenicity via targeting LasR in Pseudomonas aeruginosa. Frontiers in Microbiology.2022 Nov 03: 13:1042214. doi: 10.3389/fmicb.2022.1042214. eCollection 2022.

8. Yongheng Yang, Mengyun Li, Yongtao Ma, Wei Ye, Yue Si, Xuyang Zheng, He Liu, Linfeng Cheng, Liang Zhang, Hui Zhang, Xijing Zhang, Yingfeng Lei, Lixin Shen*, Fanglin Zhang*，Hongwei Ma*. LncRNA NEAT1 Potentiates SREBP2 Activity to Promote Inflammatory Macrophage Activation and Limit Hantaan Virus Propagation. Frontiers in Microbiology. 2022 Apr 13; 13:849020. doi: 0.3389/fmicb. 2022. 849020.  eCollection.

9.  Jiali Yang, Mengyuan Li, Mingcheng Yuan, Peiyu Bian, Yangchao Dong, Haijun Zhang, Huanyu Luo, Zhifeng Xue, Yuan Wang, Fanglin Zhang, Lixin Shen*, Yingfeng Lei*. Axl∗ /÷ neurons promote JEV infection by dampening the innate immunity. Virus Res.2022 Jan 2; 307:198605. doi: 0.1016/j.virusres.2021.198605. 

10. Shiwei Wang, Yuqi Feng, Xiaofeng Han, Xinyu Cai, Liu Yang, Chaolan Liu and Lixin Shen. Inhibition of Virulence Factors and Biofifilm Formation by Wogonin Attenuates Pathogenicity of Pseudomonas aeruginosa PAO1 via Targeting pqs Quorum-Sensing System. Int. J. Mol. Sci. 2021, 22, 12699. doi.org/10.3390/ijms222312699.

11. Lixin Shen, Lang Gao, Mengjiao Yang, Jian Zhang, Yulu Wang, Yuqi Feng, Liping Wang，Shiwei Wang. Deletion of the PA4427-PA4431 Operon of Pseudomonas aeruginosa PAO1 Increased Antibiotics Resistance and Reduced Virulence and Pathogenicity by Affecting Quorum Sensing and Iron Uptake. Microorganisms. 2021 May 14;9(5):1065. doi: 10.3390/microorganisms9051065.

12. Huanhuan Ning, Wei Zhang, Jian Kang, Tianbing Ding, Xuan Liang, Yanzhi Lu, Chengxuan Guo, Wenjie Sun, Huapeng Wang, Yinlan Bai, Lixin Shen*. Subunit vaccine ESAT-6:c-di-AMP delivered by intranasal route elicits immune responses and protects against Mycobacterium tuberculosis infection. Front Cell Infect Microbiol. 2021 Mar 22; 11:647220. doi: 10.3389/fcimb.2021.647220.

13. Pansong Zhang，Qiao Guo，Zhihua Wei，Qin Yang，Zisheng Guo，Lixin Shen，Kangmin Duan，Lin Chen. Baicalin Represses Type Three Secretion System of Pseudomonas aeruginosa through PQS System. Molecules. 2021, 26(6), 1497. doi:10.3390/molecules26061497.

14. Shiwei Wang, Qiuqiu Hou, Qianqian Guo, Jian Zhang, Yanmei Sun, Hong Wei, Lixin Shen*. Isolation and Characterization of a Deoxynivalenol-Degrading Bacterium Bacillus licheniformis YB9 with the Capability of Modulating Intestinal Microbial Flora of Mice. Toxins (Basel). 2020 Mar; 12(3): 184-197. doi: 10.3390/toxins12030184.

团队名称：分子微生物研究室

团队介绍：病原微生物及药物筛选，环境微生物研究，微生物生物技术