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Professor
Supervisor of Master's Candidates
Biochemical studies on glyoxalase system have implicated Glyoxalase-II (GLX-II) is in detoxification of cytotoxic 2-oxoaldehydes from the cell and the inhibitors of GLX-II can stop growth of tumors, because the tumors have no way to remove the toxic byproducts. In an effort to probe inhibition of GLX-II, we design, synthesize and evaluate glutathione derivatives as inhibitors, and investigated which substitutes on the inhibitor are essential for tight binding, and whether hydrophobic interactions contribute to the tight binding of the inhibitors. This study is targeted for development of potential antitumor reagents.
