郑阿迪，女，西北大学医学院讲师。本科和博士毕业于西安交通大学，2015年获理学博士学位。先后在瑞典卡洛琳斯卡医学院以及瑞士洛桑大学从事博士后工作。2022年进入西北大学医学院。

主要研究方向包括：

1) 线粒体和氧化损伤在肥胖、糖尿病等代谢相关疾病中的作用，并筛选有效的天然化合物及其衍生物，用于预防和治疗相关疾病。

2) 肿瘤迁移与耐药性机制研究。

3) 高密度脂蛋白（HDLs）的保护作用机制研究。

曾参与瑞士国家自然科学基金以及中国自然科学基金的相关课题。迄今为止，发表SCI论文17篇，其中以第一作者在J Nutr Biochem、Cells、J Cell Sci、Curr Opin Lipidol等国际期刊发表研究论文8篇，累积被引800余次。

【主要科研成果】

1. Adi Zheng, Gilles Dubuis, Maria Georgieva, Carla Susana Mendes Ferreira, Marc Serulla, Maria del Carmen Conde Rubio, Evgeniya Trofimenko, Thomas Mercier, Laurent Decosterd and Christian Widmann，HDLs extract lipophilic drugs from cells. J Cell Sci. 2022 Mar 1;135(5):jcs258644.

2. Adi Zheng, Hao Li, Zhihui Feng, Jiankang Liu. Integrative Analyses Reveal Tstd1 as a Potential Modulator of HDL Cholesterol and Mitochondrial Function in Mice. Cells. 2021 Nov 1;10(11):2976.

3. Adi Zheng, Christian Widmann. The interplay between serum amyloid A and HDLs. Curr Opin Lipidol. 2020 Oct;31(5):300-301.

4. Adi Zheng*, Nadja Chevalier*, Margot Calderoni*, Gilles Dubuis, Olivier Dormond, Panos G Ziros, Gerasimos P Sykiotis, Christian Widmann. CRISPR/Cas9 Genome-Wide Screening Identifies KEAP1 as a Sorafenib, Lenvatinib, and Regorafenib Sensitivity Gene in Hepatocellular Carcinoma. Oncotarget. 2019 Dec 17;10(66):7058-7070. (* 为共同一作 )

5. Adi Zheng, Gilles Dubuis, Carla Susana Mendes Ferreira, Jannick Pétremand, Güliz Vanli, Christian Widmann The PI3K/Akt Pathway Is Not a Main Driver in HDL-mediated Cell Protection. Cell Signal. 2019 Oct;62:109347.

6. Adi Zheng, Hao Li, Ke Cao, Jie Xu, Xuan Zou, Yuan Li, Cong Chen, Jiankang Liu, Zhihui Feng. Maternal hydroxytyrosol administration improves neurogenesis and cognitive function in prenatal stressed offspring. J Nutr Biochem. 2015 Feb;26(2):190-9. 

7. Adi Zheng, Hao Li, Jie Xu, Ke Cao, Hua Li, Wenjun Pu, Ziqi Yang, Yunhua Peng, Jiangang Long, Jiankang Liu, and Zhihui Feng. Hydroxytyrosol improves mitochondrial function and reduces oxidative stress in the brain of db/db mice: Role of AMPK activation. Brit J Nutr. 2015 Jun 14;113(11):1667-76. 

8. Adi Zheng, Hao Li, Xun Wang, Zhihui Feng, Jie Xu, Ke Cao, Bo Zhou, Jing Wu and Jiankang Liu. Anticancer effect of a curcumin derivative B63: ROS production and mitochondrial dysfunction. Curr Cancer Drug Targets. 2014 Feb;14(2): 156-166. (IF: 3.7)=

9. 郑阿迪, 刘健康, 冯智辉, 产前应激对子代的影响及潜在作用机制. 中国病理生理杂志, 2014 30 (3): 558-562.

10. Amanda Tomie Ouchida*, Merve Kacal*, Adi Zheng*, Gorbatchev Ambroise, Boxi Zhang, Erik Norberg. Helin Vakifahmetoglu-Norberg. USP10 regulates the stability of the EMT-transcription factor Slug/SNAI2. Biochem Biophys Res Commun. 2018 Aug 25; 502(4):429-434.  (* 为共同一作）

11. Xueqiang Wang*, Weiqiang Lv*, Jie Xu*, Adi Zheng, Mengqi Zeng, Ke Cao, Xun Wang, Yuting Cui, Hao Li, Meng Yang, Yongping Shao, Fang Zhang, Xuan Zou, Jiangang Long, Zhihui Feng, Jiankang Liu Hepatic Suppression of Mitochondrial Complex II Assembly Drives Systemic Metabolic Benefits. Adv Sci. 2022 Mar;9(9):e2105587.

12. Xueqiang Wang *, Xing Zhang *, Ke Cao*, Mengqi Zeng*, Xuyang Fu*, Adi Zheng, Feng Zhang, Feng Gao, Xuan Zou, Hao Li, Min Li, Weiqiang Lv, Jie Xu, Jiangang Long, Weijin Zang, Jinghai Chen, Feng Gao, Jian Ding, Jiankang Liu, Zhihui Feng. Cardiac disruption of SDHAF4-mediated mitochondrial complex II assembly promotes dilated cardiomyopathy. Nat Commun. 2022 Jul 8;13(1):3947.

13. Lin Zhao, Hao Li, Yan Wang, Adi Zheng, Liu Cao, Jiankang Liu Autophagy Deficiency Leads to Impaired Antioxidant Defense via p62-FOXO1/3 Axis. Oxid Med Cell Longev. 2019 Dec 17;2019:2526314.

14. Ke Cao, Adi Zheng, Jie Xu, Hao Li, Jing Liu, Yunhua Peng, Jiangang Long, Xuan Zou, Yuan Li, Cong Chen, Jiankang Liu, Zhihui Feng. AMPK activation prevents prenatal stress-induced cognitive impairment: modulation of mitochondrial content and oxidative stress. Free Radic Biol Med. 2014 Oct;75:156-66.