孔伟娜，副教授，硕士生导师 

个人简历：

2013年毕业于西北大学生命科学学院，获得理学博士学位。同年赴加拿大曼尼托巴大学进行博士后研究。2014年进入西北大学生命科学学院工作，现任副教授职位。本课题组主要从事分子微生物学研究。 

研究领域：

病原菌致病机理及耐药机理研究，新抗菌靶点开发，微生物基因工程改造及应用。 

主持科研项目：

国家自然科学基金面上项目，c-di-GMP合成酶PA1851调控铜绿假单胞菌急慢性感染相关表型的分子机制，2024.1-2027.12

国家自然科学基金青年科学基金项目，铜绿假单胞菌中c-di-GMP信号途径的调控机制及其与慢性感染的关系，2016.1-2018.12

陕西省自然科学基础研究计划项目面上项目，铜绿假单胞菌中c-di-GMP代谢酶的特异性调控分子机制研究，2020.1-2021.12

陕西省自然科学基础研究计划项目青年人才项目，铜绿假单胞菌中VI型分泌系统转录调控因子的筛选及功能研究，2016.1-2017.12

陕西省教育厅自然科学专项基金项目，铜绿假单胞菌急慢性感染转换调控基因的筛选及功能研究，2015.1-2016.12

陕西基础研究科学院科研计划项目青年项目，c-di-GMP代谢酶调控铜绿假单胞菌致病性的分子机制，2023.1-2024.12 

发表论文：

1. Weina Kong, Wei Luo, Yaya Wang, Yu Liu, Qianqian Tian, Cheng Zhao, Haihua Liang. Dual GGDEF/EAL-domain protein RmcA controls the type III secretion system of Pseudomonas aeruginosa by interaction with CbrB. ACS Infectious Diseases, 2022, 8(12): 2441-2450.

2. Weina Kong, Qianqian Tian, Qiaoli Yang, Yu Liu, Gongting Wang, Yanjun Cao, Liping Wang, Sizhe Xia, Yanmei Sun, Cheng Zhao, Shiwei Wang. Sodium selenite enhances antibiotics sensitivity of Pseudomonas aeruginosa and deceases its pathogenicity by inducing oxidative stress and inhibiting quorum sensing system. Antioxidants (Basel), 2021, 10(12): 1873.

3. Weina Kong, Cheng Zhao, Xingwang Gao, Liping Wang, Qianqian Tian, Yu Liu, Shuwen Xue, Zhuang Han, Fulin Chen, Shiwei Wang. Characterization and transcriptome analysis of a long-chain n-alkane-degrading strain Acinetobacter pittii SW-1. International Journal of Environmental Research and Public Health, 2021, 18(12): 6365.

4. Weina Kong, Mengmeng Dong, Rong Yan, Qingqing Liang, Huiqun Zhang, Wei Luo, Yani Zhang, Haihua Liang, Kangmin Duan. A unique ATPase, ArtR (PA4595), represses the type III secretion system in Pseudomonas aeruginosa. Frontiers in Microbiology, 2019, 10: 560.

5. Weina Kong, Jingru Zhao, Huaping Kang, Miao Zhu, Tianhong Zhou, Xin Deng, Haihua Liang. ChIP-seq reveals the global regulator AlgR mediating cyclic di-GMP synthesis in Pseudomonas aeruginosa. Nucleic Acids Research, 2015, 43(17): 8268-8282.

6. Weina Kong, Lin Chen, Jieqiong Zhao, Tuo Shen, Michael G. Surette, Lixin Shen, Kangmin Duan. Hybrid sensor kinase PA1611 in Pseudomonas aeruginosa regulates transitions between acute and chronic infection through direct interaction with RetS. Molecular Microbiology, 2013, 88(4): 784-797. 

7. 张译兮, 张亚妮, 马艳玲, 罗威, 肖雅, 孔伟娜. 铜绿假单胞菌中III型分泌系统调控机制及针对性治疗的研究进展. 微生物学通报, 2019, 46(2): 362-373.

8. 孔伟娜, 梁海华, 沈立新, 段康民. 铜绿假单胞菌中III型分泌系统受Rhl和PQS群体感应系统调节. 微生物学报, 2009, 49(9): 1158-1164.

9. Guang Guo, Fang Tian, Yanhong Zhao, Maomao Tang, Weijie Liu, Cong Liu, Shuwen Xue, Weina Kong, Yanmei Sun, Shiwei Wang. Aerobic decolorization and detoxification of Acid Scarlet GR by a newly isolated salt-tolerant yeast strain Galactomyces geotrichum GG. International Biodeterioration & Biodegradation, 2019, 145: 104818.

10. Yani Zhang, Chao Zhang, Xiao Du, Yun Zhou, Weina Kong, Gee W. Lau, Gukui Chen, Gurjeet Singh Kohli, Liang Yang, Tietao Wang, Haihua Liang. Glutathione activates type III secretion system through Vfr in Pseudomonas aeruginosa. Frontiers in Cellular and Infection Microbiology, 2019, 9:164.

11. Huiqin Liu, Weina Kong, Weina Yang, Gukui Chen, Haihua Liang, Yani Zhang. Multilocus sequence typing and variations in the oprD gene of Pseudomonas aeruginosa isolated from a hospital in China. Infection and Drug Resistance, 2018, 11: 45-54.

12. Yani Zhang, Jing Qin, Boren Tan, Weina Kong, Gukui Chen, Chao Zhang, Haihua Liang. The P-type ATPase PA1429 regulates quorum-sensing systems and bacterial virulence. Frontiers in Microbiology, 2017, 8: 2449.

13. Anjali Y. Bhagirath, Sai P. Pydi, Yanqi Li, Chen Lin, Weina Kong, Prashen Chelikani, Kangmin Duan. Characterization of the direct interaction between hybrid sensor kinases PA1611 and RetS that controls biofilm formation and the type III secretion system in Pseudomonas aeruginosa. ACS Infectious Diseases, 2017, 3(2): 162-175.

14. Huaping Kang, Jianhua Gan, Jingru Zhao, Weina Kong, Jing Zhang, Miao Zhu, Fan Li, Yaqin Song, Jin Qin, Haihua Liang. Crystal structure of Pseudomonas aeruginosa RsaL bound to promoter DNA reaffirms its role as a global regulator involved in quorum-sensing. Nucleic Acids Research, 2017, 45(2): 699-710.

15. Miao Zhu, Jingru Zhao, Huaping Kang, Weina Kong, Yuanyu Zhao, Min Wu, Haihua Liang. Modulation of type III secretion system in Pseudomonas aeruginosa: involvement of the PA4857 gene product. Frontiers in Microbiology, 2016, 7: 7.

16. Jing Qi, Bobo Wang, Jing Li, Huanhuan Ning, Yingjuan Wang, Weina Kong, Lixin Shen. Genetic determinants involved in the biodegradation of naphthalene and phenanthrene in Pseudomonas aeruginosa PAO1. Environmental Science and Pollution Research, 2015, 22(9): 6743-6755.

17. Qiao Guo, Weina Kong, Sheng Jin, Lin Chen, Yangyang Xu, Kangmin Duan. PqsR-dependent and PqsR-independent regulation of motility and biofilm formation by PQS in Pseudomonas aeruginosa PAO1. Journal of Basic Microbiology, 2014, 54(7): 633-643.

18. Haihua Liang, Weina Kong, Tuo Shen, Jiali Duan, Kangmin Duan. The effect of pmpR on the type III secretion system in Pseudomonas aeruginosa. Chinese Science Bulletin, 2012, 57(19): 2413-2418.

19. Haihua Liang, Lingling Li, Weina Kong, Lixin Shen, Kangmin Duan. Identification of a novel regulator of the quorum-sensing systems in Pseudomonas aeruginosa. FEMS Microbiology Letters, 2009, 293(2): 196-204.